ING3 (inhibitor of growth family, member 3)

Abstract

Review on ING3, with data on DNA/RNA, on the protein encoded and where the gene is implicated. IdentityOther names: Eaf4, ING2, MEAF4, p47ING3 HGNC (Hugo): ING3 Location: 7q31.31 DNA/RNA DescriptionIn 1996, Karl Riabowol's group identified a new Tumor Suppressor Gene (TSG) by using subtractive hybridization between cDNAs from normal mammary epithelial cells and mammary epithelial cells from tumor. This experiment was followed by an in vivo screen for tumourigenesis. Using this method, the authors identified a new candidate TSG that they named ING1 for INhibitor of Growth 1 (Garkavtsev et al., 1996). Few years later, ING2, ING3, ING4 and ING5 were identified by homology search. ING3 was identified through bioinformatic analyses in order to find human EST clone showing a high homology with the p33ING1b and p33ING2 cDNAs (Nagashima et al., 2003).