Isospin symmetry breaking (ISB) effects in the charge radius difference ∆R ch of mirror nuclei are studied using the test example of 48 Ca and 48 Ni. This choice allows for a transparent study of ISB contributions since paring and deformation effects, commonly required for the study of mirror nuclei, can be neglected in this specific pair. The connection of ∆R ch with the nuclear Equation of State and the effect of ISB on such a relation are discussed according to an Energy Density Functional approach. We find that nuclear ISB effects may shift the estimated value for the symmetry energy slope parameter L by more than 10 MeV while Coulomb corrections can be neglected. ISB effects on the ground-state energy and charge radii in mirror nuclei have been recently predicted by ab initio calculations to be relatively small, pointing to a negligible effect for the extraction of information on the nuclear EoS. These contrasting results call for a dedicated theoretical effort to solve this overarching problem that impacts not only the neutron skin thickness or the difference in mass and charge radii of mirror nuclei but also other observables such as the Isobaric Analog State energy.