Inhalation of salt aerosol particles—II. growth and deposition in the human respiratory tract

Ferron, G.A.; Kreyling, Wolfgang G.; Haider, B.

doi:10.1016/0021-8502(88)90213-3

Cited by 123 publications

(71 citation statements)

References 35 publications

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“…Among those are light scattering by aerosol particles (direct effect on climate), cloud droplet formation and growth, and, consequently cloud properties (indirect effect on climate). Uptake of water on aerosol particles also influences wet and dry deposition of aerosols and lung deposition (Schroeter et al, 2001;Ferron et al, 1988;Broday and Georgopoulos, 2001;. In the last years there has been a special focus on the indirect effect of aerosol particles on climate (Twomey, 1977;Kaufman et al, 2002;Ramanathan et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Hygroscopic growth and critical supersaturations for mixed aerosol particles of inorganic and organic compounds of atmospheric relevance

et al. 2006

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Abstract. The organic fraction of atmospheric aerosols contains a multitude of compounds and usually only a small fraction can be identified and quantified. However, a limited number of representative organic compounds can be used to describe the water-soluble organic fraction. In this work, initiated within the EU 5FP project SMOCC, four mixtures containing various amounts of inorganic salts (ammonium sulfate, ammonium nitrate, and sodium chloride) and three model organic compounds (levoglucosan, succinic acid and fulvic acid) were studied. The interaction between water vapor and aerosol particles was studied at different relative humidities: at subsaturation using a hygroscopic tandem differential mobility analyzer (H-TDMA) and at supersaturation using a cloud condensation nuclei spectrometer (CCN spectrometer). Surface tensions as a function of carbon concentrations were measured using a bubble tensiometer. Parameterizations of water activity as a function of molality, based on hygroscopic growth, are given for the pure organic compounds and for the mixtures, indicating van't Hoff factors around 1 for the organics. The Zdanovskii-Stokes-Robinson (ZSR) mixing rule was tested on the hygroscopic growth of the mixtures and it was found to adequately explain the hygroscopic growth for 3 out of 4 mixtures, when the limited solubility of succinic acid is taken into account. One mixture containing sodium chloride was studied and showed a pronounced deviation from the ZSR mixing rule. Critical supersaturations calculated using the parameterizations of water activity and the measured surface tensions were compared with those determined experimentally.

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Section: Introductionmentioning

confidence: 99%

Hygroscopic growth and critical supersaturations for mixed aerosol particles of inorganic and organic compounds of atmospheric relevance

et al. 2006

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“…Figure 2 shows that particle deposition in the lung will increase for soluble particles originally in the 0.5 to 1 um size range, as they enlarge by taking on liquid water. Ferron et al 118 have developed a lung model that includes these hygroscopic effects. Soluble particles within the droplet mode of Figure 1 may cause greater pulmonary aggravation than insoluble particles that are non-hygroscopic, or soluble particles originally in the condensation mode.…”

Section: Inhalation Propertiesmentioning

confidence: 99%

Measurement Methods to Determine Compliance with Ambient Air Quality Standards for Suspended Particles

Chow

1995

Journal of the Air & Waste Management Association

649

426

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One of the most important parts of formulating a National Ambient Air Quality Standard is specifying the measurement methods for determining and attaining compliance. The samples taken for compliance are often pushed beyond their original purpose to identify sources, to evaluate the effectiveness of controls, and to determine relationships between pollution levels and public health. A full understanding of available sampling and analysis methods is needed, as well as an analysis of their costs, before acceptable monitoring approached can be specified. This review identifies issues related to measurement methods used to determine compliance with standards, describes current and future measurement methods and their limitations, and determines the extent to which existing technology can meet shortterm and long-term needs for measuring compliance.

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“…The modelling of deposition of inhaled aerosols over the years has evolved from simple and limited algebraic models (James et al (1991)) to more complex and accurate empirical (Martonen et al (1994)), one-way coupled (Ferron et al (1988)), and two-way coupled hygroscopic models (Finlay & Stapleton (1995)), based on the Lagrangian approach. All these models treat the lung as unidimensional, calculating deposition on a typical or average aerosol path.…”

Section: Modelling Drug Deposition In the Lungmentioning

confidence: 99%

Improving the Likelihood of Success in Trials and the Efficiency of Delivery of Mucolytics and Antibiotics

Lange¹

2012

Cystic Fibrosis - Renewed Hopes Through Research

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Inhalation of salt aerosol particles—II. growth and deposition in the human respiratory tract

Cited by 123 publications

References 35 publications

Hygroscopic growth and critical supersaturations for mixed aerosol particles of inorganic and organic compounds of atmospheric relevance

Hygroscopic growth and critical supersaturations for mixed aerosol particles of inorganic and organic compounds of atmospheric relevance

Measurement Methods to Determine Compliance with Ambient Air Quality Standards for Suspended Particles

Improving the Likelihood of Success in Trials and the Efficiency of Delivery of Mucolytics and Antibiotics

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