Infradian and Ultradian Rhythms of Body Temperature Resumption during Hibernation

Diatroptov, M. E.; Rutovskaya, M. V.; Kuznetсova, E. V.; Диатроптова, М. А.; Косырева, А. М.; Джалилова, Д. Ш.; Ponomarenko, E A; Panchelyuga, V. A.; Станкевич, А. И.

doi:10.1007/s10517-019-04693-9

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Ultradian rhythms are often co-expressed with circadian (∼24 h) rhythms, which was first reported by Szymansky when looking at behavioural activity patterns in a range of species ( Szymanski, 1920 ). Since then, ultradian rhythms have been reported in numerous behavioural and physiological processes such as locomotor and feeding behaviour ( Gerkema and van der Leest, 1991 ; van Oort et al, 2007 ; Dowse et al, 2010 ; van Beest et al, 2020 ; Morris et al, 2022 ), body temperature ( Lindsley et al, 1999 ; Diatroptov et al, 2019 ; 2020 ; Thiel et al, 2022 ), glucocorticoid concentration ( Lightman et al, 2008 ; Waite et al, 2012 ; Flynn et al, 2018 ), hormone release ( Van Cauter, 1990 ; Droste et al, 2008 ; Waite et al, 2012 ; Kalafatakis et al, 2018 ), central monoamine release ( Blum et al, 2014 ), gene expression ( Hughes et al, 2009 ; van der Veen and Gerkema, 2017 ; Ballance and Zhu, 2021 ; Scott et al, 2023 ), and cellular metabolism ( Brodsky, 2014 ; Zhu et al, 2017 ; Goh et al, 2019 ; Ballance and Zhu, 2021 ; Yang et al, 2022 ; Asher and Zhu, 2023 ; Psomas et al, 2023 ). Despite these widespread observations of ultradian rhythms, very little is known about their function and the intrinsic mechanisms that drive them.…”

Section: Introductionmentioning

confidence: 99%

Reduced glucose concentration enhances ultradian rhythms in Pdcd5 promoter activity in vitro

Ting,

Psomas,

Skene

et al. 2023

Front. Physiol.

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Intrinsically driven ultradian rhythms in the hourly range are often co-expressed with circadian rhythms in various physiological processes including metabolic processes such as feeding behaviour, gene expression and cellular metabolism. Several behavioural observations show that reduced energy intake or increased energy expenditure leads to a re-balancing of ultradian and circadian timing, favouring ultradian feeding and activity patterns when energy availability is limited. This suggests a close link between ultradian rhythmicity and metabolic homeostasis, but we currently lack models to test this hypothesis at a cellular level. We therefore transduced 3T3-L1 pre-adipocyte cells with a reporter construct that drives a destabilised luciferase via the Pdcd5 promotor, a gene we previously showed to exhibit robust ultradian rhythms in vitro. Ultradian rhythmicity in Pdcd5 promotor driven bioluminescence was observed in >80% of all cultures that were synchronised with dexamethasone, whereas significantly lower numbers exhibited ultradian rhythmicity in non-synchronised cultures (∼11%). Cosine fits to ultradian bioluminescence rhythms in cells cultured and measured in low glucose concentrations (2 mM and 5 mM), exhibited significantly higher amplitudes than all other cultures, and a shorter period (6.9 h vs. 8.2 h, N = 12). Our findings show substantial ultradian rhythmicity in Pdcd5 promotor activity in cells in which the circadian clocks have been synchronised in vitro, which is in line with observations of circadian synchronisation of behavioural ultradian rhythms. Critically, we show that the amplitude of ultradian rhythms is enhanced in low glucose conditions, suggesting that low energy availability enhances ultradian rhythmicity at the cellular level in vitro.

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Section: Introductionmentioning

confidence: 99%

Reduced glucose concentration enhances ultradian rhythms in Pdcd5 promoter activity in vitro

Ting,

Psomas,

Skene

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Infradian about 4-day fluctuations were found in many biological parameters: concentrations of melatonin, glucocorticoid and sex hormones 1 – 6 , motor activity 7 , immune system 8 , 9 , mitotic activity of cells 10 , 11 . Based on the facts that (1) 4-day rhythms are preserved during the removal both of the testes and adrenal glands 12 , and (2) hibernating hedgehogs with reduced hormonal activity had the stable rhythms of spontaneous short-term arousals 13 , it can be argued that the formation of this infradian rhythm is not associated with hormonal regulation. It is interesting that the removal of the pineal gland, which is involved in the formation of circadian rhythms 14 , also does not affect the period and phase of the 4-day rhythm of mitotic activity of the rat esophagus epithelium 7 .…”

