ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction

Hara, Yasuo; Zheng, Zuoyu; Evans, Susan C.; Malatjalian, D. A.; Riddell, D. Christie; Guernsey, Duane L.; Wang, Li Dong; Riabowol, Karl; Casson, Alan G.

doi:10.1016/s0304-3835(02)00635-3

Cited by 22 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rare missense mutations in ING1 have been detected in esophageal carcinomas 42) , melanoma 43) , adenocarcinomas of the esophagogastric junction 44) , non-small cell lung cancer 45) , pancreatic carcinoma 46) , colon cancer cell line 47) , hepatocellular carcinoma 48) , and meningioma 49) , while no mutations were detected in leukemia 50) , Indian oral cancer 51) , astrocytoma 52) and lymphoid malignancies 53) . On the other hand, decreased expression of ING1 mRNA has been shown in breast cancers 41,54) , gastric cancers 47) , lymphoid malignancies 53) , brain tumors 52) , non-small cell lung cancer 45) and adenocarcinomas of the esophagogastric junction 44) .…”

Section: Deregulation Of Ing Family Genes In Tumorsmentioning

confidence: 99%

See 1 more Smart Citation

Inhibitor of Growth (ING) Family: An Emerging Molecular Target for Cancer Therapy

Gündüz

Beder

et al. 2008

J. Hard Tissue Biology.

View full text Add to dashboard Cite

ING1 gene, the founding member of the ING tumor suppressor family, was originally identified through subtractive hybridization between normal mammary epithelial cells and breast cancer cell lines, and subsequent in vivo selection of genetic suppressor element that displayed oncogenic features. Soon after identification of ING1, four additional members of the ING family (ING2-5) were cloned and all the gene products contain a highly conserved plant homeodomain (PHD) finger motif in the carboxy (C)-terminal end, that plays important role for their function. Furthermore, ING family members contain nuclear localization signals and N-terminal sequences important in the interaction with histone acetyltransferase (HAT) and histone deacetyltransferase (HDAC) that regulate gene promoter activity within chromatin. Although exact functions of ING family genes have not been clarified, the gene products are involved in transcriptional regulation, apoptosis, cell cyle, angiogenesis and DNA repair through p53-dependent and -independent pathways. Chromosomal deletion and decreased expression of each ING family member gene in various cancer types strongly suggested products of these genes as tumor suppressor factors. Rare mutation but frequent allelic loss and epigenetic changes have been shown in ING family genes, suggesting them as a class II tumor suppressor gene. This review summarizes the known biological functions of the ING tumor suppressors and signaling related pathways.

show abstract

Section: Deregulation Of Ing Family Genes In Tumorsmentioning

confidence: 99%

“…On the other hand, decreased expression of ING1 mRNA has been shown in breast cancers 41,54) , gastric cancers 47) , lymphoid malignancies 53) , brain tumors 52) , non-small cell lung cancer 45) and adenocarcinomas of the esophagogastric junction 44) .…”

Section: Deregulation Of Ing Family Genes In Tumorsmentioning

confidence: 99%

Inhibitor of Growth (ING) Family: An Emerging Molecular Target for Cancer Therapy

Gündüz

Beder

et al. 2008

J. Hard Tissue Biology.

View full text Add to dashboard Cite

show abstract

“…In addition, p33ING1b mRNA expression was reduced in 63% of AdEGJs samples compared to normal esophageal tissues. Moreover, ING1b protein expression was frequently decreased or not detected in tumor samples, while all normal gastric mucosa had ING1b protein expression (Hara et al, 2003).…”

Section: Adenocarcinoma Of the Esophagogastric Junctionmentioning

confidence: 95%

ING1 (inhibitor of growth family, member 1)

Mouche¹,

Yaacoub²,

Guillaudeux³

et al. 2017

Atlas of Genetics and Cytogenetics in Oncology and Haematology

View full text Add to dashboard Cite

show abstract

“…Another study also revealed reduced expression of breast cancer samples [81]. Down-regulation of ING1 mRNA has also been demonstrated in various other cancer types, including lymphoid malignancies, gastric tumors, brain tumors, lung cancer, ovarian cancer and esophagogastric carcinomas, though no comprehensive clinical correlation was performed [9,10,15,16,[82][83][84][85][86][87][88][89][90]. Uncommon missense mutations and reduced protein expression of ING1 have also been detected in esophageal carcinomas [91], and colon cancer cell lines [83] while no mutation was detected in leukemia [84,92], oral cancers [93] and lymphoid malignancies [82].…”

Section: Disorders Of Ing Family Genes In Human Tumorsmentioning

confidence: 99%