Infrared laser-spectroscopic analysis of 14NO and 15NO in human breath

Heinrich, Kurt F. J.; Fritsch, Thomas; Hering, P.; Mürtz, Manfred

doi:10.1007/s00340-009-3423-1

Cited by 36 publications

(37 citation statements)

References 24 publications

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“…Operation principles of CRDS and CEAS systems are described in the Introduction and in our research activities. Cavity leak-out spectroscopy is a cw variant of the CRDS [17]. After optical excitation of the cavity, the laser beam is turned off and the subsequent power decay of the radiation is registered by a photodetector.…”

Section: Selected Experimental Applicationsmentioning

confidence: 99%

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Aspects of the Application of Cavity Enhanced Spectroscopy to Nitrogen Oxides Detection

Wojtas

Mikołajczyk

Bielecki

2013

Sensors

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This article presents design issues of high-sensitive laser absorption spectroscopy systems for nitrogen oxides (NOx) detection. Examples of our systems and their investigation results are also described. The constructed systems use one of the most sensitive methods, cavity enhanced absorption spectroscopy (CEAS). They operate at different wavelength ranges using a blue—violet laser diode (410 nm) as well as quantum cascade lasers (5.27 μm and 4.53 μm). Each of them is configured as a one or two channel measurement device using, e.g., time division multiplexing and averaging. During the testing procedure, the main performance features such as detection limits and measurements uncertainties have been determined. The obtained results are 1 ppb NO2, 75 ppb NO and 45 ppb N2O. For all systems, the uncertainty of concentration measurements does not exceed a value of 13%. Some experiments with explosives are also discussed. A setup equipped with a concentrator of explosives vapours was used. The detection method is based either on the reaction of the sensors to the nitrogen oxides directly emitted by the explosives or on the reaction to the nitrogen oxides produced during thermal decomposition of explosive vapours. For TNT, PETN, RDX and HMX a detection limit better than 1 ng has been achieved.

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Section: Selected Experimental Applicationsmentioning

confidence: 99%

“…The decay time of each leak-out signal is determined by means of a fast exponential fitting algorithm. In the setup operated at the wavelength of 5.33 μm, a detection limit for NO in the ppt range was obtained [17]. …”

Section: Selected Experimental Applicationsmentioning

confidence: 99%

Aspects of the Application of Cavity Enhanced Spectroscopy to Nitrogen Oxides Detection

Wojtas

Mikołajczyk

Bielecki

2013

Sensors

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“…Their power reaches tens of milliwatts. These lasers [100] are still expensive sources of radiation. However, analysing the progress in optoelectronic technology one can expect a significant reduction of their prices within the forthcoming years [58].…”

Section: Discussionmentioning

confidence: 99%

Ultrasensitive laser spectroscopy for breath analysis

Wojtas

Bielecki

Stacewicz

et al. 2012

Opto-Electronics Review

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At present there are many reasons for seeking new methods and technologies that aim to develop new and more perfect sensors for different chemical compounds. However, the main reasons are safety ensuring and health care. In the paper, recent advances in the human breath analysis by the use of different techniques are presented. We have selected non-invasive ones ensuring detection of pathogenic changes at a molecular level. The presence of certain molecules in the human breath is used as an indicator of a specific disease. Thus, the analysis of the human breath is very useful for health monitoring. We have shown some examples of diseases’ biomarkers and various methods capable of detecting them. Described methods have been divided into non-optical and optical methods. The former ones are the following: gas chromatography, flame ionization detection, mass spectrometry, ion mobility spectrometry, proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry. In recent twenty years, the optical methods have become more popular, especially the laser techniques. They have a great potential for detection and monitoring of the components in the gas phase. These methods are characterized by high sensitivity and good selectivity. The spectroscopic sensors provide the opportunity to detect specific gases and to measure their concentration either in a sampling place or a remote one. Multipass spectroscopy, cavity ring-down spectroscopy, and photo-acoustic spectroscopy were characterised in the paper as well.

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“…Using this spectral range nitric oxide has been already detected with sensitivity up to the ppb levels. The techniques as MUPASS -WMS [46][47][48], ICOS [49,50], and CALOS [51] were demonstrated. Our experiment with nitric oxide detection in the N 2 was performed using CEAS technique.…”

Section: Nitric Oxide (No)mentioning

confidence: 99%