Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and β-hemolytic streptococci)

Glück, Ulrich; Gebbers, Jan‐Olaf

doi:10.1093/ajcn/77.2.517

Cited by 179 publications

(118 citation statements)

References 30 publications

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“…The choice of the specific probiotic agent used in this study (Lactobacillus rhamnosus GG) also differed from the agent(s) used in existing trials. This agent was chosen because it had the most robust safety data and had cursory data suggesting that it may have preferential activity in the upper airways (37)(38)(39). Given the paucity of comparative data in this area, it remains unknown whether other agents would have similar or superior results.…”

Section: Discussionmentioning

confidence: 99%

Probiotic Prophylaxis of Ventilator-associated Pneumonia

Morrow¹,

Kollef²,

Casale³

2010

Am J Respir Crit Care Med

318

329

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Rationale: Enteral administration of probiotics may modify the gastrointestinal environment in a manner that preferentially favors the growth of minimally virulent species. It is unknown whether probiotic modification of the upper aerodigestive flora can reduce nosocomial infections. Objectives: To determine whether oropharyngeal and gastric administration of Lactobacillus rhamnosus GG can reduce the incidence of ventilator-associated pneumonia (VAP). Methods: We performed a prospective, randomized, double-blind, placebo-controlled trial of 146 mechanically ventilated patients at high risk of developing VAP. Patients were randomly assigned to receive enteral probiotics (n 5 68) or an inert inulin-based placebo (n 5 70) twice a day in addition to routine care. Measurements and Main Results: Patients treated with Lactobacillus were significantly less likely to develop microbiologically confirmed VAP compared with patients treated with placebo (40.0 vs. 19.1%; P 5 0.007). Although patients treated with probiotics had significantly less Clostridium difficile-associated diarrhea than patients treated with placebo (18.6 vs. 5.8%; P 5 0.02), the duration of diarrhea per episode was not different between groups (13.2 6 7.4 vs. 9.8 6 4.9 d; P 5 0.39). Patients treated with probiotics had fewer days of antibiotics prescribed for VAP (8.6 6 10.3 vs. 5.6 6 7.8 d; P 5 0.05) and for C. difficile-associated diarrhea (2.1 6 4.8 SD d vs. 0.5 6 2.3 d; P 5 0.02). No adverse events related to probiotic administration were identified. Conclusions: These pilot data suggest that L. rhamnosus GG is safe and efficacious in preventing VAP in a select, high-risk ICU population. Clinical trial registered with www.clinicaltrials.gov (NCT00613795).

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Section: Discussionmentioning

confidence: 99%

Probiotic Prophylaxis of Ventilator-associated Pneumonia

Morrow¹,

Kollef²,

Casale³

2010

Am J Respir Crit Care Med

318

329

View full text Add to dashboard Cite

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“…But local and remote actions of probiotic organisms have been suggested. Some studies have shown a reduction in potentially pathogenic organisms even at sites distant to the gut (vagina and nasal cavity) following oral probiotic therapy (Gluck and Olaf Gebbers, 2003;Reid et al, 2003). One proposed mechanism is that probiotics initiate an immune response in the gut-associated lymphoid tissue, resulting in circulation of primed T and B cells and immune activation at distant mucosal surfaces (Perdigon et al, 1999;.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis

et al. 2007

Eur J Clin Nutr

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Objective: To study the effect of the Lactobacillus plantarum (LP) enteral feeding on the gut permeability and sepsis in the patients with acute pancreatitis. Subjects: Seventy-six subjects who stayed over 1 week in the hospital completed the study. Subjects were not treated with any lactobacillus supplement before the intervention. Methods: Seventy-six patients with acute pancreatitis were randomly divided into two groups, parenteral nutrition (PN) group (n ¼ 38) and ecoimmunonutrition (EIN) group supplied by LP enteral feeding (n ¼ 36). The acute physiology and chronic health evaluation score, Balthazar CT score, CRP, fecal bacterial species and DNA fingerprint profiles as well as the potentially pathologenic organisms in nasogastric aspirate were determined on the day of admission and on the 8 day. The intestinal permeability was assessed by measurement of the ratio of lactulose/rhamnose on the day of admission and on days 5 and 8. The rate of organ failure, septic complications and death cases were evaluated at the 8 day. Results: Following 7 days treatment, 38.9% patients in the EIN group were colonized with multiple organisms compared to 73.7% in the PN group (Po0.01), and 30.6% patients in the EIN grew potentially pathogenic organisms compared to 50% patients in PN group (Po0.05). The fecal bacterial DNA fingerprint profiles were less, the amount of lactobacteria and bifydobacteria decreased, and the amount of enterococci increased in PN group as compared with EIN group, Po0.05. By day 8, the lactulose/rhamnose ratio in EIN group were lower than that in PN group at days 5 and 8, Po0.05. The patients with LP got a better clinical outcomes as compared with the patients with PN. Conclusion: EIN enteral feeding can attenuate disease severity, improve the intestinal permeability and clinical outcomes.

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“…As obtained a study which looked upon the specific measurement of pathogenic bacteria in human nasal canals, the results showed that those patients who were given the supplemented yogurt experienced a markedly reduced level of nasal colonization of pathogenic bacteria -Staphylococci aureus, Streptococcus pneumonia and β haemolytic streptococci [23].…”

Section: Reduction In Colonization Of Nasal Pathogenic Bacteriamentioning

confidence: 99%

Probiotic Efficacy and Potential of Streptococcus thermophilus modulating human health: A synoptic review

Sharma¹,

Bhaskar²,

Sanodiya³

et al. 2014

IOSRJPBS

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Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and β-hemolytic streptococci)

Abstract: The results indicate that regular intake of probiotics can reduce PPB in the upper respiratory tract. The results also indicate a linkage of the lymphoid tissue between the gut and the upper respiratory tract.

Cited by 179 publications

References 30 publications

Probiotic Prophylaxis of Ventilator-associated Pneumonia

Probiotic Prophylaxis of Ventilator-associated Pneumonia

Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis

Probiotic Efficacy and Potential of Streptococcus thermophilus modulating human health: A synoptic review

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