Infrequently Performed Studies in Nuclear Medicine: Part 2

MacDonald, Alison; Burrell, Steven

doi:10.2967/jnmt.108.057851

Cited by 28 publications

(9 citation statements)

References 23 publications

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“…The scans were performed on a triple-head SPECT camera (Irix Philips) at the University Hospital Bonn and on a dual-head SPECT camera (Siemens E-Cam) at the University Hospital Muenster. The scintigraphic procedure has been described in detail elsewhere [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Early side effects and first results of radioligand therapy with 177Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: a two-centre study

et al. 2015

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BackgroundRadioligand therapy (RLT) with 177Lu-DKFZ-617 PSMA (Lu-PSMA) (prostate-specific membrane antigen) is a novel targeted therapy of metastatic prostate cancer. We analysed retrospectively the early side effects and the response rate in the first patients, who received a therapy with Lu-PSMA in our departments.MethodsRLT was performed in ten hormone- and/or chemo-refractory patients with distant metastases and progressive disease (mean age 73.5 years). 68Ga-PSMA HBED-CC PET/CT was performed in all patients prior to RLT. The median PSA level prior to the therapy was 298.5 ng/ml (range 5–853 ng/ml). All patients received CBC, renal and liver function tests the day before and 2 days after application (mean administered activity 5.6 GBq, range 4.1–6.1 GBq), followed by further tests every 2 weeks. All patients were contacted by telephone every week regarding side effects or any positive and negative changes.ResultsEight weeks after the therapy, seven patients (70 %) experienced a PSA decline, of whom six experienced more than 30 % and five more than 50 %. Three patients showed a progressive disease according to the PSA increase. No patient experienced any side effects immediately after injection of Lu-PSMA. Relevant hematotoxicity (grade 3 or 4) occurred 7 weeks after the administration in just one patient. The same patient showed a leucopenia grade 2. Two patients showed a disturbance of only 1 hematologic cell line, whereas one patient showed a reduction of grades 1 and 2 in leucocytes and thrombocytes, respectively. Six patients did not show any hematotoxicity during the 8 weeks after therapy. There was no relevant nephrotoxicity (grade 3 or 4).ConclusionsOur initial results indicate that RLT with Lu-PSMA is safe and seems to have low early side-effect profile. A relevant PSA decline was detected in 70 % of patients.

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Section: Methodsmentioning

confidence: 99%

Early side effects and first results of radioligand therapy with 177Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: a two-centre study

et al. 2015

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“…In the setting of suspected biliary leak, a variety of imaging modalities, including ultrasound, CT, MRI and endoscopic retrograde cholangiopancreatography (ERCP) can be used [3,[19][20][21][22][23]. Although one could argue that ERCP provides a chance for correcting the underlying abnormality, this is only the case for a limited set of leak locations.…”

Section: Cholescintigraphy (Hida Scan)mentioning

confidence: 99%

“…111-185 MBq of the tracer is administered intravenously and dynamic images are acquired over at least 60 min [3,[19][20][21][22][23]. Dynamic acquisition can be continued as required.…”

Section: Techniquementioning

confidence: 99%

Nuclear medicine and the emergency department patient: an illustrative case-based approach

et al. 2014

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Radiologists are familiar with the use of radiographs, computed tomography, magnetic resonance imaging and ultrasound in the acute clinical setting. However, there are some specific clinical scenarios which may be found in nuclear medicine imaging problem-solving tools. These clinical scenarios and imaging techniques are less frequent, and the referring clinician from the emergency department may not consider these alternatives. It is important for the radiologist to be aware of these techniques to be able to guide the clinician to use those tools, which may result in optimal patient care. In this article, we will discuss those nuclear medicine studies which have application in the setting of an emergency radiology practice.

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“…Clinical Indications in the Acute Care Setting.-Scintigraphic assessment of CSF shunt patency is typically performed in the acute care setting when there are clinical reasons for suspecting that the shunt is malfunctioning (43,44). Initial clinical manifestations may be relatively nonspecific and may include headache, lethargy, and difficulty concentrating.…”

Section: Csf Shunt Scintigraphymentioning

confidence: 99%

Nuclear Medicine in the Acute Clinical Setting: Indications, Imaging Findings, and Potential Pitfalls

Uliel

Mellnick²,

Menias³

et al. 2013

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Nuclear medicine imaging provides valuable functional information that complements information obtained with anatomic imaging techniques in the evaluation of patients with specific acute clinical manifestations. Nuclear medicine studies are most often used in conjunction with other imaging modalities and as a problem-solving tool. Under certain circumstances a nuclear medicine study may be indicated as the first-line imaging modality, as in the case of renal scintigraphy for transplant dysfunction in the early postoperative period. Nuclear imaging may be preferred when a conventional first-line study is contraindicated or when it is important to minimize radiation exposure. The portability of nuclear imaging offers particular advantages for the evaluation of critically ill patients whose clinical condition is unstable and who cannot be safely transported out of the intensive care unit. The ability to visualize physiologic and pathophysiologic processes over relatively long time periods without adding to the patient's radiation exposure contributes to the high diagnostic sensitivity of several types of nuclear medicine studies. Viewing the acquired images in the cine mode adds to the value of these studies for diagnosing and characterizing dynamic abnormalities such as intermittent internal bleeding and bile or urine leakage. In this pictorial review, the spectrum of nuclear medicine studies commonly performed in the acute care setting is reviewed according to body systems and organs, with detailed descriptions of the indications, technical considerations, findings, and potential pitfalls of each type of study. Supplemental material available at http://radiographics.rsna.org/lookup/suppl/doi:10.1148/rg.332125098/-/DC1.

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Infrequently Performed Studies in Nuclear Medicine: Part 2

Cited by 28 publications

References 23 publications

Early side effects and first results of radioligand therapy with 177Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: a two-centre study

Early side effects and first results of radioligand therapy with 177Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: a two-centre study

Nuclear medicine and the emergency department patient: an illustrative case-based approach

Nuclear Medicine in the Acute Clinical Setting: Indications, Imaging Findings, and Potential Pitfalls

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