Infrared reflectance imaging in age‐related macular degeneration

Ly, Angelica; Nivison‐Smith, Lisa; Assaad, Nagi; Kalloniatis, Michael

doi:10.1111/opo.12283

Cited by 40 publications

(42 citation statements)

References 59 publications

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“…In contrast, GA will appear as a bright patch on the IR image due to reflection off the sclera. 50,51 Key indications: NIR is especially useful for imaging of atrophic lesions (particularly those involving the fovea centre) and reticular pseudodrusen. See Figure 2B.…”

Section: Near Infrared Imaging (Nir)mentioning

confidence: 99%

Optometry Australia's chairside reference for the diagnosis and management of age‐related macular degeneration

Hart

Abbott

et al. 2020

Clinical and Experimental Optometry

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Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in people over the age of 50 years in Australia. Optometry Australia has developed this AMD chairside reference in consultation with a member-based working group comprised of experienced practitioners. It provides an evidence-based approach to current best practice in the diagnosis and management of AMD. Optometrists should be competent in assessing patients with or at risk of developing AMD, so that they are able to provide evidence-based management including appropriate communication, diagnosis and referral when indicated. This AMD chairside reference covers risk factors for the development of AMD or progression to late-stage AMD; the current clinical classification of AMD; common signs and symptoms; optometric assessment including ocular imaging and biomarkers; differential diagnoses; and management of early, intermediate and late AMD. Optometry Australia's chairside reference is intended as a general guide for optometrists, and is not a formal management protocol.

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Section: Near Infrared Imaging (Nir)mentioning

confidence: 99%

Optometry Australia's chairside reference for the diagnosis and management of age‐related macular degeneration

Hart

Abbott

et al. 2020

Clinical and Experimental Optometry

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“…The test data set were allocated to a panel of selected graders (n = 6) who were previously certified for grading Focal, well-defined spots of hyperreflectivity with a distribution in all, areas of the fundus. 9 Focal deformation or thickening located between the basal lamina of the retinal pigment epithelium (RPE) and Bruch's membrane creating irregularities and undulations of <63 lm in diameter or less. 10…”

Section: Image Selectionmentioning

confidence: 99%

“…8 Well-demarcated, bright zones of hyperreflective regions where choroidal vessel profiles are visible. 9 A sharp edged region of increased signal transmission through the RPE/ Bruch's complex, associated with complete loss of the outer nuclear layer, RPE and underlying choriocapillaris. 13…”

Section: Reticular Pseudodrusenmentioning

confidence: 99%

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Confocal infrared imaging with optical coherence tomography provides superior detection of a number of common macular lesions compared to colour fundus photography

Quinn

Chakravarthy

Muldrew

et al. 2018

Ophthalmic Physiologic Optic

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Purpose: To compare diagnostic accuracy of confocal infrared reflectance (IR), with and without optical coherence tomography (OCT), to colour fundus photography (CFP) in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) Study. Methods: Cross-sectional observational study of participants in NICOLA. CFP, IR and IR/OCT of 640 eyes were graded for hard, soft and reticular pseudodrusen; geographic atrophy; choroidal neovascularisation; naevus; epiretinal membrane; and haemorrhages. Test characteristics (sensitivity and specificity) for each imaging modality with respect to each retinal feature were calculated. Results: With CFP as the reference standard, sensitivity of IR by itself ranged from 75% for RPD to 93.5% for hard drusen and specificity was above 90% for all features except hard drusen (71.7%). For IR combined with OCT, sensitivity ranged from 80% for choroidal neovascularisation to 96.5% for hard drusen. When IR alone was the reference standard, CFP sensitivity was high for naevi (97.5%) but reduced markedly for epiretinal membrane (48.5%). When the combination of IR and OCT was the reference standard, sensitivity for CFP was least for epiretinal membrane (31.5%), low for geographic atrophy and reticular pseudodrusen (77.8% and 76.2% respectively) and high for all other lesion types. Conclusion: Our findings support the use of confocal IR with OCT as a screening tool for a variety of features of macular disease in community optometric practice.

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“…The special issue also emphasised fundamental research questions that can be addressed with imaging. These included diurnal changes in ocular tissues, 5 the use of imaging to understand and diagnose retinal disease 3,6,7 and the extent to which the brain changes its structure and function in individuals with macular degeneration or glaucoma. 8,9 In addition, contemporary themes in vision science imaging research were identified by two invited review papers featured within the special issue.…”

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confidence: 99%