Infrared spectroscopy using attenuated total reflection

Abstract

An ATR method is given for the examination of pharmaceuticals in the solid state as a layer of crystals on adhesive tape. Representative spectra are chosen to compare with, and to indicate advantages over, disc and mull techniques. Application of the method to pharmaceutical formulations is illustrated by the direct spectral identification of amodiaquine hydrochloride in tablet formulation.

Direct determination of niflumic acid in a pharmaceutical gel by ATR/FTIR spectroscopy and PLS calibration

“…The attenuated total reflectance/Fourier transform infrared spectroscopy (ATR/FTIR), originally developed by Fahrenfort [9], was suggested as a sensible technique to analyse pharmaceutical formulations such as solids, semi-solids and liquids [10,11]. However, very limited applications have been reported for quantification of drugs [12][13][14][15][16] although ATR is a method, which simplifies sample handling, avoids the use of organic solvents and thus saves time and chemical reagents.…”