Inhalable polymer-glycerosomes as safe and effective carriers for rifampicin delivery to the lungs

Melis, Virginia; Manca, Maria Letizia; Bullita, Enrica; Tamburini, Elena; Castangia, Inés; Cardia, Maria Cristina; Valenti, Donatella; Fadda, Anna Maria; Peris, José-Esteban; Manconi, Maria

doi:10.1016/j.colsurfb.2016.03.044

Cited by 54 publications

(28 citation statements)

References 26 publications

(30 reference statements)

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“…Following IT administration to rats, glycerosomes promoted the accumulation of rifampicin in the lung, with lower systemic distribution, and low accumulation in other organs. The formulation containing hyaluronic acid was found to perform more favorably [75]. Although it was not discussed, the use of hyaluronic acid might be beneficial due to a favorable interaction of its N-acteylglucosamine units with CD44 [76,77] and mannose receptors [78].…”

Section: Delivery Of Antibioticsmentioning

confidence: 98%

Multifunctional Nanocarriers for Lung Drug Delivery

Pontes

Grenha

2020

Nanomaterials

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Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the surface engineering of the carriers by means of altering the material structure (i.e., chemical modifications), the addition of specific ligands so that predefined targets are reached, or even the tuning of the carrier properties to respond to specific stimuli. The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs—the latter two comprising local delivery approaches. This review addresses the applications of nanocarriers aimed at lung drug delivery of active biological and pharmaceutical ingredients, focusing with particular interest on nanocarriers that exhibit multifunctional properties. A final section addresses the expectations regarding the future use of nanocarriers in the area.

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Section: Delivery Of Antibioticsmentioning

confidence: 98%

Multifunctional Nanocarriers for Lung Drug Delivery

Pontes

Grenha

2020

Nanomaterials

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“…Results indicated that polymer glycerosomes led to increase in drug concentration in pulmonary system. Polymers resulted in the formation of stable vesicles that led to more deposition of drug in lungs, an increase in mean diameter of vesicles, these were aerosolized easily and were delivered to the farthest extent using a next generation impactor [73] .…”

Section: Inhaled Drug Delivery Using Glycerosomesmentioning

confidence: 99%

“…This led to the formulation of polymer-coated glycerosomes. These vesicles internally form a mesh of polymers with improvement of the in vivo characteristics of the system [27,73] . Key features of polymeric glycerosomes included, enhanced biocompatibilities, improved drug deposition at the target site, avoidance of first pass metabolism and delivery of the contents at the required location of lungs, safety and nontoxic in nature.…”

Section: Glycerosome-based Drug Delivery Nanocarriersmentioning

confidence: 99%

Glycerosomes: Advanced Liposomal Drug Delivery System

Gupta¹,

Mazumder²,

Padhi³

2020

Indian J Pharm Sci

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Gupta et al.: Glycerosomal Drug Delivery Systems Although liposomes have proved to be versatile in the field of drug delivery, there are still some issues that need to be addressed mainly problems related to entrapment, penetration, fluidity and stability. Glycerosomes represent a novel drug delivery systems composed of phospholipids, water and glycerol in varying amounts. Glycerosomes are upgraded versions of liposomes meant for topical and transdermal drug delivery. In these preparations, glycerol acts as an edge activator and penetration enhancer. These drug delivery systems manifest improved stability, fluidity, entrapment and penetration in comparison to conventional liposomes. Increasing the concentration of glycerol by 10, 20 or 30 % leads to a drastic increase in glycerosome stability. This article is a detailed review of glycerosomes focusing on methods of preparation, evaluation, applications, advantages and disadvantages based on studies reported so far. In this review article, how the structure of liposomes can be modified by the addition of glycerol and how this modified structure can be used to address the problems related to liposomes is discussed. The influence of increasing glycerol concentration on the nature of glycerosomes that lead to an increase in both entrapment and encapsulation of a drug while causing slower drug release is discussed.

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“…Demonstration of in vivo antimicrobial efficacy would be highly beneficial in order to determine the clinical usefulness of this technology to improve inhaled infection treatment. Other interesting nanocarrier systems recently reported for respiratory use include polymerlipid-glyceromes [173] and mucus-penetrating polymer-drug crystals [174], both of which can modulate drug disposition following inhalation and offer exciting, formulation-based approaches to overcome challenges associated with delivery of antimicrobial molecules to the lung.…”

Section: Nanoparticle Carriersmentioning

confidence: 99%

Antimicrobial Molecules in the Lung: Formulation Challenges and Future Directions for Innovation

Woods

Rahman

2018

Future Med. Chem.

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Inhaled antimicrobials have been extremely beneficial in treating respiratory infections, particularly chronic infections in a lung with cystic fibrosis. The pulmonary delivery of antibiotics has been demonstrated to improve treatment efficacy, reduce systemic side effects and, critically, reduce drug exposure to commensal bacteria compared with systemic administration, reducing selective pressure for antimicrobial resistance. This review will explore the specific challenges of pulmonary delivery of a number of differing antimicrobial molecules, and the formulation and technological approaches that have been used to overcome these difficulties. It will also explore the future challenges being faced in the development of inhaled products and respiratory infection treatment, and identify future directions of innovation, with a particular focus on respiratory infections caused by multiple drug-resistant pathogens.

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Inhalable polymer-glycerosomes as safe and effective carriers for rifampicin delivery to the lungs

Cited by 54 publications

References 26 publications

Multifunctional Nanocarriers for Lung Drug Delivery

Multifunctional Nanocarriers for Lung Drug Delivery

Glycerosomes: Advanced Liposomal Drug Delivery System

Antimicrobial Molecules in the Lung: Formulation Challenges and Future Directions for Innovation

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