Inhalation airflow and ventilation efficiency in subject-specific human upper airways

Xu, Chang; Khoa, Nguyễn Đăng; Yoo, Sungjun; Zheng, Xin; Shen, Shifei; Ito, Kazuhide

doi:10.1016/j.resp.2020.103587

Cited by 10 publications

(6 citation statements)

References 41 publications

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“…The fibers then followed the airstream on, before being deposited on the inner wall, because of the sedimentation scheme. Besides, the fibers tended to deposit onto the anterior side rather than the posterior side; this can be attributed to the skewness of the airflow toward the anterior side originating from the glottis region, as discussed in our previous publication 56 . Similar local deposition sites were used by both CF and asbestos in the bronchial region, which coincided with airflow distribution, as discussed in Section 3.4.…”

Section: Resultssupporting

confidence: 61%

“…Upper airway airflow distribution has been dealt with quite extensively in our previous work 12,45,56 —so, this aspect is briefly discussed here.…”

Section: Resultsmentioning

confidence: 99%

“…Besides, the fibers tended to deposit onto the anterior side rather than the posterior side; this can be attributed to the skewness of the airflow toward the anterior side originating from the glottis region, as discussed in our previous publication. 56 Similar local deposition sites were used by both CF and asbestos in the bronchial region, which coincided with airflow distribution, as discussed in Section 3.4. This deposition tendency also fitted the concept that the interception and sedimentation deposition mechanisms governed the deposition trend in the initial tracheobronchial tree bifurcations.…”

Section: Comparing Total Deposition Efficiencies For Carbon and Asbes...mentioning

confidence: 98%

“…The existence of the external breathing domain caused the velocity profile in the nostril region to show a cone-like profile, in both models. Upper airway airflow distribution has been dealt with quite extensively in our previous work 12,45,56 -so, this aspect is briefly discussed here.…”

Section: Airflow Distribution In Human Respiratory Tractsmentioning

confidence: 99%

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Transport and deposition of inhaled man‐made vitreous and asbestos fibers in realistic human respiratory tract models: An in silico study

Khoa

Phuong

Takahashi

et al. 2022

Japan Architectural Review

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Particles longer than 5 μm and with a length/diameter ratio >3 are defined as fibers. Asbestos or other fibers are still identified in residential environments due to the emission from asbestos-used building materials. The respiratory system is the primary route of asbestos exposure; under a longer residence time, asbestosrelated adverse health effects are inevitable. Currently, asbestos fibers have been replaced with man-made vitreous fibers (MMVFs); however, studies have revealed some similar biological effects of MMVFs with asbestos. Therefore, MMVFs-induced diseases need to be determined by analyzing their deposition characteristics and foci in human respiratory tracts. In this study, we used computational fluid dynamics method to investigate fibers' airflow and deposition patterns in two realistic human respiratory models. Two drag models were used to predict the deposition of uniform 1 μm (asbestos) and 3.66 μm (carbon fiber-CF) diameter, 15-300 μm long fibers. Two drag models provided comparable results with the experimental data. Comparatively, asbestos deposition was independent of fiber length, while CF deposition increased proportionally to fiber length. The highest level of local deposition was detected in the anterior nasal cavity. The results obtained from this study can extend current knowledge of human vitreous fiber exposure-related lung diseases. Keywords asbestos, computational fluid dynamics, drag force, human respiratory system, man-made vitreous fiber (MMVF)-like carbon fiberThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Resultssupporting

confidence: 61%

“…Upper airway airflow distribution has been dealt with quite extensively in our previous work 12,45,56 —so, this aspect is briefly discussed here.…”

Section: Resultsmentioning

confidence: 99%

Section: Comparing Total Deposition Efficiencies For Carbon and Asbes...mentioning

confidence: 98%

Section: Airflow Distribution In Human Respiratory Tractsmentioning

confidence: 99%

See 2 more Smart Citations

Transport and deposition of inhaled man‐made vitreous and asbestos fibers in realistic human respiratory tract models: An in silico study

Khoa

Phuong

Takahashi

et al. 2022

Japan Architectural Review

Self Cite

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“…Wang et al [203] simulated a sinusoidal breathing pattern in a model ranging from nose to triple bifurcation (without sinuses), showing that flow in the trachea and pharynx was different during inhalation (along posterior of airway) than exhalation (along centreline). In [212] three realistic models from nose to trachea are shown to have different flow fields during steady inhalation. The heat transfer within the upper airway has been simulated both during inhalation of hot air [57] and during respiration in air at room temperature [152].…”

Section: Introductionmentioning

confidence: 99%

Pressure recordings for monitoring tidal breathing and optimizing settings for nasal high-flow therapy

Hebbink

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afsluitende neusbrillen worden gebruikt, worden de reconstructies inaccuraat op middelhoge NHFT-debieten. Meer onderzoek is daarom vereist om de klinische toepasbaarheid te vergroten.Concluderend, natuurlijke debiet-volumecurves zijn een interessant alternatief voor het monitoren van de gezondheid van de luchtwegen. Door het introduceren van de hier ontwikkelde meetmethode en het verder verkennen van de relatie met geforceerde spirometrie, kunnen verdere stappen naar klinische implementatie worden gezet, te beginnen met het bepalen van de klinische waarde van natuurlijke curves in het voorspellen van COPD-exacerbaties. Het monitoren van natuurlijke curves tijdens NHFT kan een goede optie zijn voor het optimaliseren van de instellingen aan het individu, maar de methode moet verder onderzocht worden om de geldigheid te vergroten. Gecombineerd LBM/LES kan worden gebruikt om de stromingstopologie tijdens NHFT te bestuderen voor verschillende neusbrilgroottes. Contents Summary vii Samenvatting ix Contents xiiiChapter 1 1.3. Nasal high-flow therapy 1.4. Objectives 2.3. Validation method 13 26 3. On the relation between tidal and forced spirometry

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Computational analysis of human upper airway aerodynamics

Hebbink

Wessels²,

Hagmeijer³

et al. 2022

Med Biol Eng Comput

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Inhalation airflow and ventilation efficiency in subject-specific human upper airways

Cited by 10 publications

References 41 publications

Transport and deposition of inhaled man‐made vitreous and asbestos fibers in realistic human respiratory tract models: An in silico study

Transport and deposition of inhaled man‐made vitreous and asbestos fibers in realistic human respiratory tract models: An in silico study

Pressure recordings for monitoring tidal breathing and optimizing settings for nasal high-flow therapy

Computational analysis of human upper airway aerodynamics

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