Inhalatory anesthetic (HALOTHANE) associated changes in the immune response in mice

Elena, G; Puig, N; Bay, María Luisa; UrÍzar, Laura; Barragan, J.; Comba, J. O.; Amerio, N

doi:10.1016/s0192-0561(97)00105-7

Cited by 17 publications

(17 citation statements)

References 22 publications

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“…In contrast, neither anesthetic induced dramatic changes of cell membrane plasticity or hypertrophy of the Golgi apparatus, nor did they produce any profound effect on the platelets. Isoflurane shares the halothane-anesthetic mechanism, but displays very low biotransformation and shows no immune response in the same model (Baden and Rice, 1990;Puig et al, 1995;Elena et al, 1997). It has a reduced tendency to cause perturbation of the cell membrane when compared with halothane (Koubi et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, this study was motivated by the possibility that the PIM is the major resident immune effector cell in the pulmonary microcirculation of the equine lung; as such it would represent the first line of defense of the lung against blood borne pathogens. Inhalatory anesthetics, particularly halothane, may cause acute or chronic toxicity because of the production of intermediate and end metabolic compounds (Elena et al, 1997). Halothane is bioactively converted into trifluoroacetylated polypeptides to induce hepatotoxicity in humans as well as in laboratory animals.…”

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confidence: 99%

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In vivo interaction of pulmonary intravascular macrophages with activated platelets in microvessels of equine lung after multiple exposures to halothane, isoflurane, and thiamylal: A comparative ultrastructural and cytochemical study

Atwal

McDonell

2005

Anat. Rec.

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The pulmonary intravascular macrophages (PIMs) of equines contain a unique electron-dense surface coat that is predominantly composed of lipoproteins. A single exposure of inhalatory halothane causes mobilization of the surface coat into the endocytotic system of the PIMs, followed by expansion of the Golgi apparatus and its enrichment with acid phosphatase. Simultaneously, the cells of the lymphocytic series show hyperplasia in the form of mitotic changes inside the microvascular compartment of the lung. Halothane is known to cause acute and chronic hepatotoxicity because of its biotransformation into trifluoroacytelated polypeptides. The present study was designed to examine the comparative effects of reexposures of inhalatory doses of halothane, isoflurane, and the intravenous barbiturate thiamylal sodium in ponies to evoke a stronger response in the PIMs after four exposures at increasing intervals of 1, 2, and 6 weeks. Ultrastructural and cytochemical evidence is presented that halothane induced translocation of the surface coat into the vacuolar system of the PIMs, followed by expansion of the Golgi apparatus and its enrichment with acid phosphatase. The cell membrane was thrown into extraordinary lamellipodial extensions, which enabled the PIMs to interact with platelets within the narrow confines of the pulmonary capillaries. The relationship between PIMs and platelets developed into large platelet aggregates. Isoflurane and thiamylal sodium did not affect the circulating platelets, although the surface coat was translocated into the endolysosomes in both situations. Although isoflurane is a lipid-soluble inhalant anesthetic similar to halothane, it is subject to very little biotransformation after use and in the present model demonstrates no immune response.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

In vivo interaction of pulmonary intravascular macrophages with activated platelets in microvessels of equine lung after multiple exposures to halothane, isoflurane, and thiamylal: A comparative ultrastructural and cytochemical study

Atwal

McDonell

2005

Anat. Rec.

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“…In the next section, most Propofol ↓ phagocytosis and respiratory burst and ↑ cell counts 13,14,16,18 Isoflurane ↓ phagocytosis and respiratory burst 16,18 Bupivacaine ↓ phagocytosis and chemotaxis 16,18 Lidocaine ↓ phagocytosis and chemotaxis 16,18 Desflurane ↑ cell counts Midazolam ↓ phagocytosis and respiratory burst 15,18 Thiopental ↓ phagocytosis and respiratory burst 15,18 Lidocaine ↓ cell counts Sevoflurane ↓ cell counts 14,21 Halothane ↓ cell counts 14,21 Isoflurane ↑ cell counts 13,25 Desflurane ↑ cell counts 13,25 Isoflurane ↑ apoptosis…”

Section: Effects Of Anaesthetic Drugs On Immune Cellsmentioning

confidence: 99%

“…Isoflurane ↑ cell counts 13,25 Desflurane ↑ cell counts 13,25 Halothanes ↑ antibody titre 14,21 , while isoflurane and desflurane increases CD8 cell numbers 13,25 .…”

