Inhalational anesthesia vs total intravenous anesthesia (TIVA) for pediatric anesthesia

Lerman, Jerrold; Jöhr, Martin

doi:10.1111/j.1460-9592.2009.02962.x

Cited by 95 publications

(68 citation statements)

References 90 publications

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“…Our children were adequately sedated with remifentanil and propofol during the final weaning phase and revealed a Hartwig score of 10.9±2.8 (range [8][9][10][11][12][13][14][15][16]. Remifentanil and propofol were applied for 7±2.8 h (4-12 h) with an average dose remifentanil 39±7.5 μg/kg/h (30-45 μg/kg/h) and propofol 2.8±0.9 mg/kg/h (2-4 mg/kg/h).…”

Section: Resultsmentioning

confidence: 99%

Remifentanil and propofol for weaning of mechanically ventilated pediatric intensive care patients

et al. 2010

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Mechanically ventilated pediatric intensive care patients usually receive an analgesic and sedative to keep them comfortable and safe. However, common drugs like fentanyl and midazolam have a long context sensitive half time, resulting in prolonged sedation and an unpredictable extubation time. Children often awake slowly and struggle against the respirator, although their respiratory drive and their airway reflexes are not yet sufficient for extubation. In this pilot study, we replaced fentanyl and midazolam at the final phase of the weaning process with remifentanil and propofol. Twenty-three children aged 3 months-10 years were enrolled. Remifentanil and propofol revealed throughout excellent or good weaning conditions with rapid transition from hypnosis to the development of regular spontaneous breathing, airway protective reflexes, and an appropriate level of alertness. Extubation time following discontinuation of the remifentanil and propofol infusion was only 24 ± 20 min (5-80 min). We conclude that the combination of remifentanil and propofol is a promising option to improve the weaning conditions of pediatric intensive care patients. Randomized controlled trials are needed to compare remifentanil and propofol with conventional weaning protocols.

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Section: Resultsmentioning

confidence: 99%

Remifentanil and propofol for weaning of mechanically ventilated pediatric intensive care patients

et al. 2010

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“…Maintenance of anesthesia via the intravenous route in neonates is also fraught with pitfalls for several reasons [ 231 ]. First, the IV lines are particularly fragile in neonates.…”

Section: Maintenance Of Anesthesiamentioning

confidence: 99%

Selection of Anesthesia Techniques for the Neonate

Sabourdin

Louvet

Constant

2014

Neonatal Anesthesia

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“…Hepatic and renal immaturity in children and the individual variability observed in intravenous anesthesia can represent limitations for the technique. However, inhalational anesthesia in patients with neuromuscular disorders should not be the technique of choice because the possibility of triggering malignant hyperthermia and rhabdomyolysis cannot be ruled out 24 . Werdnig-Hoffmann disease is considered a relative contraindication for inhalational anesthesia, mainly due to the risk of rhabdomyolysis 25 .…”

Section: Discussionmentioning

confidence: 99%

Anestesia venosa total (AVT) em lactente com doença de Werdnig-Hoffmann: relato de caso

Resende¹,

Silva²,

Nascimento³

et al. 2010

Rev. Bras. Anestesiol.

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Inhalational anesthesia vs total intravenous anesthesia (TIVA) for pediatric anesthesia

Cited by 95 publications

References 90 publications

Remifentanil and propofol for weaning of mechanically ventilated pediatric intensive care patients

Remifentanil and propofol for weaning of mechanically ventilated pediatric intensive care patients

Selection of Anesthesia Techniques for the Neonate

Anestesia venosa total (AVT) em lactente com doença de Werdnig-Hoffmann: relato de caso

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