Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study

Abstract

Intake of oral supplements with the aim of a cutaneous antiaging effect are increasingly common. Hyaluronic acid (HA) is a promising candidate, as it is the key factor for preserving tissue hydration. In our practice study, we evaluated the effect of an oral HA preparation diluted in a cascade-fermented organic whole food concentrate supplemented with biotin, vitamin C, copper, and zinc (Regulatpro Hyaluron) on skin moisture content, elasticity, skin roughness, and wrinkle depths. Twenty female subjects with healthy skin in the age group of 45 to 60 years took the product once daily for 40 days. Different skin parameters were objectively assessed before the first intake, after 20 and after 40 days. Intake of the HA solution led to a significant increase in skin elasticity, skin hydration, and to a significant decrease in skin roughness and wrinkle depths. The supplement was well tolerated; no side effects were noted throughout the study.

Hyaluronic Acid in the Third Millennium

“…For example, in a preliminary double-blind, controlled, randomized, parallel trial over 12 weeks, rooster comb extract was added to low fat yoghurt, which was given to mild knee pain patients (n: 40), resulting in significative improvement in muscle strength in men [253]. In another recent clinical study, an oral HA preparation diluted in a cascade fermented organic whole food concentrate supplemented with biotin, vitamin C, copper and zinc (Regulatpro ® Hyaluron, Dr. Niedermaier ® ) led to a significant cutaneous antiaging effect in twenty female subjects after 40 days of daily consumption [254]. From such mixtures, it is difficult to elucidate HA’s specific contribution.…”

Cytoprotective, anti‐inflammatory, and antioxidant properties of high‐molecular‐weight hyaluronan enriched with red orange extract in human fibroblasts exposed to ultra violet light B irradiation

“…Furthermore, oral HA supplementation improved the appearance of skin by reducing wrinkles and increasing skin elasticity and hydration in Japanese and Caucasian women . In this study, we investigated the ability of the dietary supplement IALUTEC ® RED to antagonize skin photoaging.…”

Nutricosmetics: A brief overview

“…Dietary supplements contain several forms of zinc in percentage of elemental zinc variable. Zinc plays an important role in morphogenesis, repair, and maintenance of the skin, being an essential cofactor for several metalloenzymes (MMPs), superoxide dismutase, metallothionein, and RNA polymerases (Gollner, Voss, Hehn, & Kammerer, 2017).…”

“…Selenium deficiency is related to skin cancer. Selenium prevents oxidative stress and damage due to oxidative stress being a cofactor of glutathione peroxidases and thioredoxin reductases and helps removing harmful lipid hydroperoxides, hydrogen peroxide, and peroxynitrites (Gollner et al, 2017). (Figure 4…”