Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain–gut–microbiota axis via the subdiaphragmatic vagus nerve

Wang, Siming; Ishima, Tamaki; Qu, Youge; Shan, Jiajing; Chang, Lijia; Wang, Yan; Zhang, Jiancheng; Pu, Yaoyu; Fujita, Yūkō; Tan, Yunfei; Wang, Xingming; Ma, Li; Wan, Xiayun; Hammock, Bruce D.; Hashimoto, Kenji

doi:10.1016/j.jad.2021.06.006

Cited by 77 publications

(43 citation statements)

References 61 publications

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“…Using high-throughput sequencing technology, significant alterations in the gut microbial community compositions of mice exposed to chronic stressors could be identified, and the relative abundances of Bacteroides and Clostridium were lower and higher, respectively (Bailey et al, 2011 ). Accumulating evidences emphasize the importance of subdiaphragmatic vagus nerve in development of depression caused by gut microbiota dysbiosis via the “microbiota-gut-brain axis” (Wang et al, 2020 , 2021 ; Zhang et al, 2020 ; Pu et al, 2021 ). Our results showed that mice with depression-like behaviors had a very different community structure in their gut microbiota with the control mice, supporting these findings.…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression

Wu¹,

Ran

et al. 2022

Front. Microbiol.

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5-Hydroxytryptophan (5-HTP) has positive clinical effects on various neuropsychiatric and metabiotic disorders, especially depression. Although it increases serotonin levels in the brain and gastrointestinal tract, its pharmacology remains largely unknown. Our goal was to determine the effects of 5-HTP on the mouse gut microbiome, which has a close relationship with depression through the “microbiota-gut-brain axis.” We confirmed that depressive disorder restructures the gut microbial community, and 5-HTP efficiently improves depressive symptoms in mice. Oral administration of 5-HTP significantly restored gut microbiota dysbiosis in mice with depression-like behaviors. The diversity and richness of gut microbial communities and relative abundance of specific microbial taxa at both phylum and genus levels were partially recovered. 5-HTP exhibited some positive effects on restoring the alterations in the concentrations of short-chain fatty acids and brain-derived neurotrophic factors caused by depression in mice. Our results may provide new insights into the pharmacology of 5-HTP in treating depression and other disorders.

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Section: Discussionmentioning

confidence: 99%

Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression

Wu¹,

Ran

et al. 2022

Front. Microbiol.

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“…Lactobacillus intestinalis and Lactobacillus reuteri were suggested to be responsible for these depressive-like behaviors [278]. When similar microbiota transplantation was used in resilient Ephx2 knock-out mice, increased depressive-like behaviors, anhedonia, and IL-6 levels were reported [279]. Faecalibaculum rodentium was reported to cause the increase in stress susceptibility [279].…”

Section: Gut Microbiotamentioning

confidence: 99%

“…When similar microbiota transplantation was used in resilient Ephx2 knock-out mice, increased depressive-like behaviors, anhedonia, and IL-6 levels were reported [279]. Faecalibaculum rodentium was reported to cause the increase in stress susceptibility [279]. Mice subjected to antibioticinduced microbiome depletion were resilient to CSDS-induced anhedonia.…”

Section: Gut Microbiotamentioning

confidence: 99%

Novel Pharmacological Approaches to the Treatment of Depression

Elias

Zhang

Manners

2022

Life

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Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-based antidepressants were the first drugs developed to treat major depressive disorder. More recently, ketamine and other analogues were introduced as fast-acting antidepressants. Unfortunately, currently available therapeutics are inadequate; lack of efficacy, adverse effects, and risks leave patients with limited treatment options. Efforts are now focused on understanding the etiology of depression and identifying novel targets for pharmacological treatment. In this review, we discuss promising novel pharmacological targets for the treatment of major depressive disorder. Targeting receptors including N-methyl-D-aspartate receptors, peroxisome proliferator-activated receptors, G-protein-coupled receptor 39, metabotropic glutamate receptors, galanin and opioid receptors has potential antidepressant effects. Compounds targeting biological processes: inflammation, the hypothalamic-pituitary-adrenal axis, the cholesterol biosynthesis pathway, and gut microbiota have also shown therapeutic potential. Additionally, natural products including plants, herbs, and fatty acids improved depressive symptoms and behaviors. In this review, a brief history of clinically available antidepressants will be provided, with a primary focus on novel pharmaceutical approaches with promising antidepressant effects in preclinical and clinical studies.

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“…It is also possible that pathogenic microbes might modulate Vagal afferents causing subsequent pathologic changes in the CNS, which may then lead to anxiety/depression like diseases ( Winter et al, 2018 ). Similarly, there are multiple studies conducted in mice which suggest the role of the vagus nerve in depressive behavior ( Pu et al, 2021 ; Wang et al, 2021 ). Taken together, the evidences point out to the possible role the gut microbiota may play in modulating the Vagus nerve thereby influencing the mental diseases like depression and anxiety.…”

Section: Brain Gut and The Microbiome – Current Understandingmentioning

confidence: 99%

Impending Mental Health Issues During Coronavirus Disease 2019 – Time for Personalized Nutrition Based on the Gut Microbiota to Tide Over the Crisis?

Dhar¹

2022

Front. Neurosci.

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Coronavirus disease 2019 (COVID-19) is a major pandemic facing the world today caused by SARS-CoV-2 which has implications on our mental health as well. The uncertain future, fear of job loss, lockdown and negative news all around have taken a heavy toll on the mental health of individuals from across the world. Stress and anxiety can affect the COVID-19 patients even more. Recent study suggests COVID-19 infection may lead to post-traumatic stress disorder (PTSD). Certain prebiotics and probiotics have been shown to have anxiolytic effect through gut microbiota modulation. Incidentally, preliminary report also suggests a differential microbial profile in COVID-19 patients as compared to healthy individuals. Gut microbiota’s role in anxiety and depression is well studied. The importance of the “gut-brain” axis has been implicated in overall mental health. It is known that diet, environmental factors and genetics play an important role in shaping gut microbiota. Trials may be initiated to study if personalized diet and supplementation based on individual’s gut microbiome profile may improve the general mental well-being of people prone to anxiety during this pandemic. Also, COVID-19 patients may be provided personalized nutritional therapy based on their gut microbiota profile to see if PTSD and anxiety symptoms can be alleviated.

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Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain–gut–microbiota axis via the subdiaphragmatic vagus nerve

Cited by 77 publications

References 61 publications

Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression

Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression

Novel Pharmacological Approaches to the Treatment of Depression

Impending Mental Health Issues During Coronavirus Disease 2019 – Time for Personalized Nutrition Based on the Gut Microbiota to Tide Over the Crisis?

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