Ingesting Yogurt Containing Lactobacillus plantarum OLL2712 Reduces Abdominal Fat Accumulation and Chronic Inflammation in Overweight Adults in a Randomized Placebo-Controlled Trial

Abstract

Background Chronic inflammation and insulin resistance are factors that are related to obesity. We have suggested that the administration of heat-treated Lactobacillus plantarum OLL2712 (OLL2712) cells can improve glucose and lipid metabolism by suppressing chronic inflammation in mouse models and a pilot clinical study. Objective The aim of this study was to investigate whether ingesting OLL2712 cells can reduce body fat accumulation and improve metabolic risk factors, in overweight, healthy adults. Methods This study was a randomized, double-blind, placebo-controlled, parallel-group trial conducted at a single center in Japan. The study participants included 100 overweight (BMI range, ≥25 to < 30 kg/m2) adults aged 20–64 y. They were randomly assigned to either the placebo or OLL2712 group (n = 50 each) and were administered conventional yogurt or yogurt containing more than 5 × 109 heat-treated OLL2712 cells, respectively, daily for 12 wk. The primary outcome was the 12-wk change in the abdominal fat area, as assessed by computed tomography, and the secondary outcomes were glucose and lipid metabolism-related parameters and chronic inflammation markers, which were analyzed using a linear mixed model. Results The 12-wk change of abdominal fat area (difference: 8.5 cm2; 95% CI: 0.3, 16.6 cm2; P = 0.040) and fasting plasma glucose (difference: 3.2 mg/dL; 95% CI: 0.8, 5.6 mg/dL; P = 0.021) were significantly less in the OLL2712 group than the placebo group. The overall trend of serum interleukin-6 was significantly decreased in the OLL2712 group compared with baseline and the placebo group. Conclusions The ingestion of heat-treated OLL2712 cells reduces body fat accumulation and the deterioration of glycemic control and chronic inflammation, in overweight, healthy adults. We hypothesize that OLL2712 cells may prevent obesity by regulating chronic inflammation. This trial was registered at UMIN Clinical Trials Registry as UMIN000027709.

Dairy Lactic Acid Bacteria and Their Potential Function in Dietetics: The Food–Gut-Health Axis

“…Dairy LAB strains can exert a protective effect on pancreatic cells by inhibiting the production of these inflammatory cytokines [ 146 ]. A study determined that fasting blood glucose and serum IL-6 levels were significantly reduced in slightly obese individuals consuming yogurt containing Lactiplantibacillus plantarum OLL2712 (>5 × 10 9 cells/112 g of yogurt) [ 147 ]. It was shown in individuals with type 2 DM that consumption of 300 g of probiotic yogurt ( Lactobacillus delbrueckii subsp.…”

Efficacy and Safety of Lactobacillus plantarum K50 on Lipids in Koreans With Obesity: A Randomized, Double-Blind Controlled Clinical Trial

“…In a study with Indonesian subjects, consumption of indigenous probiotic L. plantarum Dad-13 powder in overweight adults decreased the body weight and BMI significantly ( 29 ). In a Japanese study, the ingestion of heat-treated L. plantarum OLL2712 reduced body fat accumulation, glycemic deterioration, and chronic inflammation in overweight, healthy adults ( 30 ). Thus, the effects of L. plantarum on altering the metabolic status differ among studies, suggesting that it depends on the study subjects and the strain used ( 31 , 32 ).…”

Bile acids, gut microbiota and metabolic surgery

“…For example, several species of Lactobacillus have been reported to have the ability to prevent weight gain and blood glucose disorder in mice that were fed high-fat diet (71). The results from a clinical trial supported the beneficial effect of Lactobacillus spp, showing that overweight subjects who consumed yogurt containing heatkilled Lactobacillus plantarum OLL1712 displayed significantly less abdominal fat accumulation and lower fasting plasma glucose (72). Similarly, Akkermansia muciniphila and Parabacteroides distasonis have both been deemed beneficial to metabolic health (73)(74)(75).…”