Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men

Nagao, Tomonori; Komine, Yumiko; Soga, Satoko; Meguro, Shu; Hase, Tadashi; Tanaka, Yukitaka; Tokimitsu, Ichiro

doi:10.1093/ajcn/81.1.122

Cited by 395 publications

(324 citation statements)

References 32 publications

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“…The weight loss effect due to CH-19 Sweet may have been clearly demonstrated by the precise experimental design, or capsiate may have been more effective than capsaicin. Nagao et al have reported that the ingestion of tea rich in catechins for four weeks reduced body fat by 0.5 kg, 37) and St-Onge et al have reported that the ingestion of medium-chain triacylglycerols for four weeks reduced body fat by 0.8 kg. 38) Since the ingestion of CH-19 Sweet for two weeks reduced body fat by 0.6 kg, CH-19 Sweet is suggested to be as effective for reducing body fat as such compounds as catechins and medium-chain triacylglycerols.…”

Section: Discussionmentioning

confidence: 99%

Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans

Kawabata

Inoue

Yazawa

et al. 2006

Bioscience, Biotechnology, and Biochemistry

101

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Section: Discussionmentioning

confidence: 99%

Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans

Kawabata

Inoue

Yazawa

et al. 2006

Bioscience, Biotechnology, and Biochemistry

101

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“…The obesity pandemic has accelerated cell, animal, and human research on the anti-obesity effects of flavonoids (Borchardt and Huber 1975;Melzig 1996;Hase et al 2001;Nagao et al 2001Nagao et al , 2005Nagao et al , 2007Singh et al 2003;Alexander 2006;Greenberg et al 2006;Harwood et al 2007;Bose et al 2008;Egert et al 2008;Ito et al 2008;Stewart et al 2008;Liu et al 2009;Faria et al 2010;Grove and Lambert 2010;Zhu et al 2010). For example, several animal studies indicate that 3-15 weeks of supplementation with green tea extract and epigallocatechin gallate (EGCG) reduce body mass and fat mass (Bose et al 2008;Ito et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The catechins in green tea may increase thermogenesis and fat oxidation by inhibiting catechol-O-methyltransferase, leading to increased expression of norepinephrine and heightened sympathetic nervous system activity (Borchardt and Huber 1975). Epidemiological research supports the anti-obesity influence of green tea intake (Grove and Lambert 2010), and controlled human trials indicate a small but significant decrease in body mass, waist circumference, and body fat in subjects randomized to green tea extract supplementation (Hase et al 2001;Nagao et al 2001Nagao et al , 2005Nagao et al , 2007. Other polyphenols such as soy isoflavones demonstrate positive effects on weight loss in humans.…”

Section: Introductionmentioning

confidence: 99%

Quercetin with vitamin C and niacin does not affect body mass or composition

Knab

Shanely

Jin

et al. 2011

Appl. Physiol. Nutr. Metab.

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In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45%normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements adminis-tered in double-blind fashion: Q500 = 500 mg quercetin·day-1, Q1000 = 1000 mg quercetin·day-1, and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition meas-urements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and com-position across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a dose-responsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant dif-ferences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, fe-males p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body mass or body composition were found in a subgroup of overweight and obese subjects. High-dose quercetin supplementation (500 and 1000 mg·day-1) for 12 weeks in a large, heterogeneous group of adults did not affect body mass or composition. Abstract: In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45% normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements administered in double-blind fashion: Q500 = 500 mg quercetin·day -1 , Q1000 = 1000 mg quercetin·day -1 , and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition measurements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and composition across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a doseresponsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant differences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, females p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body ma...

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“…We have been studying the antiobesity effects of tea Cat in humans and rodents. 18,19 We previously demonstrated that long-term intake of tea Cat is beneficial in reducing HF diet-induced obesity, and that this effect might be attributed, at least in part, to the activation of lipid metabolism in the liver. 18 Although there have been many investigations of the beneficial effects of both Ex and some food components, little is known about their combined effects on the development of obesity.…”

Section: Introductionmentioning

confidence: 99%

Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimming

et al. 2005

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Objective: Obesity is a metabolic disorder resulting from imbalance between metabolizable energy intake and energy expenditure. It is known to be a strong risk factor for lifestyle-related diseases. Here, we investigated the effects of long-term intake of tea catechins (Cat) in combination with regular exercise (Ex) on the development of obesity in C57BL/6 mice. Design: We compared body weight, adipose tissue mass, plasma parameters and b-oxidation activity in mice fed a low-fat diet (5% triglyceride (TG); LF), a high-fat diet (30% TG; HF), a HF diet supplemented with 0.5% (w/w) tea Cat, a HF diet in addition to swimming Ex or a HF diet plus 0.5% tea Cat in addition to swimming Ex (Cat þ Ex) for 15 weeks. Oxygen consumption and respiratory quotients were measured using indirect calorimetry. Results: Tea-Cat intake in combination with swimming Ex suppressed HF diet-induced body-weight gain by 18 and 22%, respectively, compared to Ex and tea-Cat intake on their own. Visceral fat accumulation and the development of hyperinsulinemia and hyperleptinemia were also reduced in the HF þ Cat þ Ex group. Muscular b-oxidation activity in this group was 69 and 52% higher, respectively, than that in the HF and HF þ Cat groups. Lipid oxidation, determined using indirect calorimetry, was higher in the HF þ Cat þ Ex group, suggesting increased lipid utilization at the individual level. Conclusion: These results indicate that intake of tea Cat, together with regular Ex helps to reduce diet-induced obesity. This effect might be attributed, at least in part, to the activation of whole-body energy metabolism.

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Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men

Abstract: Daily consumption of tea containing 690 mg catechins for 12 wk reduced body fat, which suggests that the ingestion of catechins might be useful in the prevention and improvement of lifestyle-related diseases, mainly obesity.

Cited by 395 publications

References 32 publications

Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans

Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans

Quercetin with vitamin C and niacin does not affect body mass or composition

Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimming

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