Computer simulation of infrared images is a key step in the simulation of infrared imaging guidance system, and it plays an important role in the research, inspection and evaluation of missile guidance system. Simulation technology of infrared scene based on the OGRE (Object-Oriented Graphics Rendering Engine) is studied in this paper, the real-time infrared scene images of the typical ground target are simulated, and the comparison and analysis of the simulated infrared images and the real infrared images in visual effect and similarity of the gray histogram is made. The results show that the infrared scene simulation framework proposed based on OGRE is feasible and could meet the actual requirement of simulation.