Inhalation of vanadium pentoxide and its toxic effects in a mouse model

Fortoul, Teresa I.; Rodríguez-Lara, Vianey; González-Villalva, Adriana; Rojas-Lemus, Marcela; Cano-Gutiérrez, Gumaro; Ustarroz-Cano, Martha; Colı́n-Barenque, Laura; Bizarro-Nevares, Patrícia; García-Pealez, I.; Montaño, Luis F.; Jimenez-Martínez, Ruben; López-Valdéz, Nelly; Ruiz-Guerrero, M. L.; Meléndez-García, Nayeli; García-Ibarra, Fátima; Martínez-Baez, V.; Alfaro, David; Muñiz-Rivera-Cambas, A.; López-Zepeda, Lorena Sofía; Quezada-Maldonado, Ericka Marel; Cervantes-Yépez, S.

doi:10.1016/j.ica.2014.03.027

Cited by 38 publications

(52 citation statements)

References 63 publications

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“…We found that vanadium exposed mice presented a shift of the normal cortex-medulla relationship, showing a much thinner medulla and the presence of medulla-like areas within the cortex regions. These changes suggest an alteration of the immune response [69,89]. In addition to these findings we have reported a decrease in the presence of CD11c, a dendritic cell marker, and MHCII an antigen presenting cell marker, in the thymus of vanadium-exposed mice.…”

Section: Immunotoxicity Of Metalssupporting

confidence: 68%

“…The blood brain barrier (BBB), after the inhalation of vanadium showed cilia loss, cell sloughing and ependymal epithelium detachment from the basal membrane, and the presence of oxidative damage in the choroid plexus, which was confirmed by the presence of 4-hydroxynonenal. The reported alterations were associated with an increase in MMP-9 and MMP-2 activity in the cortex, the olfactory bulb, hippocampus and striatum [89,90].…”

Section: Neurotoxicity Of Metalsmentioning

confidence: 96%

“…It goes through the placenta, constituting complexes with transferrin or albumin, and accumulates in the placenta and the fetal tissues. It has been found that vanadium affects the prenatal development, since it produces embryo mortality, fetus toxicity and teratogenicity in mice, rats, hamsters and chickens [69,89]. In humans, it has been proved that the exposure to vanadium during pregnancy is linked to low birth weight.…”

Section: Teratogenesismentioning

confidence: 99%

“…In humans, it has been proved that the exposure to vanadium during pregnancy is linked to low birth weight. In the chicken embryo, the vanadium pentoxide produces embryo mortality and teratogenicity, since it provokes alterations in tubulation and the central nervous system, microphthalmia, abnormalities in the pharyngeal arches and facial development processes or their derivatives, congenital heart defect, limbs malformations and visceral ectopia [89]. Vanadium produces oxidative damage in proteins, lipids and DNA, interferes with DNA repair and affects cellular signaling pathways and cells proliferation [230].…”

Section: Teratogenesismentioning

confidence: 99%

See 3 more Smart Citations

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

Self Cite

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Section: Immunotoxicity Of Metalssupporting

confidence: 68%

Section: Neurotoxicity Of Metalsmentioning

confidence: 96%

Section: Teratogenesismentioning

confidence: 99%

Section: Teratogenesismentioning

confidence: 99%

See 2 more Smart Citations

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

Self Cite

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“…Increased concentrations of particulate matter (PM) in the atmosphere as a consequence of the combustion of fossil fuels have gained attention because of its consequences in the health of the population, as it has been reported by different authors (Calderon-Garcidueñas et al 2012;Fortoul et al 2014;Crouse et al 2015). Particles with aerodynamic diameter of 2.5 lm (PM 2.5 ) are especially noxious as they can penetrate deeper into the lungs and then translocate to the bloodstream, as well as interact directly with the respiratory and alveolar epithelium (Kim & Kim 2015).…”

Section: Introductionmentioning

confidence: 99%

Thymic cytoarchitecture changes in mice exposed to vanadium

Ustarroz-Cano¹,

García-Peláez²,

Cervantes-Yépez³

et al. 2017

Journal of Immunotoxicology

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The thymus is a vital immune system organ wherein selection of T-lymphocytes occurs in a process regulated by dendritic and epithelial thymic cells. Previously, we have reported that in a mouse model of vanadium inhalation, a decrease in CD11c dendritic cells was observed. In the present study, we report on a thymic cortex-medulla distribution distortion in these hosts due to apparent effects of the inhaled vanadium on cytokeratin-5 (K5 þ ) epithelial cells in the same mouse model -after 1, 2, and 4 weeks of exposure -by immunohistochemistry. These cells -together with dendritic cells -eliminate autoreactive T-cell clones and regulate the production of regulatory T-cells in situ. Because both cell types are involved in the negative selection of autoreactive clones, a potential for an increase in development of autoimmune conditions could be a possible consequence among individuals who might be exposed often to vanadium in air pollution, including dwellers of highly polluted cities with elevated levels of particulate matter onto which vanadium is often adsorbed. ARTICLE HISTORY

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Vanadium(IV) oxide affects embryonic development in mice

Álvarez‐Barrera¹,

Rodríguez‐Mercado²,

Mateos-Nava³

et al. 2022

Environmental Toxicology

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Vanadium(V) and vanadium(IV) are the predominant redox forms present in the environment, and epidemiological studies have reported that prenatal vanadium exposure is associated with restricted fetal growth and adverse birth outcomes. However, data about the toxic effects of vanadium(IV) oxide (V2O4) on the development of mammals are still limited. Therefore, in this work, 4.7, 9.4, or 18.7 mg/kg body weight/injection/day V2O4 was administered through an intraperitoneal (ip) injection to pregnant mice from gestational days 6 to 16. The results showed that V2O4 produced maternal and embryo‐fetal toxicity and external abnormalities in the offspring, such as malrotated and malpositioned hind limbs, hematomas and head injuries. Moreover, the skeletons of the fetuses presented reduced ossification of the cranial bones, including the frontal and parietal bones, corresponding to head injuries observed in the external assessment of the fetuses. These results demonstrate that administration of V2O4 to pregnant females in the organogenesis period adversely affects embryonic development.

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Inhalation of vanadium pentoxide and its toxic effects in a mouse model

Cited by 38 publications

References 63 publications

Health Effects of Metals in Particulate Matter

Health Effects of Metals in Particulate Matter

Thymic cytoarchitecture changes in mice exposed to vanadium

Vanadium(IV) oxide affects embryonic development in mice

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