Inhalation carcinogenicity bioassay of vinyl bromide in rats

Benya, Theodore J.; Busey, William M.; Dorato, Michael A.; Berteau, Peter E.

doi:10.1016/0041-008x(82)90233-2

Cited by 24 publications

(14 citation statements)

References 9 publications

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“…(This convention has also been followed for the lifetable calculations of the experiments of aromatic amines.) Data using the pooled controls are indicated by the letter "p" following the control incidence in column (22); see, for example, "aldrin" for male mice in the large plot, line 135. The use of pooled controls is also reflected on the left side of the output by the word "pool" following the notes in column (10) and by assigning a different line number to the pooled data.…”

Section: Nciintp Bioassaysmentioning

confidence: 99%

“…( [22][23][24][25][26] Beginning in (22) on the right side, and extending through (26), we report the proportion of animals with tumors and the average dose level in mg/kg body weight/day which we have calculated for each dose group in the experiment. The proportion of animals with tumors for TD50 values which have been calculated with lifetable data are presented here in summary form, i.e., the number of animals with tumors by the end of the experiment.…”

Section: Nciintp Bioassaysmentioning

confidence: 99%

“…Reading across (22)- (26), under "Cntrl" (22), we list the proportion of control animals with the tumor types in the TD50 calculation; the average dose in the lowest dose group. is given under "iDose" (23); the proportion of animals in that group with the tumor(s) is listed under "lInc," for incidence, (24); the next highest average dose 2Dose" (25) and the proportion of those animals with the tumor(s) "2Inc" (26) is given next, etc., for as many dose groups as there are in the experiment.…”

Section: Nciintp Bioassaysmentioning

confidence: 99%

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A Carcinogenic Potency Database of the Standardized Results of Animal Bioassays

Gold¹,

Sawyer²,

Magaw³

et al. 1984

Environmental Health Perspectives

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The preceding paper described our numerical index of carcinogenic potency, the TD54, and the statistical procedures adopted for estimating it from experimental data. This paper presents the Carcinogenic Potency Database, which includes results of about 3000 long-term, chronic experiments of 770 test compounds. Part II is a discussion of the sources of our data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. Part III is a guide to the plot of results presented in Part IV. A number of appendices are provided to facilitate use of the database. The plot includes information about chronic cancer tests in mammals, such as dose and other aspects of experimental protocol, histopathology and tumor incidence, TD5o and its statistical significance, dose response, author's opinion and literature reference. The plot readily permits comparisons of carcinogenic potency and many other aspects of cancer tests; it also provides quantitative information about negative tests. The range of carcinogenic potency is over 10 million-fold. Part 1: IntroductionThis paper presents the Carcinogenic Potency Database, which includes data on approximately 3000 longterm, chronic animal experiments with about 770 chemicals. The preceding paper (1) described our numerical index of carcinogenic potency, the TD50, and the statistical procedures adopted for estimating it from experimental data. weight/day) which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period. A TD50 can be computed for any particular type of neoplasm, for any particular tissue, or for any combination of these.Part II of this paper discusses the sources of bioassay results and the rationale for including particular experiments and particular target sites in the database. The conventions adopted in summarizing and standardizing the literature are also described. In Part IV we present a plot of the database. In

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Section: Nciintp Bioassaysmentioning

confidence: 99%

Section: Nciintp Bioassaysmentioning

confidence: 99%

Section: Nciintp Bioassaysmentioning

confidence: 99%

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A Carcinogenic Potency Database of the Standardized Results of Animal Bioassays

Gold¹,

Sawyer²,

Magaw³

et al. 1984

Environmental Health Perspectives

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“…The oncogenic potential of vinyl fluoride was evaluated in both rats and mice by inhalation at concentrations of 0, 25, 250 and 2500 ppm, and fluoroethylene was found to be carcinogenic at the lowest concentration (25 ppm) in both species (Bogdanffy et al 1995). The tumorigenic response was reported to be similar to that seen with vinyl chloride and vinyl bromide (ACGIH 2001bb;Maltoni et al 1981;Benya et al 1982).…”

Section: Toxicology Summary and Data Analysismentioning

confidence: 82%

“…However, it has been suggested that the slower relative metabolism of fluoroethylene vs. vinyl chloride to a similar toxic metabolite supports fluoroethylene being less potent than vinyl chloride (Filser and Bolt 1979). Likewise, a direct comparison of rodent bioassay results between fluoroethylene (Bogdanffy et al 1995) and vinyl bromide (Benya et al 1982) suggests that vinyl bromide is more than twice as potent as fluoroethylene. Therefore, ACGIH recommended a 1 ppm TLV-TWA for fluoroethylene, which is twice the recommended TLV-TWA (0.5 ppm) for vinyl bromide.…”

Section: Available Guidelinesmentioning

confidence: 99%

Proposed Occupational Exposure Limits for Non-Carcinogenic Hanford Waste Tank Vapor Chemicals

Poet¹,

Timchalk²

2006

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Unsaturated Halogenated Hydrocarbons

Belpoggi,

Tibaldi,

Gnudi

et al. 2023

Patty's Toxicology

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This chapter contains details on 12 unsaturated halogenated hydrocarbons. The considered chemicals are 1,3‐dichloropropene (DCP), cis ‐ and trans ‐1,2‐dichloroethylene (DCE), dichloroacetylene (DCA), allyl chloride (AC), hexachlorobutadiene (HCBD), β‐chloropropene, vinylidene chloride (VDC), vinyl chloride (VC), vinyl bromide (VB), vinyl fluoride (VF), trichloroethene (TCE), and tetrachloroethene (PCE). These compounds are used as fumigants, pesticides, solvents, and chemical intermediates. This chapter follows the outline determined for compounds and includes physical and chemical properties, production and use, exposure assessment in air and workplace, toxic effects (experimental and epidemiological studies), community methods for monitoring, regulations, and guidelines.

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Inhalation carcinogenicity bioassay of vinyl bromide in rats

Cited by 24 publications

References 9 publications

A Carcinogenic Potency Database of the Standardized Results of Animal Bioassays

A Carcinogenic Potency Database of the Standardized Results of Animal Bioassays

Proposed Occupational Exposure Limits for Non-Carcinogenic Hanford Waste Tank Vapor Chemicals

Unsaturated Halogenated Hydrocarbons

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