Inhalation therapy of equine respiratory disorders

Duvivier, D. H.; Votion, Dominique; Roberts, C. A.; Art, Tatiana; Lekeux, Pierre

doi:10.1111/j.2042-3292.1999.tb00933.x

Cited by 9 publications

(6 citation statements)

References 47 publications

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“…The recommended dosing frequency for pMDI administration of salbutamol to horses is 4–6 h (Duvivier et al ., ). This is entirely consistent with a clinical study in humans whereby efficacy levels (mean change in FEV 1 ) dropped by 50% after 4 h from a pMDI therapeutic administration of salbutamol (Van Noord et al ., ).…”

Section: Resultsmentioning

confidence: 97%

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Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration

Wieder¹,

Paine

Hincks³

et al. 2014

Vet Pharm & Therapeutics

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Salbutamol sulphate (Ventolin Evohaler) was administrated via the inhalation route to six horses at a dose of 0.5 mg every 4 h during the day for 2 days (total dose 4 mg). Urine and blood samples were taken up to 92 h postadministration. Hydrolyzed plasma and urine were extracted using solid phase extraction (SPE). A sensitive tandem mass spectrometric method was developed in this study, achieving a lower limit of quantification (LLOQ) for salbutamol of 10 pg/mL in plasma and urine. The parent drug was identified using UPLC-MS/MS. Most of the determined salbutamol plasma concentrations, post last administration, lie below the LLOQ of the method and so cannot be used for plasma PK analysis. Urine PK analysis suggests a half-life consistent with the pharmacological effect duration. An estimate of the urine average concentration at steady-state was collected by averaging the concentration measurements in the dosing period from -12 to 0 h relative to the last administered dose. The value was averaged across the six horses and used to estimate an effective urine concentration as a marker of effective lung concentration. The value estimated was 9.6 ng/mL and from this a number of detection times were calculated using a range of safety factors.

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Section: Resultsmentioning

confidence: 97%

“…clenbuterol which is far more economic) is its efficacy (Cooper et al ., ). The recommended dosage regimen for salbutamol administered via pMDI to horse is 500–1000 mg with a frequency of 4–6 h (Duvivier et al ., ). This is consistent with a study carried out by Bertin et al .…”

Section: Introductionmentioning

confidence: 97%

Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration

Wieder¹,

Paine

Hincks³

et al. 2014

Vet Pharm & Therapeutics

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“…1991). The methyl‐xanthine drug aminophylline is used as a bronchodilator in human beings but has a narrow therapeutic range in horses (Duvivier et al. 1999).…”

Section: Treatmentmentioning

confidence: 99%

Post-anaesthetic pulmonary oedema in horses: a review

Senior

2005

Veterinary Anaesthesia and Analgesia

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“…The use of inhalation therapy in equine practice has recently increased in popularity, particularly in relation to corticosteroid and bronchodilator treatment of equine asthma (Robinson et al ., ; Tesarowski et al ., ; Derksen et al ., , ; Durham, ) but also for the delivery of other therapeutic agents, including antibiotics (Art et al ., ; Burton et al ., ; Ferrucci et al ., ; Fultz et al ., ). The proposed advantages over systemic drug delivery include a relatively lower cost, drug delivery directly to the site of action and, particularly in the case of corticosteroids, a reduced risk of systemic adverse effects (Duvivier et al ., , ; Hoffman, ; Lavoie, ). Various means of aerosol generation exist, including ultrasonic, jet and mesh nebulization and metered dose inhalers (MDIs), each differing with respect to the variability in aerosol particle size distribution (Duvivier et al ., , ; Votion et al ., ).…”

Section: Introductionmentioning

confidence: 99%

“…The proposed advantages over systemic drug delivery include a relatively lower cost, drug delivery directly to the site of action and, particularly in the case of corticosteroids, a reduced risk of systemic adverse effects (Duvivier et al ., , ; Hoffman, ; Lavoie, ). Various means of aerosol generation exist, including ultrasonic, jet and mesh nebulization and metered dose inhalers (MDIs), each differing with respect to the variability in aerosol particle size distribution (Duvivier et al ., , ; Votion et al ., ). Furthermore, a variety of delivery devices are available, including equine‐specific and customized spacers and airtight facemasks, the use of which is indicated largely due to the inability to accurately synchronize aerosol generation with inspiration in the horse (Lavoie, ).…”

Section: Introductionmentioning

confidence: 99%

Factors affecting the efficiency of aerosolized salbutamol delivery via a metered dose inhaler and equine spacer device

Pirie

McGorum

Owen

et al. 2016

Vet Pharm & Therapeutics

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Despite frequent use of metered dose inhalers (MDIs) and spacers in equine practice, limited information exists on the efficiency of aerosol delivery using such devices. We determined the particle size distribution within an MDI-generated salbutamol aerosol delivered via an equine spacer using 'best practice' delivery technique and assessed the effect of variations in MDI use technique (shaking prior to each actuation, rapid repetitive actuations, and MDI angulation) on aerosol delivery efficiency. Under optimal conditions, only 53(±18) μg salbutamol per 100 μg actuation was delivered beyond the spacer. Although this aerosol had a high [89.6% (±2.4)] fine particle (<5 μm) fraction, and a low mass median aerodynamic diameter [2.52 (±0.29) μm], and particle size variability [geometric SD - 1.66 (±0.16) μm], within all particle size fractions, there was a high coefficient of variance (31-79%) of the percentage salbutamol delivered between experimental runs, thus impeding any effort to predict drug delivery to the patient during equine inhalation therapy. Despite observable trends and with the exception of minor statistically significant changes in the least abundant particle sizes, none of the deviations from a 'best practice' delivery technique significantly altered the relative salbutamol delivery beyond the spacer, a finding which has potential relevance with regard to maintaining user compliance.

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Inhalation therapy of equine respiratory disorders

Cited by 9 publications

References 47 publications

Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration

Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration

Post-anaesthetic pulmonary oedema in horses: a review

Factors affecting the efficiency of aerosolized salbutamol delivery via a metered dose inhaler and equine spacer device

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