Infrared and Raman spectral studies of L‐ornithine nitrate

Abstract

FT-IR and FT-Raman spectra of L-ornithine nitrate were recorded and analyzed. The assignments of the fundamental vibrational modes due to COO − , NH 3 + , CH 2 , CH, CN and NO 3 − groups were made. The carboxylic group is found to exist as the COO − ion in the crystal. The formation of N-H· · ·O hydrogen bonds in the crystal contributes considerably to the crystal cohesion. The wavenumbers of several modes of vibrations were shifted from the expected values, indicating extensive intermolecular hydrogen bonding. Some of the forbidden modes of the nitrate group have been observed. The removal of degeneracy of the nitrate anion suggests that the symmetry of the nitrate group has been affected in the crystalline environment.

Phase IIb dose‐ranging study of the oral JAK inhibitor tofacitinib (CP‐690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease‐modifying antirheumatic drugs

“…It is evident that the peak intensity at 3440 cm −1 corresponding to ‐OH group25 significantly decreases after the modification with BOZ functional silane. The characteristic absorptions of the modified nano‐SiO 2 at 2934–2978 cm −1 (stretching vibration of CH 2 ) and at 1457–1489 cm −1 (bending vibration of CH 2 ) are observed, which indicate that the BOZ functional silane has been coupled onto the nano‐SiO 2 surface 26. The characteristic peaks of BOZ at 940 cm −1 and Si‐OH at 955 cm −1 overlap.…”

Vibrational spectral studies of (β‐alanine) β‐alaninium nitrate

“…These assignments are consistent with O-C-O and C-C-O deformation vibrations of L-ornithine nitrate. 18 The hydrogen atom which lies on the center of symmetry links two alanine residue through a strong symmetric O-HÐ Ð ÐO hydrogen bond of length 2.46Å. The stretching vibrations of the OH group in the amino acid can be expected around 3000 cm 1 .…”

A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-l-ornithine causes cancer cell death by inducing a p53-dependent activation of the mitochondrial pathway of apoptosis

“…The IR bands of compound were assigned by comparison with the IR spectra of the free amino acid (N-tert-butoxycarbonyl-L-ornithine) [22,23] [24]. Although a clear line between the two categories cannot be drawn, the observed value of Dm (241 cm À1 ) strongly points to a monodentate coordination of the carboxylate group of the ligand to the tin atom [25].…”