Infusion-line pressure as a real-time monitor of convection-enhanced delivery in pre-clinical models

Lam, Miu Fei; Foo, Stacy; Thomas, Meghan; Lind, Christopher R. P.

doi:10.1016/j.jneumeth.2013.09.019

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…This can be accomplished in a similar method presented by Orozco et al 43,44 It should also be noted that the model presented here utilizes material properties based on agarose gel and indigo carmine dye in order to validate the model with experimental results conducted in agarose. However, despite its common use as a surrogate to brain tissue, 23,25,26,[55][56][57][58][59] the homogeneous nature of agarose cannot replicate the true heterogeneous and non-isotropic features of brain tissue including blood vessels and ventricles which are known to distort the dispersal volume shape. 60…”

Section: Discussionmentioning

confidence: 99%

Convection‐enhanced delivery with controlled catheter movement: A parametric finite element analysis

Mehta

Rausch

Rylander

2022

Numer Methods Biomed Eng

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Convection‐enhanced delivery (CED) is an investigational method for delivering therapeutics directly to the brain for the treatment of glioblastoma. However, it has not become a common clinical therapy due to an inability of CED treatments to deliver therapeutics in a large enough tissue volume to fully saturate the target region. We have recently shown that the combination of controlled catheter movement and constant pressure infusions can be used to significantly increase volume dispersed (Vd) in an agarose gel brain tissue phantom. In the present study, we develop a computational model to predict Vd achieved by various retraction rates with both constant pressure and constant flow rate infusions. An increase in Vd is achieved with any movement rate, but increase in Vd between successive movement rates drops off at rates above 0.3–0.35 mm/min. Finally, we found that infusions with retraction result in a more even distribution in concentration level compared to the stationary catheter, suggesting a potential increased ability for moving catheters to have a therapeutic impact regardless of the required therapeutic concentration level.

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