Informing women with breast cancer about endocrine therapy: effects on knowledge and adherence

Heisig, Sarah R.; Shedden-Mora, Meike C.; Blanckenburg, Pia von; Schuricht, Franziska; Rief, Winfried; Albert, Ute‐Susann; Nestoriuc, Yvonne

doi:10.1002/pon.3611

Cited by 61 publications

(64 citation statements)

References 38 publications

(69 reference statements)

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“…Therefore, it may be essential that the clinicians are aware of signs and symptoms of depression in these women, providing the correct diagnosis, and offering appropriate therapy. This may be of importance in adherence to treatment and the cancer rehabilitation [46]. In this study however, there were no differences in demographic and treatment variables in the two groups of patients.…”

Section: Discussioncontrasting

confidence: 77%

Fatigue, anxiety and depression overrule the role of oncological treatment in predicting self-reported health complaints in women with breast cancer compared to healthy controls

et al. 2016

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Section: Discussioncontrasting

confidence: 77%

Fatigue, anxiety and depression overrule the role of oncological treatment in predicting self-reported health complaints in women with breast cancer compared to healthy controls

et al. 2016

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“…If targeted appropriately, these factors are potentially modifiable and suggest an important role for providers in effectively communicating that adherence to ETs for the duration of treatment is an essential part of ensuring optimal breast cancer outcomes. Educational tools can potentially be useful in this setting by helping women understand the risks and benefits of ET, as well as by providing accurate information regarding side effects associated with ET [25]. Our analysis of a subsample of women (n 5 1,371) from the present research who completed a self-reported ET adherence measure 2 weeks after the initial assessment revealed high rates of adherence [26].…”

Section: Discussionmentioning

confidence: 90%

Symptoms and Symptom Attribution Among Women on Endocrine Therapy for Breast Cancer

et al. 2015

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Background. Adherence to adjuvant endocrine therapy (ET) influences breast cancer survival. Because ET side effects are frequently cited as reasons for nonadherence, understanding how perceptions and motivations in relation to ET are associated with symptom attribution can help promote timely symptom management. Materials and Methods. Participants were 2,086 breast cancer survivors recruited through the Army of Women registry who were current tamoxifen or aromatase inhibitor (AI) users. Participants reported whether they were bothered by each of 47 symptoms during the past month and whether they thought each symptom was related to taking ET. Frequencies of overall symptoms and symptoms attributed and misattributed to ET were calculated, and linear regression was used to assess sociodemographics, emotions, and illness perceptions as predictors of symptoms attributed to ET.

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“…Increasing knowledge of side effects, communicating the benefits of the prescribed medication to improve adherence motivation, and identifying opportunities to resolve barriers to medication use (such as side effects) have been highlighted in reviews as critical components in a long-term adherence model in clinical practice (Accordino & Hershman, 2013; DiMatteo, Haskard-Zolnierek, & Martin, 2012). Oncology nurses can play an important role in informing patients about expected risk and side effects, which could prevent early disruptions in adherence (Heisig et al, 2015) and facilitate shared decision making. Additional tools, for use by physicians and other members of the oncology team (Taplin, Foster, & Shortell, 2013), are also needed to specifically assess and monitor symptoms before symptom burden becomes intolerable.…”

Section: Implications For Nursing and Intervention Opportunitiesmentioning

confidence: 99%

Deconstructing Decisions to Initiate, Maintain, or Discontinue Adjuvant Endocrine Therapy in Breast Cancer Survivors: A Mixed-Methods Study

Bluethmann

Murphy

Tiro

et al. 2017

ONF

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Purpose/Objectives Adjuvant endocrine therapy (AET) has been shown to improve survival in hormone receptor–positive breast cancer survivors, but as many as half do not complete recommended treatment. Management of medication-related side effects and engagement with providers are two potentially modifiable factors, but their associations with adherence are not well understood. The aims were to build on survey results to qualitatively explore survivors’ experiences with prescribed AET to (a) describe appraisal and management of AET side effects and (b) deconstruct decisions to initiate, discontinue, or maintain AET. Research Approach The authors used a mixed-methods explanatory sequence research design with a qualitative emphasis. Setting Survivors were recruited from a clinical cancer registry maintained at the University of Texas Southwestern Medical Center, which includes the Harold C. Simmons Comprehensive Cancer Center (National Cancer Institute–designated), in Dallas. Participants 452 survivors completed a survey, and 30 took part in telephone interviews. Methodologic Approach Qualitative methods were used in which the authors recorded and transcribed interviews for analysis and used open coding to reduce data into themes. Findings Among adherent survivors, the themes of tolerance of side effects and perseverance were strong. Nonadherent survivors expressed more difficulty managing side effects and perceived fewer benefits when side effects were bothersome. The most common side effects mentioned by all survivors were menopausal symptoms and joint pain; less common side effects were cognitive decline and cardiac distress. Some sought advice from their oncology team. Nonadherent survivors appeared initially motivated to maintain AET but identified a tolerance limit for side effects after which a provider’s recommendation was less influential in their decision to maintain or discontinue AET. Interpretation This study elucidated adherence as a complex continuum of behaviors, appraisals, and decision points. These insights may be particularly useful in counseling survivors taking AET and promoting timely delivery of clinical interventions to enhance adherence. Implications for Nursing Nurses should be involved in the planning and implementation of clinical interventions to manage side effects and other barriers to AET adherence.

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Informing women with breast cancer about endocrine therapy: effects on knowledge and adherence

Cited by 61 publications

References 38 publications

Fatigue, anxiety and depression overrule the role of oncological treatment in predicting self-reported health complaints in women with breast cancer compared to healthy controls

Fatigue, anxiety and depression overrule the role of oncological treatment in predicting self-reported health complaints in women with breast cancer compared to healthy controls

Symptoms and Symptom Attribution Among Women on Endocrine Therapy for Breast Cancer

Deconstructing Decisions to Initiate, Maintain, or Discontinue Adjuvant Endocrine Therapy in Breast Cancer Survivors: A Mixed-Methods Study

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