Infra-Low Frequency Neurofeedback in Depression: Three case studies

Grin-Yatsenko, Vera A.; Othmer, Siegfried; Пономарев, В. А.; Evdokimov, S. A.; Konoplev, Yuri Y.; Kropotov, Juri D.

doi:10.15540/nr.5.1.30

Cited by 24 publications

(21 citation statements)

References 46 publications

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“…Consequently, the increase in the amplitude of the ILF activity found in the present study can be discussed in accordance with the mechanisms of the individual compensatory-adaptive brain-body regulation in response to stress factors [48]. In the present research, we assume that our participants had initial constraints in compensatory-adaptive brain reactions, which lead to the reduced brain tissue metabolic regulation followed by energy deficient state.…”

Section: Discussionsupporting

confidence: 82%

“…The present study shows that ILF training outcomes are associated with an increase in amplitude of ILF. The increase in amplitude and regularity of ILF was previously described and discussed as a sign of improved tissue metabolic activity [48][49][50]. Therefore, the positive trend in ILF characteristics observed in our study may be linked to the increased compensatory mechanisms in the stress regulation systems.…”

Section: Discussionsupporting

confidence: 75%

“…Previously published results discussed the possible involvement of ILF in the modulation of the internal organization of the DMN, which is associated with the brain homeostatic balance and is involved in the autonomic regulation [35,36,51]. These results support the hypothesis of the metabolic stress regulatory mechanisms [48] and raise the question on the role of DMN network in homeostatic balance and metabolic compensation in stress response.…”

Section: Discussionsupporting

confidence: 65%

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Effect of Infra-Low Frequency Neurofeedback on Infra-Slow EEG Fluctuations

Grin-Yatsenko¹,

Пономарев²,

Kara³

et al. 2018

Biofeedback

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Infra-low frequency neurofeedback (ILF NF) has been proposed as an alternative or complementary treatment method. Previous studies have reported a good effect of ILF training on the subjective perception of positive psychological changes after training. Here we study whether the objective physiological parameters reflecting the brain function also change under the influence of ILF NF. Eight participants 21-50 years of age with no history of neurological or psychiatric diseases, but reporting about some physiological or psychological complaints, performed 20 sessions of infra-low frequency neurofeedback training. EEG in visual Go/NoGo test was recorded before the course of Neurofeedback and after its completion. The spectral power of slow EEG oscillations in the post-training recording was compared with the pretraining baseline. Along with remission of the clinical complaints, significant increase of spectral power in 0-0.5 Hz frequency band was observed in all eight participants in the post-training EEG patterns compared to the pretraining EEG, which may be linked to the improvement in the metabolic balance in the brain tissue and increasing efficiency of compensatory mechanisms in the stress regulation systems.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 65%

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Effect of Infra-Low Frequency Neurofeedback on Infra-Slow EEG Fluctuations

Grin-Yatsenko¹,

Пономарев²,

Kara³

et al. 2018

Biofeedback

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“…There are numerous studies that report decreases in depression on the Minnesota Multiphasic Personality Inventory (MMPI) and other measures following NT, typically involving alpha/theta protocols (Cheon, Koo, & Choi, 2016;Grin-Yatsenko et al, 2018;Hammond, 2005;Raymond, Varney, Parkinson, & Gruzelier, 2005;Wang et al, 2016). Scott et al (2005) reported improvements on the MMPI which included the experimental group's changes and exhibited a significant improvement compared with the changes in the control subjects on the Hypochondriasis, Depression, Conversion Hysteria, Schizophrenia, and Social Introversion scales.…”

Section: Depressionmentioning

confidence: 99%

Perspectives on Placebo: The Psychology of Neurofeedback

Thornton¹

2018

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The application of operant conditioning with EEG variables to produce changes in behavior has been gaining increasing interest in research and application areas. However, the methodology has come under scrutiny and criticism for its potential placebo effects. This article will examine those issues from the traditional methodologies of demonstrating effectiveness (control group, sham treatments) as well as examine the possible biochemical and electrophysiological effects of a placebo response. Specifically, the role of endorphins and dopamine and their relationship to the alpha and beta frequency in the placebo response will be examined. The research addressing the diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) correlates of the intervention will be examined.

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“…Grin-Yatsenko et al [128] cite papers by Othmer et al inspired by Sterman SMR training seizure protocol on the one hand and Ayers' for brain traumatic injury with beta-1 upregulation on the other hand. The final edition of the protocol involved 15-18 Hz for the left prefrontal area (Fp1-C3) and 12-15 Hz for the right parietal cortex (C4-Pz).…”

mentioning

confidence: 99%

The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review

Мельников

2021

Neural Plasticity

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This article is aimed at showing the current level of evidence for the usage of biofeedback and neurofeedback to treat depression along with a detailed review of the studies in the field and a discussion of rationale for utilizing each protocol. La Vaque et al. criteria endorsed by the Association for Applied Psychophysiology and Biofeedback and International Society for Neuroregulation & Research were accepted as a means of study evaluation. Heart rate variability (HRV) biofeedback was found to be moderately supportable as a treatment of MDD while outcome measure was a subjective questionnaire like Beck Depression Inventory (level 3/5, “probably efficacious”). Electroencephalographic (EEG) neurofeedback protocols, namely, alpha-theta, alpha, and sensorimotor rhythm upregulation, all qualify for level 2/5, “possibly efficacious.” Frontal alpha asymmetry protocol also received limited evidence of effect in depression (level 2/5, “possibly efficacious”). Finally, the two most influential real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback protocols targeting the amygdala and the frontal cortices both demonstrate some effectiveness, though lack replications (level 2/5, “possibly efficacious”). Thus, neurofeedback specifically targeting depression is moderately supported by existing studies (all fit level 2/5, “possibly efficacious”). The greatest complication preventing certain protocols from reaching higher evidence levels is a relatively high number of uncontrolled studies and an absence of accurate replications arising from the heterogeneity in protocol details, course lengths, measures of improvement, control conditions, and sample characteristics.

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Infra-Low Frequency Neurofeedback in Depression: Three case studies

Cited by 24 publications

References 46 publications

Effect of Infra-Low Frequency Neurofeedback on Infra-Slow EEG Fluctuations

Effect of Infra-Low Frequency Neurofeedback on Infra-Slow EEG Fluctuations

Perspectives on Placebo: The Psychology of Neurofeedback

The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review

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