Information Processing in Borderline Patients

Schubert, Donald L.; Saccuzzo, Dennis P.; Braff, David L.

doi:10.1097/00005053-198501000-00004

Cited by 17 publications

(15 citation statements)

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“…Our results are consistent with the previous positive study of primarily unmedicated subjects (Stevens et al, 2004); while the only negative study (Schubert et al, 1985) used a small sample of predominately medicated subjects (including 50% receiving antidepressants, with half of those receiving adjunctive antipsychotics, and 25% receiving sedatives). It is unclear if medication status plays a role in suppressing this deficit -it does not in schizophrenia -but degree of BPD symptom control may.…”

Section: Discussionsupporting

confidence: 91%

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Early visual information processing deficit in depression with and without Borderline Personality Disorder

Keilp

Klain

Brodsky

et al. 2007

Psychiatry Research

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Backward masking is a measure of early visual information processing usually abnormal in psychotic disorders. Previous studies of subjects with Borderline Personality Disorder have been inconsistent regarding their impairment or lack of impairment on backward masking. We examined visual backward masking performance in samples of unmedicated depressed patients with (n=12) and without (n=16) Borderline Personality Disorder, and healthy volunteers (n=18). Accuracy was poorer in depressed BPD patients, relative to both non-BPD depressed and healthy comparison subjects. As in previous studies, no differences in accuracy were found between non-BPD depressed patients and healthy comparison subjects. Differences in BPD subjects' accuracy were most evident at the fastest ISI and were not attributable to intercurrent psychotic symptoms. Beyond these group differences, accuracy at faster ISI's correlated with self-ratings of impulsiveness in all patients, and may be a general correlate of this trait. Poor early information processing appears to be a feature of Borderline Personality Disorder, and may play a role in the impulsive behavior that is characteristic of the disorder.

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Section: Discussionsupporting

confidence: 91%

“…The first found no differences between a small group of BPD subjects (n=8) and both non-psychotically depressed patients and non-patients (Schubert et al, 1985). Two comparison samples of schizoaffective and manic bipolar subjects performed more poorly than these other groups.…”

Section: Introductionmentioning

confidence: 92%

Early visual information processing deficit in depression with and without Borderline Personality Disorder

Keilp

Klain

Brodsky

et al. 2007

Psychiatry Research

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“…23,24 Most investigations revealing backward masking dysfunction in bipolar patients employed paradigms requiring the participant to determine the identity of objects (ie, a P-system-biased task) 25,26 or studied bipolar disorder participants with ongoing psychotic symptomatology. 27,28 When M-biased tasks have been used, different patterns of masking for bipolar disorder and schizophrenia patients are evident. 17,29 Specifically, bipolar disorder patients with mild symptomatology generally fail to show a backward masking dysfunction, 30,31 and instead lifetime history of psychosis in bipolar disorder appears predictive of increased errors on backward masking paradigms.…”

Section: Introductionmentioning

confidence: 99%

Fragile Early Visual Percepts Mark Genetic Liability Specific to Schizophrenia

Sponheim

Sass

Noukki

et al. 2012

Schizophrenia Bulletin

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Disruption of visual percepts by a subsequent stimulus (ie, backward masking) has been consistently noted in schizophrenia, with some evidence that this fragility in early perception is present in people with genetic liability for the disorder. Given the potential of backward masking paradigms to mark neural processes that confer risk for schizophrenia, it is important to test the diagnostic specificity of abnormalities in visual perception. To more fully assess whether masking visual stimuli reveals a marker of genetic liability (ie, endophenotype) specific to schizophrenia, we tested 44 people with the disorder, 29 people with bipolar disorder, 56 first-degree biological relatives of people with schizophrenia, 26 first-degree biological relatives of people with bipolar disorder, and 43 nonpsychiatric control participants using a magnocellular-biased visual backward masking procedure that included target-to-mask onset asynchronies ranging from 0 to 80 ms. Relatives of people with schizophrenia who were without schizophrenia spectrum disorders exhibited impaired performance compared with nonpsychiatric control participants and relatives of people with bipolar disorder when a visual mask interrupted early perception (eg, 27 ms). A similar vulnerability of early processes was noted in people with schizophrenia, yet they also had impaired performance when masks occurred at later time points (ie, 80 ms). Performance deficits were not attributable to intellectual function, measures of attention and memory, symptomatology, or medication dosage. Bipolar patients and their relatives failed to exhibit deficits on the backward masking task. Fragility of early visual percepts appears to mark genetic liability specific to schizophrenia and may serve as an endophenotype for the disorder.

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“…Visual backward masking (VBM) is one such paradigm, and it has been extensively employed to study information processing deficits in patients with schizophrenia (Braff, 1981 ;Saccuzzo & Braff, 1981 ;Green & Walker, 1986 ;Schuck & Lee, 1989 ;Rund et al 1996). To a lesser extent the performance of patients with bipolar disorder has been examined, but these studies have been largely confined to acutely manic, psychotic patients (Schubert, 1985 ;Green & Walker, 1986 ;Saccuzzo & Braff, 1986) or patients who were not yet discharged following a manic episode (Fleming & Green, 1995). Other studies in BD focused on the neural pathways that may underlie impairment in BD but were conducted on chronic, hospitalized patients, most of whom required antipsychotic medication at the time of assessment (Green et al 1994 a, b).…”

Section: Introductionmentioning

confidence: 99%

Backward masking task performance in stable, euthymic out-patients with bipolar disorder

et al. 2001

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These results are consistent with previous reports of neuropsychological deficits in euthymic bipolar disorder patients. The potential benefit to employing tasks such as VBM is that it may provide a method for relating clinical variables such as illness burden with known neural pathways in order to elucidate better the pathophysiology leading to impaired cognitive performance in patients with bipolar disorder.

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Information Processing in Borderline Patients

Cited by 17 publications

References 0 publications

Early visual information processing deficit in depression with and without Borderline Personality Disorder

Early visual information processing deficit in depression with and without Borderline Personality Disorder

Fragile Early Visual Percepts Mark Genetic Liability Specific to Schizophrenia

Backward masking task performance in stable, euthymic out-patients with bipolar disorder

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