Infrared and Raman Spectroscopy of Biological Materials

Gremlich, Hans‐Ulrich; Yan, Bing

doi:10.1201/b16936

Cited by 180 publications

(156 citation statements)

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“…The results show that the SC is a nonuniform membrane, characterized by gradients of the water and lipid content. Regarding non-invasive methods reported for monitoring water content in the skin in vivo, instruments based on transepidermal water loss properties [57], dielectric properties such as conductance and capacitance [58] and spectroscopic techniques, such as near-infrared spectroscopy [38], and Confocal Raman microscopy [40,59] have been used. Even though conductance and capacitance based hydration measurements are cheap and portable, these measurements give only relative water content, not absolute values as in the case of Confocal Raman.…”

Section: Discussionmentioning

confidence: 99%

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Potential of short-wave infrared spectroscopy for quantitative depth profiling of stratum corneum lipids and water in dermatology

Ezerskaia¹,

Uzunbajakava²,

Puppels³

et al. 2018

Biomed. Opt. Express

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Abstract:We demonstrate the feasibility of short wave infrared (SWIR) spectroscopy combined with tape stripping for depth profiling of lipids and water in the stratum corneum of human skin. The proposed spectroscopic technique relies on differential detection at three wavelengths of 1720, 1750, and 1770 nm, with varying ratio of the lipid-to-water absorption coefficient and an 'isosbestic point'. Comparison of the data acquired using SWIR spectroscopy with that obtained by a gold standard for non-invasive quantitative molecularspecific skin measurements, namely confocal Raman spectroscopy (CRS), revealed specificity of the proposed modality for water and lipid quantification. At the same time, we provide evidence showing aberrant sensitivity of Corneometer hydration read-outs to the presence of skin surface lipids, and a lack of sensitivity of the Sebumeter when attempting to measure the lipids of the cornified lipid envelope and intracellular lipid layers. We conclude that a spectroscopic SWIR-based spectroscopic method combined with tape stripping has the potential for depth profiling of the stratum corneum water and lipids, due to superior measurement sensitivity and specificity compared to the Corneometer and Sebumeter. References and links1. D. J. Tobin, "Introduction to skin aging," J. Tissue Viability 26(1), 37-46 (2017). 2. P. C. Arck, A. Slominski, T. C. Theoharides, E. M. Peters, and R. Paus, "Neuroimmunology of stress: skin takes center stage," J. Invest. Dermatol. 126(8), 1697-1704 (2006). 3. K. R. Feingold and P. M. Elias, "Role of lipids in the formation and maintenance of the cutaneous permeability barrier," Biochim. Biophys. Acta 1841(3), 280-294 (2014). 4. D. J. Tobin, "Biochemistry of human skin--our brain on the outside," Chem. Soc. Rev. 35(1), 52-67 (2006). 5. M. Akiyama, "Corneocyte lipid envelope (CLE), the key structure for skin barrier function and ichthyosis pathogenesis," J. Dermatol. Sci. 88(1), 3-9 (2017). 6. K. C. Madison, "Barrier function of the skin: "la raison d'être" of the epidermis," J. Invest. Dermatol. 121(2), 231-241 (2003). 7. D. J. Tobin, "Introduction to skin aging," J. Tissue Viability 26(1), 37-46 (2017 75-83 (2015). 13. R. J. Richters, N. E. Uzunbajakava, D. Falcone, J. C. Hendriks, E. J. Jaspers, P. C. van de Kerkhof, and P. E. van Erp, "Clinical, biophysical and immunohistochemical analysis of skin reactions to acute skin barrier disruptiona comparative trial between participants with sensitive skin and those with nonsensitive skin," Br. J. Dermatol. 174(5), 1126-1133 (2016). 14. M. Akiyama, "Corneocyte lipid envelope (CLE), the key structure for skin barrier function and ichthyosis pathogenesis," J. Dermatol. Sci. 88(1), 3-9 (2017). 15. M. Sullivan, N.B. Silverberg, "Current and emerging concepts in atopic dermatitis pathogenesis," Clin, Dermatol.35 (

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Section: Discussionmentioning

confidence: 99%

“…Confocal Raman microspectroscopy has been successfully used for several dermatological applications. With further developments for reducing the cost, CRS has the potential to enter the mainstream of clinical and dermatological practice with even wider range of applications [39][40][41][42].…”

Section: State Of the Art Methods For Quantification Of Skin Lipids Amentioning

confidence: 99%

Potential of short-wave infrared spectroscopy for quantitative depth profiling of stratum corneum lipids and water in dermatology

Ezerskaia¹,

Uzunbajakava²,

Puppels³

et al. 2018

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…A range of methods exist for IR imaging such as Photoacoustic microscopy, synchrotron infrared microspectrometry, however the spatial resolution of these approaches is limited by diffraction to /2 [14][15][16][17][37][38][39][40]. Resulting in the lateral IR image resolution limited to the micron lengthscale.…”

Section: Discussionmentioning

confidence: 99%

Nanoscale optical imaging by atomic force infrared microscopy

Rice

2010

Nanoscale

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This review outlines an emerging nano-imaging method referred to as Atomic Force Microscopy Infrared Microscopy that enables IR imaging with lateral nanoscale resolution based on combining AFM and optical methodologies. Atomic Force Microscopy Infrared Microscopy enables imaging with nanoscale resolution and enables simultaneously AFM topography imaging. This review outlines the methodology and its application in imaging both biological and functional materials, including an outline of where this emerging method has been applied to image cellular systems in aqueous environments opening up the way for live cell imaging.

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“…FT-IR spectroscopy is a powerful tool for providing conformational and structural information [40]. The spectrum of chloropropyl silica shows a conspicuous peak at the wavelength of 700 cm À1 (Fig.…”

Section: Ft-ir Analysismentioning

confidence: 99%

Solid‐phase extraction of liquiritin and glycyrrhizic acid from licorice using ionic liquid‐based silica sorbent

Tian

Row

2009

J of Separation Science

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A new ionic liquid-based silica sorbent was developed by a process involving surface chemical modification of commercial silica using a synthesized ionic liquid. The obtained particles were successfully used as a special sorbent in a solid-phase extraction process to isolate liquiritin and glycyrrhizic acid from licorice. Different washing and elution solvents, such as water, methanol/water (v/v), and pure methanol were evaluated. Ionic liquid-based silica sorbent was compared with traditional C 18 sorbent and it exhibited higher selectivity. Quantitative analysis was carried out by using a C 18 column. Good linearities of two compounds were obtained from 5 Â 10 À4 to 0.2 mg/mL (r 2 40.99) with the relative standard deviations o1.0%. The target compounds in commercial herbal medicines containing licorice were determined, and the bound rates between the target compounds and protein were obtained by this sorbent.

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Infrared and Raman Spectroscopy of Biological Materials

Cited by 180 publications

References 0 publications

Potential of short-wave infrared spectroscopy for quantitative depth profiling of stratum corneum lipids and water in dermatology

Potential of short-wave infrared spectroscopy for quantitative depth profiling of stratum corneum lipids and water in dermatology

Nanoscale optical imaging by atomic force infrared microscopy

Solid‐phase extraction of liquiritin and glycyrrhizic acid from licorice using ionic liquid‐based silica sorbent

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