Infusion solutions of gelatin derivates

Adukauskienė, Dalia; Mažeikienė, Sandra; Veikutienė, Audronė; Rimaitis, Kęstutis

doi:10.3390/medicina45010011

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…When treating major hemorrhage, firstly, the volume of lost blood should be estimated and only then the red cells transfused. The goal of maintaining adequate tissue perfusion is normovolemia; therefore, one of the main principals treating acute bleeding is to restore circulating blood volume by fluids, but not by red cell transfusion (2,4,9,18,21).…”

Section: When Should Red Cells Be Transfused?mentioning

confidence: 99%

“…During massive blood loss, firstly, hypovolemia should be managed by crystalloids and colloids infusions as well as tissue hypoxia avoided by donor erythrocytes. This leads to increased coagulopathy risk due to dilution of coagulation factors (21). FFP should be added, in case of massive hemorrhage, when prothrombin time or activated partial thromboplastin time is prolonged for ≥1.5 times (31).…”

Section: Massive Hemorrhagementioning

confidence: 99%

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The usage of blood components in obstetrics

Adukauskienė¹,

Veikutienė²,

Adukauskaitė³

et al. 2010

Medicina

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Major obstetric hemorrhage remains the leading cause of maternal morbidity and mortality worldwide. Even though blood transfusion may be a life-saving procedure, an inappropriate usage of blood products in obstetric emergencies especially in cases of massive bleeding is associated with increased morbidity and risk of death. Thorough knowledge of the etiology, pathophysiology, and optimal therapeutic options of major obstetric hemorrhage may help to avoid lethal outcomes. There are evidence-based data about some risks related with transfusion of blood components: acute or delayed hemolytic, febrile, allergic reactions, transfusion-related acute lung injury, negative immunomodulative effect, transmission of infectious diseases, dissemination of cancer. This is why the indications for allogeneic blood transfusion are restricted, and new safer methods are being discovered to decrease the requirement for it. Red cell alloimmunization may develop in pregnancy; therefore, all pregnant women should pass screening for irregular antibodies. Antierythrocytic irregular antibodies may occur due to previous pregnancies or allogeneic red blood cell transfusions, and it is important for blood cross-matching in the future. Under certain circumstances, such as complicated maternal history, severe coagulation abnormalities, severe anemia, the preparation of cross-matched blood is necessary. There is evidence of very significant variation in the use of blood products (red cells, platelets, fresh frozen plasma, or cryoprecipitate) among clinicians in various medical institutions, and sometimes indications for transfusion are not correctly motivated. The transfusion of each single blood product must be performed only in case of evaluation of expected effect. The need for blood products and for their combination is necessary to estimate for each patient individually in case of obstetric emergencies either. Indications for transfusion of blood components in obstetrics are presented in order to improve the skills of doctors and to optimize therapeutic options in obstetric emergencies.

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Section: When Should Red Cells Be Transfused?mentioning

confidence: 99%

Section: Massive Hemorrhagementioning

confidence: 99%

The usage of blood components in obstetrics

Adukauskienė¹,

Veikutienė²,

Adukauskaitė³

et al. 2010

Medicina

Self Cite

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show abstract

“…Выводятся растворы желатина через выделительную систему в неизменённом виде. Растворы желатина, в отличие от других коллоидов, не изменяют коагуляцию, поэтому безопасны в случае кровоизлияния и тромбоцитопении [52]. Добавление желатина к альгинатному гидрогелю улучшает механические характеристики последнего, увеличивает время гелеобразования, коэффициент набухания, скорость деградации, а также однородность размеров пор [53].…”

Section: Introductionunclassified

Natural components as the structure of hydrogels for cellular therapy and tissue engineering

Dremina,

Trukhan,

Shurygina

2023

Acta biomedica scientifica

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Hydrogels are a class of dimensional hydrophylic polymer networks capable of absorbing and retaining large amounts of water. Natural and synthetic components can serve as a material for the hydrogel production. Hydrogels have unique physico-chemical properties, which are determined by the material composition and concentration, its density, crosslinking methods, and production approaches. This review article describes natural materials used for the production of hydrogels having different properties. The natural components of hydrogels are collagen, elastin, gelatin, chitosan, dextran, hyaluronic acid, alginate, silk fibroin and glycosaminoglycans. These components are considered biodegradable and biocompatible, since they do not have a toxic effect on tissues. Natural materials provide good cell adhesion, the spread of bioactive signals as well as they affect the behavior of cells in vitro and in vivo. To obtain hydrogels, physical and chemical methods of crosslinking are used, which determine the properties of the final product. Also, hydrogels can be further modified by various active molecules, growth factors that increase their biological functionality. To date, hydrogels made of natural materials are widely used in ophthalmology, neurosurgery, in the treatment of skin wounds, in various cardiovascular pathologies, in restoring the volume of circulating blood, some cartilage defects, targeted delivery of pharmacological drugs, active molecules, etc. Thus, hydrogels produced from natural components are an extremely promising material for cellular technologies and tissue engineering.

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