Infrared solvent shifts and molecular interactions. Part IX. P–H and PO dipoles and the hydrogen-bonding ability of the P–H group

David, J. G.; Hallam, H. E.

doi:10.1039/j19660001103

Cited by 19 publications

(5 citation statements)

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“…Thea ctivity of loaded enzyme was evaluated based on the ability of CPO to catalyze the conversion of monochlorodimedon (MCD) to dichlorodimedon (DCD). [14] As shown in Figure 2a,according to the slopes in 30 softhe kinetic curves of the ultraviolet (UV) absorption spectrum, the loaded CPO had 87.5 %o ft he activity compared with the free CPO,a nd it could still maintained 79.6 %o ft he initial activity after 14 days.E ven after incubation at 45 8 8Cfor 10 min, the loaded CPO still exhibited 75.7 %o ft he activity (Supporting Information, Figure S3a), indicating the good catalytic capability of the MNP-CPO@-Nanogels.A dditionally,t he hydrodynamic diameter of the MNP-CPO@Nanogels remained stable at approximately 180 nm and there is no significant release of CPO from the gel during the two-week observation period (Supporting Information, Figures S3b,S4), suggesting the desirable structure stability the MNP-CPO@Nanogels.A st he precondition of magnetocaloric-enzymatic tandem therapy (METT), the magnetocaloric effect of MNP-CPO@Nanogels and the enzymatic generation of 1 O 2 are pivotal and were first validated separately.M NP-CPO@Nanogels (Fe: 200 mgmL À1 )w ere shaped into the letters M, E, T, and Ton ag lass sheet and exposed to the alternating magnetic field (375 kHz, 12 kA m À1 ,Hffactor 4.5 10 9 Am À1 s À1 ). As shown in Figure 2b,t he temperature of the letters increased from 25 8 8Ct o4 5 8 8C, suggesting that spatial control of magnetocaloric-induced thermal stimulus could be achieved.…”

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 96%

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A Neutrophil‐Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy

Zhang,

Wu,

Wang

et al. 2020

Angew Chem Int Ed

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Neutrophils can responsively release reactive oxygen species (ROS) to actively combat infections by exogenous stimulus and cascade enzyme catalyzed bio‐oxidation. A supramolecular nanogel is now used as an artificial neutrophil by enzymatic interfacial self‐assembly of peptides (Fmoc‐Tyr(H2PO3)‐OH) with magnetic nanoparticles (MNPs) and electrostatic loading of chloroperoxidase (CPO). The MNPs within the nanogel can elevate H2O2 levels in cancer cells under programmed alternating magnetic field (AMF) similar to the neutrophil activator, and the loaded CPO within protective peptides nanolayer converts the H2O2 into singlet oxygen (1O2) in a sustained manner for neutrophil‐inspired tumor therapy. As a proof of concept study, both the H2O2 and 1O2 in cancer cells increase stepwise under a programmed alternating magnetic field. An active enzyme dynamic therapy by magnetically stimulated oxygen stress and sustained enzyme bio‐oxidation is thus shown with studies on both cells and animals.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 96%

A Neutrophil‐Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy

Zhang,

Wu,

Wang

et al. 2020

Angew Chem Int Ed

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“…An account of the stereochemistry of the parent thio-aldoximes has appeared. 19 No further chemical details will be included here.…”

Section: Introductionmentioning

confidence: 99%

Insecticidal activity of some oxime carbamates

Felton¹

1968

J. Sci. Food Agric.

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The insecticidal activity of representatives of a new group, the aldoxime carbamates, has been assessed and compared with that of known carbamate insecticides. Structure/activity relations have first been studied in terms of overall insecticidal activity and ability to inhibit housefly head acetylcholinesterase. Within the aldoxime carbamates, the thio-series are particularly active against caterpillars and the oxy-series against the housefly. Compounds of this group can exist in two geometrical forms, and of these the syn-configuration has been shown to be the more active against the enzyme and against whole insects. Systematic variation of the alkyl substituents has revealed that changes that increase pI50 do not necessarily give higher insecticidal activity. Two further factors, metabolism (inferred from tests with synergists) and partition co-efficient (as measured by Rm value) have therefore been considered. Certain anomalies of pk.0 and toxicity can be explained on the basis of the degree to which compounds can be synergised in the whole housefly. In particular, members of the thio-series are more strongly synergised than those of the oxy-series. It also emerges that PI50 and Rm are directly related within a homologous series, but that there is an optimum Rm value for activity against the housefly.

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“…This explains why PIB with higher exo‐olefin contents are usually produced at cryogenic temperatures (−100 to −20°C), although recent developments have allowed the continuous shifting of processing temperatures towards milder temperature ranges (above 0°C) 4,15,20–24 . Particularly, Biddulph et al suggested that modification of the reaction temperature may induce the modification of the reaction mechanism, as lower temperatures promote the preferential propagation of free ions, while higher temperatures favor the propagation by ion‐pairs 25 . On the other hand, novel catalysts have been reported to overcome this characteristic temperature range limitation, such as the ones described by Kühn and co‐workers, where metallocene/borate initiators, especially manganese, copper, or molybdenum complexes, allowed the polymerization to occur between 20 and 60°C 26–28 …”

Section: Introductionmentioning

confidence: 99%

Cationic polymerization of isobutylene by AlCl3 in n‐hexane and toluene at mild temperatures

Bentes,

Mangia,

Vasconcelos

et al. 2023

J of Applied Polymer Sci

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This study aims to find more efficient ways to manufacture highly reactive polyisobutylene (HRPIB) and modified conventional PIB materials (MCPIB) industrially with high vinyl exo‐group contents through cationic polymerization at mild temperatures. The study performed polymerizations using aluminum trichloride (AlCl3) as a catalyst with different nonpolar solvents (hexane and toluene), reaction temperatures (10 and 30°C), and co‐catalysts (water and dibutyl ether [DBE]). At 30°C, toluene can provide vinyl contents above 30 mol%. Particularly, an important synergetic effect was observed between toluene and ether, as corroborated by statistical analyses, resulting in vinyl contents above 50 mol%, while reactions performed in n‐hexane provided maximum vinyl content of 20 mol%. In all cases, number average molar masses ranged from 200 to 1000 Da, which are typical of CPIB and MCPIB materials. Moreover, addition of excess of ether indicated the likely inhibition of reaction rates in presence of high ether concentrations (≥1.18 × 10 −1 mol/L). The obtained results indicated that AlCl3 can be used successfully to manufacture MCPIB products with terminal vinyl contents above 50 mol% at mild temperatures in common nonpolar solvents (n‐hexane and toluene) and in presence of common co‐catalysts (water and DBE) with high rates of reactions.

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Infrared solvent shifts and molecular interactions. Part IX. P–H and PO dipoles and the hydrogen-bonding ability of the P–H group

Cited by 19 publications

References 0 publications

A Neutrophil‐Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy

A Neutrophil‐Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy

Insecticidal activity of some oxime carbamates

Cationic polymerization of isobutylene by AlCl3 in n‐hexane and toluene at mild temperatures

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