With the increasing demand for sustainability, the use of cycling as an efficient active mode of transportation is being encouraged. However, the vulnerability of cyclists to severe injuries in crashes can discourage road users from cycling. Therefore, the study of the factors that affect the safety of cyclists is important. This paper describes an investigation of the relationship between cyclist–motorist crashes and various traffic zone characteristics in Vancouver, British Columbia, Canada. The goal was to assess the impacts of socioeconomics, land use, the built environment, and the road facility on cyclist safety through the use of macrolevel collision prediction models. The models were developed by generalized linear regression and full Bayesian techniques. An actual bike exposure indicator (the number of bike kilometers traveled) and the number of vehicle kilometers traveled were used as exposure variables in the models. The safety models showed that cyclist–motorist crashes were nonlinearly associated with an increase in bike, vehicle, and transit traffic as well as socioeconomic variables (i.e., population, employment, and household densities), variables related to the built environment (transit stop, traffic signal, and light pole densities), commercial area density, and the proportion if arterial–collector roads. The models revealed, however, a decline in cyclist–motorist crashes in association with an increase in the proportions of local roads and off-street bike links and an increase in recreational and residential area densities. The spatial effects were accounted for in the full Bayes models and were found to be significant; such a finding implies the importance of consideration of the spatial correlation in the development of macrolevel cyclist safety models.