Information processing through a bio-based redox capacitor: Signatures for redox-cycling

Liu, Yi; Kim, Eunkyoung; White, Ian M.; Bentley, William E.; Payne, Gregory F.

doi:10.1016/j.bioelechem.2014.03.012

Cited by 32 publications

(42 citation statements)

References 70 publications

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“…While much recent interest in redox-capacitors is focused on energy storage applications, our interest in the catechol-chitosan redox-capacitor is focused on its information processing capabilities [234]. In essence, because the grafted catechol-moieties can reversibly accept, store and donate electrons, they confer six characteristic "molecular electronic" properties to the chitosan film as outlined in Table 5.…”

Section: Information Processing Properties Of the Redox-capacitormentioning

confidence: 99%

“…For instance, the amplification properties of the redox-capacitor could enhance sensitivities for detecting the bacterial virulence factor pyocyanin [235] and the antipsychotic medication clozapine [236], while the combination of amplification and rectification provided signatures of biologically relevant redox-cycling activities (e.g., of the analgesic, acetaminophen) [234,237]. Table 5.…”

Section: Information Processing Properties Of the Redox-capacitormentioning

confidence: 99%

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Chitosan to Connect Biology to Electronics: Fabricating the Bio-Device Interface and Communicating Across This Interface

et al. 2014

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Individually, advances in microelectronics and biology transformed the way we live our lives. However, there remain few examples in which biology and electronics have been interfaced to create synergistic capabilities. We believe there are two major challenges to the integration of biological components into microelectronic systems: (i) assembly of the biological components at an electrode address, and (ii) communication between the assembled biological components and the underlying electrode. Chitosan OPEN ACCESSPolymers 2015, 7 2 possesses a unique combination of properties to meet these challenges and serve as an effective bio-device interface material. For assembly, chitosan's pH-responsive film-forming properties allow it to "recognize" electrode-imposed signals and respond by self-assembling as a stable hydrogel film through a cathodic electrodeposition mechanism. A separate anodic electrodeposition mechanism was recently reported and this also allows chitosan hydrogel films to be assembled at an electrode address. Protein-based biofunctionality can be conferred to electrodeposited films through a variety of physical, chemical and biological methods. For communication, we are investigating redox-active catechol-modified chitosan films as an interface to bridge redox-based communication between biology and an electrode. Despite significant progress over the last decade, many questions still remain which warrants even deeper study of chitosan's structure, properties, and functions.

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Section: Information Processing Properties Of the Redox-capacitormentioning

confidence: 99%

Section: Information Processing Properties Of the Redox-capacitormentioning

confidence: 99%

Chitosan to Connect Biology to Electronics: Fabricating the Bio-Device Interface and Communicating Across This Interface

et al. 2014

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“…Chemical and especially biomolecular computing, as well as other systems that involve (bio)chemical analytes constituting input signals and/or output, the latter being of interest in biosensing, forensics, and other applications, have become important fields of research as subfields of signal and information processing and unconventional computing . Extensive recent theoretical and experimental developments have laid out the foundations for design of novel systems and devices that involve conversion of biological and/or (bio)chemical signals into digital binary‐type YES/NO responses.…”

Section: Introductionmentioning

confidence: 99%

Design of High Quality Chemical XOR Gates with Noise Reduction

2017

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We describe a chemical XOR gate design that realizes gate‐response function with filtering properties. Such gate‐response function is flat (has small gradients) at and in the vicinity of all the four binary‐input logic points, resulting in analog noise suppression. The gate functioning involves cross‐reaction of the inputs represented by pairs of chemicals to produce a practically zero output when both are present and nearly equal. This cross‐reaction processing step is also designed to result in filtering at low output intensities by canceling out the inputs if one of the latter has low intensity compared with the other. The remaining inputs, which were not reacted away, are processed to produce the output XOR signal by chemical steps that result in filtering at large output signal intensities. We analyze the tradeoff resulting from filtering, which involves loss of signal intensity. We also discuss practical aspects of realizations of such XOR gates.

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“…Substantial work designing such multi‐input processes to experimentally realize and theoretically optimize their setup for high‐quality “digitized” outputs has been carried out in the field of biomolecular computing. This is accomplished by developing biocatalytic (typically, enzymatic) assays supplemented with additional biocatalytic or simple chemical‐reaction processes, the latter involving either inputs

x_{j}

or outputs

y_{j},

which act as “filters” to practically eliminate analog noise and variation in the signals …”

Section: Introductionmentioning

confidence: 99%

Promises and Challenges in Continuous Tracking Utilizing Amino Acids in Skin Secretions for Active Multi‐Factor Biometric Authentication for Cybersecurity

2017

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We consider a new concept of biometric‐based cybersecurity systems for active authentication by continuous tracking, which utilizes biochemical processing of metabolites present in skin secretions. Skin secretions contain a large number of metabolites and small molecules that can be targeted for analysis. Here we argue that amino acids found in sweat can be exploited for the establishment of an amino acid profile capable of identifying an individual user of a mobile or wearable device. Individual and combinations of amino acids processed by biocatalytic cascades yield physical (optical or electronic) signals, providing a time‐series of several outputs that, in their entirety, should suffice to authenticate a specific user based on standard statistical criteria. Initial results, motivated by biometrics, indicate that single amino acid levels can provide analog signals that vary according to the individual donor, albeit with limited resolution versus noise. However, some such assays offer digital separation (into well‐defined ranges of values) according to groups such as age, biological sex, race, and physiological state of the individual. Multi‐input biocatalytic cascades that handle several amino acid signals to yield a single digital‐type output, as well as continuous‐tracking time‐series data rather than a single‐instance sample, should enable active authentication at the level of an individual.

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Information processing through a bio-based redox capacitor: Signatures for redox-cycling

Cited by 32 publications

References 70 publications

Chitosan to Connect Biology to Electronics: Fabricating the Bio-Device Interface and Communicating Across This Interface

Chitosan to Connect Biology to Electronics: Fabricating the Bio-Device Interface and Communicating Across This Interface

Design of High Quality Chemical XOR Gates with Noise Reduction

Promises and Challenges in Continuous Tracking Utilizing Amino Acids in Skin Secretions for Active Multi‐Factor Biometric Authentication for Cybersecurity

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