Inguinal and incisional hernias

Kashyap, A S; Anand, Kuldip Parkash; Kashyap, Surekha

doi:10.1016/s0140-6736(03)15211-7

Cited by 13 publications

(6 citation statements)

References 2 publications

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“…Some collagen fiber defects lead to Ehlers-Danlos syndrome, which has skin and other pathological manifestations (37). Both Marfan syndrome and Ehlers-Danlos syndrome patients are at higher risk of developing inguinal hernias (38,39). It is unique that Efemp1 2/2 mice develop large inguinal hernias and other protrusions, but are devoid of obvious defects in other systems.…”

Section: Discussionmentioning

confidence: 99%

Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice

Pj¹,

Bakall²,

Choi

et al. 2007

Human Molecular Genetics

145

154

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A mutation in the EFEMP1 gene causes Malattia Leventinese, an inherited macular degenerative disease with strong similarities to age-related macular degeneration. EFEMP1 encodes fibulin-3, an extracellular matrix protein of unknown function. To investigate its biological role, the murine Efemp1 gene was inactivated through targeted disruption. Efemp1(-/-) mice exhibited reduced reproductivity, and displayed an early onset of aging-associated phenotypes including reduced lifespan, decreased body mass, lordokyphosis, reduced hair growth, and generalized fat, muscle and organ atrophy. However, these mice appeared to have normal wound healing ability. Efemp1(-/-) mice on a C57BL/6 genetic background developed multiple large hernias including inguinal hernias, pelvic prolapse and protrusions of the xiphoid process. In contrast, Efemp1(-/-) mice on a BALB/c background rarely had any forms of hernias, indicating the presence of modifiers for fibulin-3's function in different mouse strains. Histological analysis revealed a marked reduction of elastic fibers in fascia, a thin layer of connective tissue maintaining and protecting structures throughout the body. No apparent macular degeneration associated defects were found in Efemp1(-/-) mice, suggesting that loss of fibulin-3 function is not the mechanism by which the mutation in EFEMP1 causes macular degeneration. These data demonstrate that fibulin-3 plays an important role in maintaining the integrity of fascia connective tissues and regulates aging.

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Section: Discussionmentioning

confidence: 99%

Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice

Pj¹,

Bakall²,

Choi

et al. 2007

Human Molecular Genetics

145

154

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“…To date, surgical intervention is the only effective approach to repair such a highly prevalent condition that yearly affects more than 20 million patients worldwide. 1 Instrumental for successful hernia surgery has been the use of surgical meshes (i.e. hernioplasty) to reinforce the damaged region.…”

Section: Introductionmentioning

confidence: 99%

In vivosoft tissue reinforcement with bacterial nanocellulose

et al. 2021

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“…After abdominal surgery, incisional hernia presents an incidence ranging from 11 to 20 % [8][9][10]. Surgeries performed for inguinal hernia repair is among the most common interventions [11][12][13] in both adults and children [14][15][16]. Inguinal hernias are usually symptomatic and their only cure is surgery [1].…”

Section: Introductionmentioning

confidence: 99%

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Serrano‐Aroca¹,

Pous‐Serrano²

2021

Preprint

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Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

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Inguinal and incisional hernias

Cited by 13 publications

References 2 publications

Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice

Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice

In vivosoft tissue reinforcement with bacterial nanocellulose

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

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