Ingested nitrate, disinfection by-products, and risk of colon and rectal cancers in the Iowa Women's Health Study cohort

Jones, Rena R.; DellaValle, Curt T.; Weyer, Peter J.; Robien, Kim; Cantor, Kenneth P.; Krasner, Stuart W.; Freeman, Laura E. Beane; Ward, Mary H.

doi:10.1016/j.envint.2019.02.010

Cited by 73 publications

(43 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quist et al [ 41 ] assessed pancreas cancer in the IWHS and found no association with estimated nitrate ingestion from drinking water but found a positive association with dietary nitrite intake from processed meat. Jones et al [ 42 ] assessed colon and rectum cancers in the IWHS and found no association with nitrate ingestion from drinking water but a positive association with red meat intake. We also conducted a more detailed dietary analysis by examining separate sources of nitrate and nitrite in relation to the risk of individual digestive system cancers.…”

Section: Discussionmentioning

confidence: 99%

Ingestion of Nitrate and Nitrite and Risk of Stomach and Other Digestive System Cancers in the Iowa Women’s Health Study

Buller

Patel

Weyer

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Nitrate and nitrite are precursors in the endogenous formation of N-nitroso compounds (NOC) which are potent animal carcinogens for the organs of the digestive system. We evaluated dietary intakes of nitrate and nitrite, as well as nitrate ingestion from drinking water (public drinking water supplies (PWS)), in relation to the incidence (1986–2014) of cancers of the esophagus (n = 36), stomach (n = 84), small intestine (n = 32), liver (n = 31), gallbladder (n = 66), and bile duct (n = 58) in the Iowa Women’s Health Study (42,000 women aged from 50 to 75 in 1986). Dietary nitrate and nitrite were estimated using a food frequency questionnaire and a database of nitrate and nitrite levels in foods. Historical nitrate measurements from PWS were linked to the enrollment address by duration. We used Cox regression to compute hazard ratios (HR) and 95% confidence intervals (CI) for exposure quartiles (Q), tertiles (T), or medians, depending on the number of cancer cases. In adjusted models, nitrite intake from processed meats was associated with an increased risk of stomach cancer (HRQ4vsQ1 = 2.2, CI: 1.2–4.3). A high intake of total dietary nitrite was inversely associated with gallbladder cancer (HRQ4vsQ1 = 0.3, CI: 0.1–0.96), driven by an inverse association with plant sources of nitrite (HRQ4vsQ1 = 0.3, CI: 0.1–0.9). Additionally, small intestine cancer was inversely associated with a high intake of animal nitrite (HRT3vsT1 = 0.2, CI: 0.1–0.7). There were no other dietary associations. Nitrate concentrations in PWS (average, years ≥ 1/2 the maximum contaminant level) were not associated with cancer incidence. Our findings for stomach cancer are consistent with prior dietary studies, and we are the first to evaluate nitrate and nitrite ingestion for certain gastrointestinal cancers.

show abstract

Section: Discussionmentioning

confidence: 99%

Ingestion of Nitrate and Nitrite and Risk of Stomach and Other Digestive System Cancers in the Iowa Women’s Health Study

Buller

Patel

Weyer

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…We found that a 70 g/day higher red and processed meat intake was associated with a 31% greater risk of colorectal cancer and 38% greater risk of colon cancer. This association was in the same direction but of greater magnitude than the results from the WCRF/AICR meta-analysis (Risk ratio (RR) for colorectal cancer 1.12, 95%-CI 1.04-1.21 per 100g/day higher red and processed meat intake), and most more recent research, including a previous study in UK Biobank investigating associations between diet and colorectal cancer with a shorter follow-up and fewer cases [19,[22][23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 85%

