Infrared identification of pharmaceutically important steroids with particular reference to the occurrence of polymorphism

Abstract

The infrared absorption spectra of steroids, when compared with the spectra of Authentic Specimens, provide a simple and complete means of identification, provided that the effects of polymorphism are precluded. Of 35 substances examined, 16 showed no evidence .of polymorphism and a further twelve were sufficiently soluble to be examrned In solution. Specific solvent treatments, details of which are given, may be necessary with the remaining seven substances if the spectra of the sample and of the Authentic Specimen are not identical when first examined.

Infrared identification of barbiturates with particular reference to the occurrence of polymorphism

“…It is a necessary condition for this comparison that the two specimens should be in the same physical state. Where it is possible to record the spectra of the substances in solution this presents no difficulty, but if solid-state spectra are used polymorphism may be encountered, and it may then be necessary to specify treatments for individual substances to ensure the production of consistent spectra, as in such compounds as steroids (Mesley & Johnson, 1965) and sulphonamides (Mesley & Houghton, 1967).…”

“…Samples were prepared for infrared examination both as mulls in liquid paraffin (Nujol) and as pressed potassium bromide discs using the technique previously described (Mesley & Johnson, 1965). Spectra were recorded using Grubb Parsons GS 2 and Perkin-Elmer 237 grating spectrometers.…”

Prednisone raw material characterization and formulation development

“…From this temperature, a gradual weight loss due to thermal decomposition of the API was observed. This result excludes the possibility of said samples when treating the monohydrate form or solvate with chloroform, as reported in the literature, because the samples studied exhibited no mass loss until the beginning of their thermal decomposition (KuhnertBramdstätter, Gasser, 1971;Mesley, Johnson, 1965).…”

Synthesis, Antibacterial and Lipoxygenase Inhibition Studies of <i>N</i>-(Alkyl/aralkyl)-<i>N</i>-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides

“…Results are presented as mean ± standard error of mean. /aralkyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl) N-(alkyl/aralkyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides (5a-e) Chemistry N-2,3-Dihydro-1,4-benzodioxine-6-amine (1) was reacted with 4-methylbenzenesulfonyl chloride (2) in the presence of 10% Na 2 CO 3 under dynamic pH control at 9-10 under stirring for 2-3 hours at room temperature to achieve N-(2,3-dihydro-1,4benzodioxin-6-yl)-4-methylbenzenesulfonamide (3). Further, alkyl/aralkylation of the parent compound 3 was done utilizing different alkyl/aralkyl halides (4a-e) in DMF as a polar aprotic solvent and LiH as the base to yield the new target compounds (5a-e).…”

“…1 Sulfa drugs do not possess any odor and they are mostly white in color or have slightly colored solids, soluble in water and exhibits more than two polymorphic forms. 2,3,4 Sulfonamides are capable of inhibiting bacterial growth, they also contest against p-aminobenzoic acid for dihydropteroatesynthetase enzyme, which is necessary for the biogenesis of folic acid (required for the growth of cell) by bacteria. 5,6 Sulfonamides possess antimicrobial activity against Gram-positive and Gramnegative bacteria and act as carbonic anhydrase inhibitors.…”