Section: Cd19 B Lymphocytesmentioning

confidence: 99%

Untitled

2013

OA Anaesthetics

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IntroductionThe immune system protects us from infections through coordinate action of its components. Patients and animals undergoing anaesthesia and surgery show alterations in the immune response. In this paper, we review the effects of some of the most common anaesthetic drugs on the immune system, in particular the effects within 24 hours after their administration, describing their effects on cells and cytokines of the innate and acquired immune system. Discussion As it is difficult to isolate the effects of anaesthetic drugs in the case of surgery, diverse in vitro studies with human immune cells or in vivo with animal models have been used to study the effect of anaesthetic drugs on the immune system. These studies have demonstrated diverse effects, such as changes in immune cell counts and functionality, and on the secretion patterns of diverse cytokines affecting the inflammatory response in the postoperative period. Conclusion Effects of anaesthetic drugs on the immune system are clinically important because the amount and function of the immune cells, as well as the balance between pro-and anti-inflammatory cytokines secretion, are related to postoperative infections and tissue injury.

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“…Although the controversial data arising whether the immune effect of surgery has depended on anaesthesia or surgical trauma, it is possible to compare the immune interaction of different anesthetic approaches by evaluating similar patient groups and extend of surgery. A recent study investigating the immune-effects of the first inhalation anesthetic, halothane, revealed that CD4, CD8 cells and B-lymphocytes significantly decreased with repeating doses of halothane (8). Le Cras et al suggested that spinal anesthesia causes less immunosupression in transurethral resection patients that inferring type of anesthesia has been important factor on surgery (9).…”

Section: S Su Um MM Ma Ar Ry Ymentioning

confidence: 99%

The Effects of Isoflurane and Sevoflurane on Immune System in Minor Surgical Interventi̇ons

Durlu¹,

Batiislam²,

Özatamer³

2002

Journal of Ankara Medical School

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In the present state of knowledge, anaesthesia and surgery depress immune system by direct effects of anesthetic agents and indirect interaction of hormonal and metabolic changes caused by surgical stress. Every component of immunologic profile can be altered during anaesthesia and sur- - Hematological and most of the immunological measurements were in normal ranges throughout the study and no statistically significant difference was observed between sevoflurane and isoflurane groups. Time related differences observed in each group consisting increases in IgG, B and T lymphocytes and T-helper and decrease in T-suppressor levels with protection of complement levels in isoflurane group. Although the laboratory data showed better immune response for isoflurane, statistical analyses did not support these findings. Even though different aspects of immune system changes have been in the advantage of isoflurane regarding laboratory data, statistical methods did not revealed a meaningful difference in each comparison.K Ke ey y W Wo or rd ds s: Immune Response, Isoflurane, Minor Surgery, Sevoflurane, Ö ÖZ ZE ET T M Mi in nö ör r C Ce er rr ra ah hi i G Gi ir ri iş şi im ml le er rd de e İ İs so of fl lo or ra an n v ve e S Se ev vo of fl lo or ra an nı ın n İ İm mm mü ün n S Si is st te em me e E Et tk ki il le er ri i Anestezi ve cerrahinin immün sisteme olan etkileri uzun süredir bilinmektedir ve immün etkileşim girişimlerin morbiditesini arttırabilmektedir. Prospektif çalışmamızda sık kullanılan inhalasyon anestetikleri sevofloran ve izofloranın minör cerrahi uygulanan hastalarda immunolojik etkilerini karşılaştırmayı planladık. İmmünolojik yetmezliği olmayan ve minör cerrahi girişim uygulanan 44 hasta çalışmaya dahil edildi.Aynı indüksiyon tekniği uygulandıktan sonra 22 hastaya izofloran ve 22 hastaya sevofloran uygulandı.Kan örnekleri preoperatif ve postoperatif 1 ve 3. Günlerde olmak üzere 3 kez alındı. Laboratuvar incelemelerde lökosit sayımı, serum immunglobulinler, kompleman, lenfositler, T-lenfosit ve alt grupları bakıldı. İzofloran ve sevofloran grupları arasında hematolojik ve çoğu immünolojik ölçümler normal sınırlar içindeydi ve istatistiksel fark yoktu.A An na ah ht ta ar r K Ke el li im me el le er r: : İmmün Yanıt, İzofloran, Minor Cerrahi, Sevofloran

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Inhalatory anesthetic (HALOTHANE) associated changes in the immune response in mice

Cited by 17 publications

References 22 publications

In vivo interaction of pulmonary intravascular macrophages with activated platelets in microvessels of equine lung after multiple exposures to halothane, isoflurane, and thiamylal: A comparative ultrastructural and cytochemical study

In vivo interaction of pulmonary intravascular macrophages with activated platelets in microvessels of equine lung after multiple exposures to halothane, isoflurane, and thiamylal: A comparative ultrastructural and cytochemical study

Untitled

The Effects of Isoflurane and Sevoflurane on Immune System in Minor Surgical Interventi̇ons

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