Meat intake and cancer risk: prospective analyses in UK Biobank

Knüppel

Papier

Fensom

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Red and processed meat has been consistently associated with risk for colorectal cancer, but evidence for other cancer sites is limited and few studies have examined the association between poultry intake and cancer risk. We examined associations between total meat, red meat, processed meat and poultry intake and incidence for 20 common cancer sites. Methods and Findings: We analysed data from 475,023 participants (54% women) in UK Biobank. Participants were aged 37 73 years and cancer free at baseline. Information on meat consumption was based on a touchscreen questionnaire completed at baseline covering type and frequency of meat intake. Diet intake was re-measured a minimum of three times in a subsample (15%) using a web-based 24h dietary recall questionnaire. Multivariable-adjusted Cox proportional hazards models were used to determine the association between baseline meat intake and cancer incidence. Trends in risk across baseline meat intake categories were calculated by assigning a mean value to each category using estimates from the re-measured meat intakes. During a mean follow-up of 6.9 years, 28,955 participants were diagnosed with a malignant cancer. Total, red and processed meat intakes were each positively associated with risk of colorectal cancer (e.g. hazard ratio (HR) per 70 g/day higher intake of red and processed meat combined 1.31, 95%-confidence interval (CI) 1.14-1.52). Red meat intake was positively associated with breast cancer (HR per 50 g/day higher intake 1.12, 1.01-1.24) and prostate cancer (1.15, 1.03-1.29). Poultry intake was positively associated with risk for cancers of the lymphatic and hematopoietic tissues (HR per 30g/day higher intake 1.16, 1.03-1.32). Only the associations with colorectal cancer were robust to Bonferroni correction for multiple comparisons. Study limitations include unrepresentativeness of the study sample for the UK population, low case numbers for less common cancers and the possibility of residual confounding. Conclusions: Higher intakes of red and processed meat were associated with a higher risk of colorectal cancer. The observed positive associations of red meat consumption with breast and prostate cancer, and poultry intake with cancers of the lymphatic and hematopoietic tissues, require further investigation.

show abstract

“…Cancer risk factors include biological agents (infection), exposure to synthetic chemicals, and lifestyle factors, which together contribute to the development of 70-95% of cancers (Wu et al, 2016). Several chemicals have been reported promote the tumorigenesis and tumor development of CRC (Abolhassani et al, 2019;Cernigliaro et al, 2019;Jones et al, 2019). This provides a new clue for us to prevent the occurrence of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Several chemicals have been suggested to promote the tumorigenesis and development of CRC. For instance, analysis of an Iowa Women's Health Study cohort suggested that exposure to TTHM in drinking water is associated with increased risk of rectal cancer (Jones et al, 2019). In addition, another case-control study observed that organochlorine and organophosphorus pesticides may induce CRC (Abolhassani et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer

et al. 2020

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate in global cancer. Exploring the associations between chemicals and CRC has great significance in prophylaxis and therapy of tumor diseases. This study aims to explore the relationships between CRC and environmental chemicals on genetic basis by bioinformatics analysis. The genome-wide association study (GWAS) datasets for CRC were obtained from the UK Biobank. The GWAS data for colon cancer (category C18) includes 2,581 individuals and 449,683 controls, while that of rectal cancer (category C20) includes 1,244 individuals and 451,020 controls. In addition, we derived CRC gene expression datasets from the NCBI-GEO (GSE106582). The chemicals related gene sets were acquired from the comparative toxicogenomics database (CTD). Transcriptome-wide association study (TWAS) analysis was applied to CRC GWAS summary data and calculated the expression association testing statistics by FUSION software. We performed chemicals related gene set enrichment analysis (GSEA) by integrating GWAS summary data, mRNA expression profiles of CRC and the CTD chemical-gene interaction networks to identify relationships between chemicals and genes of CRC. We observed several significant correlations between chemicals and CRC. Meanwhile, we also detected 5 common chemicals between colon and rectal cancer, including methylnitronitrosoguanidine, isoniazid, PD 0325901, sulindac sulfide, and importazole. Our study performed TWAS and GSEA analysis, linked prior knowledge to newly generated data and thereby helped identifying chemicals related to tumor genes, which provides new clues for revealing the associations between environmental chemicals and cancer.

show abstract

Ingested nitrate, disinfection by-products, and risk of colon and rectal cancers in the Iowa Women's Health Study cohort

Cited by 73 publications

References 46 publications

Ingestion of Nitrate and Nitrite and Risk of Stomach and Other Digestive System Cancers in the Iowa Women’s Health Study

Ingestion of Nitrate and Nitrite and Risk of Stomach and Other Digestive System Cancers in the Iowa Women’s Health Study

Meat intake and cancer risk: prospective analyses in UK Biobank

Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer

Contact Info

Product

Resources

About