Section: Introductionmentioning

confidence: 99%

About 4-day rhythm of proliferative activity of fibroblast-like cell cultures isn’t endogenous and don’t depend from the variations of Earth’s magnetic field

Диатроптова

Косырева

Diatroptov

2022

Sci Rep

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A study of the 4-day rhythm of the proliferative activity of the embryonic fibroblast-like cells in the logarithmic growth phase was carried out. It was shown that in cell cultures obtained on different days from embryos of different ages, the phase of the 4-day rhythm coincides. In vitro the maxima of the proliferative activity were consistent with the minima of the motor activity of mice. Freezing the culture for 2 or 6 days does not cause a shift in the phase of the 4-day rhythm of cell proliferative activity compare with the unfreezing culture. That indicates the existence of an external synchronizer, which determines the 4-day infradian rhythm of the proliferative activity of embryonic cells. Then we daily thawed samples of single L929 culture of mice fibroblast-like cells for 22 and 17 days and researched the dynamics of its proliferative activity. We also showed 4-day rhythm of the simultaneous increase in the number of cells for all thawed samples. Taking into account that deep freezing of a culture leads to the cessation of all life processes, the fact we obtained indicates an exogenous mechanism of the formation of about a 4-day rhythm of the proliferative activity of cell culture. Variations of the Earth's magnetic field could be one of the external synchronizers of the infradian rhythm. We studied the increase in number of L929 cell in conditions of a magnetic permalloy screen and showed that the magnetic shielding no affect the parameters of the infradian rhythm of L929 cell proliferative activity. So further searches of the external synchronizers are need.

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“…Infradian about 4-day uctuations were found in many biological parameters: concentrations of melatonin, glucocorticoid and sex hormones [1][2][3][4][5][6], motor activity [7], immune system [8,9], mitotic activity of cells [10,11]. Based on the facts that 1) 4-day rhythms are preserved during the removal both of the testes and adrenal glands [12], and 2) hibernating hedgehogs with reduced hormonal activity had the stable rhythms of spontaneous short-term arousals [13], it can be argued that the formation of this infradian rhythm is not associated with hormonal regulation. It is interesting that the removal of the pineal gland, which is involved in the formation of circadian rhythms [14], also does not affect the period and phase of the 4-day rhythm of mitotic activity of the rat esophagus epithelium [7].…”

Section: Introductionmentioning

confidence: 99%

About 4-day Rhythm of Proliferative Activity of Fibroblast-like Cell Cultures Depends on the Environmental Factor

Диатроптова

Косырева

Diatroptov

2021

Preprint

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A study of the 4-day rhythm of the proliferative activity of the embryonic fibroblast-like cells in the logarithmic growth phase was carried out. It was shown that in cell cultures obtained on different days from embryos of different ages, the phase of the 4-day rhythm coincides. In vitro the maxima of the proliferative activity were consistent with the minima of the motor activity of mice. Freezing the culture for 2 or 6 days does not cause a shift in the phase of the 4-day rhythm of cell proliferative activity compare with the unfreezing culture. That indicates the existence of an external synchronizer, which determines the 4-day infradian rhythm of the proliferative activity of embryonic cells. Then we daily thawed samples of single L-929 culture of mice fibroblast-like cells for 22 and 17 days and researched the dynamics of its proliferative activity. We also showed 4-day rhythm of the simultaneous increase in the number of cells for all thawed samples. Taking into account that deep freezing of a culture leads to the cessation of all life processes, the fact we obtained indicates an exogenous mechanism of the formation of about a 4-day rhythm of the proliferative activity of cell culture.

show abstract

Infradian and Ultradian Rhythms of Body Temperature Resumption during Hibernation

Cited by 4 publications

References 10 publications

Reduced glucose concentration enhances ultradian rhythms in Pdcd5 promoter activity in vitro

Reduced glucose concentration enhances ultradian rhythms in Pdcd5 promoter activity in vitro

About 4-day rhythm of proliferative activity of fibroblast-like cell cultures isn’t endogenous and don’t depend from the variations of Earth’s magnetic field

About 4-day Rhythm of Proliferative Activity of Fibroblast-like Cell Cultures Depends on the Environmental Factor

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