Infraorbital nerve enlargement due to IgG4-related disease

Jayaprakasam, Anuradha; O’Donovan, Dominic G; René, C

doi:10.1038/eye.2014.32

Cited by 3 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One year later, Inoue et al described lesions involving the infraorbital and supraorbital nerves in 5 patients with IgG4-RD [11]. Following these early reports, several articles have stressed the association between IgG4-related orbital disease and ION enlargement [10,13,[15][16][17][25][26][27][28]. We believe that the emphasis on ION enlargement may simply be related to the proximity of these branches to the orbital contents.…”

Section: Discussionmentioning

confidence: 99%

“…In 2011 Katsura et al reported a patient with isolated enlargement of V2 and V3 branches due to an inflammatory process diagnosed as IgG4-RD [9]. Following this report, TGN enlargement, especially of the infraorbital nerve, has been strongly associated with IgG4-RD [10][11][12][13][14][15][16][17][18], Widespread involvement of the TGN is an important feature of IgG4-related disease [19] and less frequently with idiopathic inflammation [20] and lymphoid hyperplasia [16]. Herein we present a new finding of group of patients with orbital disease in whom different TGN divisions were enlarged not only with IgG4-RD, but also with vasculitis and RDD with bilateral perineural enhancement even in unilateral eye disease.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enlargement of Multiple Branches of the Trigeminal Nerve in Non-Neoplastic Orbital Diseases: Review of MR Imaging in 14 Cases

SM¹,

MC²,

Cintra³

et al. 2022

JCMI

View full text Add to dashboard Cite

Background: Head and neck perineural disease is typically associated with cancer, but it can be associated with non-neoplastic conditions, especially IgG4-Related disease. Purpose: We present the MRI findings of trigeminal nerve involvement in 14 patients with 3 different types of non-neoplastic orbital disease. Material and Methods: A retrospective review of MR images of patients with enlargement of distinct TGN divisions who were evaluated in a neuro-ophthalmology clinic and were subsequently proved to have non-neoplastic orbital infiltrative or inflammatory diseases. Three experienced radiologists reviewed the MRI studies looking for extent and characteristics of perineural disease along the pathway of the 3 TGN divisions. Results: MRI demonstrated enhancement of at least one TGN division in 14 patients with bilateral or unilateral orbital infiltrative non-neoplastic conditions (22 orbits). Six patients had IgG4-RD, 3 RDD, and 5 c-ANCA-associated vasculitis. Overall, 13 (92.8%) patients displayed enlargement of V2, 12 (85.7%) of V1 and 7 (50%) of V3. Simultaneous enlargement of V1 and V2 was detected in 11 (78.6%) patients, and all 3 divisions were simultaneously involved in 6 (42.8%). Other radiological findings included abnormal contrast enhancement and soft tissue thickening in the cavernous sinus, Meckel’s cave, and/or the cisternal segment of the trigeminal nerve. Conclusions: Although trigeminal thickening associated with non-malignant orbital infiltration is commonly considered a sign of IgG4-RD, other conditions such as vasculitis and RDD should be considered in the differential diagnosis of these uncommon cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enlargement of Multiple Branches of the Trigeminal Nerve in Non-Neoplastic Orbital Diseases: Review of MR Imaging in 14 Cases

SM¹,

MC²,

Cintra³

et al. 2022

JCMI

View full text Add to dashboard Cite

show abstract

Headache, Facial Pain, and Disorders of Facial Sensation

Ko¹,

Prasad²

2019

Liu, Volpe, and Galetta's Neuro-Ophthalmology

View full text Add to dashboard Cite

Involvement of Multiple Trigeminal Nerve Branches in IgG4-Related Orbital Disease

Elkhamary

Cruz

Zotin

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Purpose: To describe the occurrence of multiple trigeminal nerves (TGNs) enlargement in patients with orbital IgG4-related disease. Methods: Retrospective review of MRI findings and medical records of 6 patients (10 orbits) with orbital IgG4-related disease and enlargement of more than 1 TGN. Orbital biopsies were performed in all cases revealing the typical lymphoplasmacytic infiltrate with significant plasma cell positivity for IgG4 (IgG4+/IgG ratio ≥ 40%). Three experienced neuroradiologists reviewed the MRI sequences using a digital imaging viewer system (Horos, https://horosproject.org/). Results: Bilateral involvement of at least 2 TGNs divisions was detected in all 6 patients. Enlargement of both V1 and V2 nerves was diagnosed in 5 patients, and in 3 cases, all TGN divisions were involved. V2 nerves were the most affected. In this division, all 12 infraorbital nerves were enlarged, followed by lesser palatines (10/83.3%), superior alveolar (10/83.3%), and zygomatic (6/50%). V1 and V3 nerves were less affected albeit 9 (75%) frontal branches (V1), and 50% of the inferior alveolar (V3) nerves were also enlarged. Conclusions: Widespread involvement of the TGN is an important feature of IgG4-related disease.

show abstract

Infraorbital nerve enlargement due to IgG4-related disease

Cited by 3 publications

References 5 publications

Enlargement of Multiple Branches of the Trigeminal Nerve in Non-Neoplastic Orbital Diseases: Review of MR Imaging in 14 Cases

Enlargement of Multiple Branches of the Trigeminal Nerve in Non-Neoplastic Orbital Diseases: Review of MR Imaging in 14 Cases

Headache, Facial Pain, and Disorders of Facial Sensation

Involvement of Multiple Trigeminal Nerve Branches in IgG4-Related Orbital Disease

Contact Info

Product

Resources

About