Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a secondary care setting

Harrison, Jennifer; Fearon, Patricia; Noel-Storr, Anna; McShane, Rupert; Stott, David J.; Quinn, Terence J.

doi:10.1002/14651858.cd010772.pub2

Cited by 90 publications

(93 citation statements)

References 112 publications

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“…Because there is evidence of redundancy in the full SIS, a short form approach is attractive. Where short forms of lengthy questionnaires are available, they can often replace the original as the test of choice; for example, the short form (16 items) of the Informant Questionnaire for Cognitive Decline in the Elderly is now the preferred version,17 and the recently described short form of the Parkinson's Disease Questionnaire18 is now commonly used 19. Short forms may have particular use in situations where time available for testing is limited or when used as a component of an outcomes battery in a large clinical trial.…”

Section: Discussionmentioning

confidence: 99%

Derivation and Validation of a Modified Short Form of the Stroke Impact Scale

MacIsaac

Ali

Peters

et al. 2016

JAHA

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BackgroundThe Stroke Impact Scale (SIS) is a stroke‐specific, quality of life measure recommended for research and clinical practice. Completion rates are suboptimal and could relate to test burden. We derived and validated a short form SIS (SF‐SIS).Methods and ResultsWe examined data from the Virtual International Stroke Trial Archive, generating derivation and validation populations. We derived an SF‐SIS by selecting 1 item per domain of SIS, choosing items most highly correlated with total domain score. Our validation described agreement of SF‐SIS with original SIS and the SIS‐16 and correlation with Barthel Index, modified Rankin Scale, National Institutes of Health Stroke Scale, and Euro‐QoL 5 dimensions visual analog scales. We assessed discriminative validity (associations between SF‐SIS and factors known to influence outcome [age, physiological parameters, and comorbidity]). We assessed face validity and acceptability by sharing the SF‐SIS with a focus group of stroke survivors and multidisciplinary stroke healthcare staff. From 5549 acute study patients (mean age 68.5 [SD 13] years, mean SIS 64 [SD 32]) and 332 rehabilitation patients (mean age 65.7 [SD 11] years, mean SIS 61 [SD 11]), we derived an 8‐item SF‐SIS that demonstrated good agreement with original SIS and good correlation with our chosen functional and quality of life measures (all ρ>0.70, P<0.0001). Significant associations were seen with our chosen predictors of stroke outcome in the acute group (P<0.0001). The focus group agreed with the choice of items for SF‐SIS across 7 of 8 domains. ConclusionsUsing multiple, complementary methods, we have derived an SF‐SIS and demonstrated content, convergent, and discriminant validity. This shortened SIS should allow collection of robust quality of life data with less associated test burden.

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Section: Discussionmentioning

confidence: 99%

Derivation and Validation of a Modified Short Form of the Stroke Impact Scale

MacIsaac

Ali

Peters

et al. 2016

JAHA

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“…Therefore, we may have underestimated the weight of cognitive decline in our ICH cohort. A recent Cochrane review 26 suggests that an (average) IQCODE cutoff ≈3.3 should be used to screen for dementia. However, the PITCH cohort was designed in 2003 when recommendations on the IQCODE suggested a cutoff of 4.0.…”

Section: Discussionmentioning

confidence: 99%

“…12 Although this may have resulted in an underestimation of the prevalence of preexisting dementia, in an additional analysis, we applied the more stringent criteria recommended by the recent Cochrane review 26 by excluding patients with preexisting cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors for Cognitive Decline After Intracerebral Hemorrhage

Benedictus

Hochart

Rossi³

et al. 2015

Stroke

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Background and Purpose-Stroke and dementia are closely related, but no prospective study ever focused on poststroke cognitive decline in patients with intracerebral hemorrhage (ICH). We aimed to determine prognostic factors for cognitive decline in patients with ICH. Methods-We prospectively included 167 consecutive ICH survivors without preexisting dementia from the Prognosis of Intra-Cerebral Hemorrhage (PITCH) cohort. Median follow-up was 4 years (interquartile range, 2.3-5.4). We explored factors associated with cognitive decline using linear mixed models. Cognitive decline was determined based on repeated mini-mental state examination. We investigated each prognostic factor separately in univariate models. Next, we constructed clinical and radiological multivariable models. In a sensitivity analysis, we excluded patients with preexisting cognitive impairment. Results-Median age was 64 (interquartile range, 53-75) years, 69 (41%) patients were women, and median mini-mental state examination at 6 months was 27 (interquartile range, 23-29

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“…To date, the IQCODE has been used predominantly as a screening measure for dementia, either in the community [19] , or in hospital and geriatric care settings [20] . But, the IQCODE may be a useful measure to elucidate further the relations between cognitive change and activity engagement over time in the cognitively healthy.…”

Section: Introductionmentioning

confidence: 99%

Informant-Reported Cognitive Decline and Activity Engagement across Four Years in a Community Sample

et al. 2017

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Background: Subtle age-related cognitive decline may be associated with the capacity to remain engaged in mental, physical, and social activities. Informant reports of cognitive decline potentially provide additional information to psychometric tests on change in everyday cognitive function relevant to activity engagement. Objective: To investigate relations between decline in everyday cognitive function as assessed by informant report and activity engagement in community-dwelling older adults. Methods: A sample of cognitively normal older adults was drawn from the 2 latest waves of the PATH Through Life Study (n = 1,391; mean age 74.5 ± 1.5, 48.4% female). PATH is a 16-year longitudinal cohort study set in the Canberra/Queanbeyan district, Australia. Assessments were carried out at baseline, and at 3 subsequent time-points 4 years apart. At wave-4, the IQCODE, an informant measure of 4-year cognitive decline was provided by a spouse, family member, or friend of each participant. Activity engagement was assessed by the abbreviated RIASEC Mental Activity List, self-reported frequency and duration of physical activity (Whitehall Questionnaire) and the Lubben Social Network Scale that assessed interaction with family/friends. Participants provided demographic information, self-reported health status (SF-12), and responses to the Goldberg Depression Scale. The Symbol Digit Modalities Test (SDMT) and California Verbal Learning Test (CVLT) were used to measure objective 4-year cognitive change. Those with MMSE score of ≤27 were excluded. Results: IQCODE score predicted disengagement from mental activities over 4 years in cognitively healthy adults (β = -0.056, standard error [SE] = 0.019, p = 0.004). This association was robust to covariate control and change on the SDMT which was also significantly related to mental activity disengagement. In models adjusted for change scores on the SDMT and the CVLT, the IQCODE was associated with less physical (β = -0.692, SE = 0.24, p = 0.004) and social engagement (β -0.046, SE = 0.021, p = 0.032), but relationships were attenuated with the inclusion of covariates. Conclusion: Informant-reported cognitive decline in a non-clinical sample was linked to activities that support cognitive health. Associations were robust to adjustment for cognitive change scores. Utilising informant reports prior to the manifestation of clinically relevant decline may identify those who would benefit most from personalised activity interventions.

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Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a secondary care setting

Cited by 90 publications

References 112 publications

Derivation and Validation of a Modified Short Form of the Stroke Impact Scale

Derivation and Validation of a Modified Short Form of the Stroke Impact Scale

Prognostic Factors for Cognitive Decline After Intracerebral Hemorrhage

Informant-Reported Cognitive Decline and Activity Engagement across Four Years in a Community Sample

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