Infusion of a lipid emulsion to treat lidocaine intoxication in a cat

O'Brien, Taylor Q.; Clark‐Price, Stuart C.; Evans, Erika E.; Fazio, Renata Di; McMichael, Maureen

doi:10.2460/javma.237.12.1455

Cited by 62 publications

(54 citation statements)

References 25 publications

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“…Bolus doses of up to 7 ml/kg are also recommended if there is no improvement with this regimen (Fernandez and others 2011). Similar doses have been used in the small number of feline cases reported (O'Brien and others 2010, Pritchard 2010, Haworth and Smart 2012). In a few human case reports, recurrence of toxicity has been reported following cessation of lipid administration (Marwick and others 2009, McAllister and others 2012), hence the recommendation for a bolus dose and then an infusion.…”

Section: Discussionmentioning

confidence: 96%

Lipid infusion in the management of poisoning: a report of 6 canine cases

Bates¹,

Chatterton²,

Robbins³

et al. 2013

Vet Record Case Reports

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Intravenous administration of lipid is a relatively new treatment in the management of toxicity from lipophilic compounds. It is used in human medicine in the treatment of toxicity from lipophilic local anaesthetics and cardiotoxic drugs and can result in dramatic improvement in clinical status. We present six cases of poisoning in dogs successfully treated with lipid infusion after ingestion of ivermectin (3), moxidectin (2) and baclofen (1). The dogs ranged in age from eight weeks to 14 years, and weighed 4–30 kg. Intravenous lipid therapy was started between six and eight hours and 22 hours after ingestion, and all the dogs responded well. In four dogs, there was clinical improvement within one hour; one had improved within two hours and the other within 4.5 hours of lipid administration. The only adverse effect of lipid infusion reported was mild swelling and pain after extravasation in one case which resolved with conservative management. All the dogs were discharged within 24–52 hours after exposure (7–46 hours after the start of lipid administration), and none developed any apparent sequelae.

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Section: Discussionmentioning

confidence: 96%

Lipid infusion in the management of poisoning: a report of 6 canine cases

Bates¹,

Chatterton²,

Robbins³

et al. 2013

Vet Record Case Reports

View full text Add to dashboard Cite

show abstract

“…The use of intravenous lipid emulsion (ILE) has become popular in recent years as an antidote in cases of lipophilic human and veterinary drug toxicosis (Crandell and Weinberg, 2009;O'Brient et al, 2010;Clarke et al, 2011;Haworth and Smart, 2012;Bates et al, 2013;Maton et al, 2013) and has been used to treat ibuprofen toxicity in a dog (Bolfer et al, 2014). The benefits of ILE therapy are thought to be related to improvements in cardiac function and a 'lipid sink' effect, which relies on the formation of a lipid compartment that traps lipophilic drugs (Fernandez et al, 2011).…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Poisoning of dogs and cats by drugs intended for human use

Cortinovis

Pizzo

Caloni

2015

The Veterinary Journal

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“…75 The use of intravenous lipid therapy to treat macrocyclic lactone toxicosis has not been reported in feline patients, but lipid therapy has been used to successfully treat lidocaine toxicosis in a cat. 76 …”

Section: Treatmentmentioning

confidence: 99%