Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the detection of dementia within community dwelling populations

Quinn, Terry; Fearon, Patricia; Noel-Storr, Anna; Young, Camilla; McShane, Rupert; Stott, David J.

doi:10.1002/14651858.cd010079.pub3

Cited by 6 publications

(12 citation statements)

References 96 publications

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“…The fundamental core of the website includes the assessment of the potential patient. This is done through the versions validated in Spain of the two questionnaires that are most widely used for the detection of dementia based on the data given by an informant: the IQCODE and AD8 questionnaires ( Hendry et al, 2019 ; Burton et al, 2021 ; Quinn et al, 2021 ). The inclusion of both instruments was designed to compare the performance of both questionnaires and possibly to decide to use only one in the case of developing a shortened version for the website.…”

Section: Discussionmentioning

confidence: 99%

Does Your Loved One With Cognitive Symptoms Need to See a Doctor? Check It Online

Agüera-Ortíz

Martı́n-Carrasco

Arriola-Manchola

et al. 2022

Front. Comput. Neurosci.

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Widespread access to emerging information and communication technologies (ICT) allows its use for the screening of diseases in the general population. At the initiative of the Spanish Confederation of Associations of Families of People with Alzheimer’s disease and other dementias (CEAFA), a website (http://www.problemasmemoria.com) has been created that provides information about Alzheimer’s disease and includes questionnaires to be completed by family or friends concerned about memory problems of a relative. A cross-sectional, randomized, multicenter study was performed to evaluate feasibility, validity, and user satisfaction with an electronic method of completion vs. the current method of paper-based questionnaires for clinically dementia screening completed by the informants: the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and the Alzheimer’s disease-8 screening test (AD8). A total of 111 pairs were recruited by seven memory clinics. Informants completed IQCODE and AD8 questionnaires both in their paper and electronic versions. The correlation between paper and electronic versions was significantly positive for IQCODE (r = 0.98; p < 0.001) and AD8 (r = 0.96; p < 0.001). The execution time did not differ significantly, and participants considered their use equally easy. This study shows that an electronic version of the IQCODE and AD8 questionnaires is suitable for its online use via the internet and achieves the same results as the traditional paper versions.

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Section: Discussionmentioning

confidence: 99%

Does Your Loved One With Cognitive Symptoms Need to See a Doctor? Check It Online

Agüera-Ortíz

Martı́n-Carrasco

Arriola-Manchola

et al. 2022

Front. Comput. Neurosci.

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“…Various cut points are used to capture cognitive impairment in community samples, typically ranging from 3.3 to 3.6. 22 For this study, IQCODE >3.3 and >3.6 were considered. To inform choice of cognitive endpoint, we tested the association of each score cross‐sectionally at baseline with apolipoprotein E ( APOE ) ε4 status in the whole PROTECT sample ( N = 6151).…”

Section: Methodsmentioning

confidence: 99%

“…The final IQCODE score is obtained by taking the mean of the 16 items. Various cut points are used to capture cognitive impairment in community samples, typically ranging from 3.3 to 3.6 22 . For this study, IQCODE >3.3 and >3.6 were considered.…”

Section: Methodsmentioning

confidence: 99%

Late‐life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease

Creese

Arathimos

Aarsland

et al. 2023

A&D Transl Res & Clin Interv

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Introduction Late‐life onset psychosis is associated with faster progression to dementia in cognitively normal people, but little is known about its relationship with cognitive impairment in advance of dementia. Methods Clinical and genetic data from 2750 people ≥50 years of age without dementia were analyzed. Incident cognitive impairment was operationalized using the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and psychosis was rated using the Mild Behavioral Impairment Checklist (henceforth MBI‐psychosis). The whole sample was analyzed before stratification on apolipoprotein E ( APOE ) ε4 status. Results In Cox proportional hazards models, MBI‐psychosis had a higher hazard for cognitive impairment relative to the No Psychosis group (hazard ratio [HR]: 3.6, 95% confidence interval [CI]: 2.2–6, p < 0.0001). The hazard for MBI‐psychosis was higher in APOE ε4 carriers and there was an interaction between the two (HR for interaction: 3.4, 95% CI: 1.2–9.8, p = 0.02). Discussion Psychosis assessment in the MBI framework is associated with incident cognitive impairment in advance of dementia. These symptoms may be particularly important in the context of APOE genotype.

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“…Information on medical history and medication will be obtained. The Informant Questionnaire on Cognitive Decline in the Elderly,30 31 which has been used in previous studies to screen for pre-stroke cognitive impairment,32 will be used to screen for pre-TBI cognitive impairment for patients without a formal dementia diagnosis.…”

Section: Methods and Analysismentioning

confidence: 99%

Using home monitoring technology to study the effects of traumatic brain injury on older multimorbid adults: protocol for a feasibility study

et al. 2023

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IntroductionThe prevalence of traumatic brain injury (TBI) among older adults is increasing exponentially. The sequelae can be severe in older adults and interact with age-related conditions such as multimorbidity. Despite this, TBI research in older adults is sparse. Minder, an in-home monitoring system developed by the UK Dementia Research Institute Centre for Care Research and Technology, uses infrared sensors and a bed mat to passively collect sleep and activity data. Similar systems have been used to monitor the health of older adults living with dementia. We will assess the feasibility of using this system to study changes in the health status of older adults in the early period post-TBI.Methods and analysisThe study will recruit 15 inpatients (>60 years) with a moderate-severe TBI, who will have their daily activity and sleep patterns monitored using passive and wearable sensors over 6 months. Participants will report on their health during weekly calls, which will be used to validate sensor data. Physical, functional and cognitive assessments will be conducted across the duration of the study. Activity levels and sleep patterns derived from sensor data will be calculated and visualised using activity maps. Within-participant analysis will be performed to determine if participants are deviating from their own routines. We will apply machine learning approaches to activity and sleep data to assess whether the changes in these data can predict clinical events. Qualitative analysis of interviews conducted with participants, carers and clinical staff will assess acceptability and utility of the system.Ethics and disseminationEthical approval for this study has been granted by the London-Camberwell St Giles Research Ethics Committee (REC) (REC number: 17/LO/2066). Results will be submitted for publication in peer-reviewed journals, presented at conferences and inform the design of a larger trial assessing recovery after TBI.

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Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the detection of dementia within community dwelling populations

Cited by 6 publications

References 96 publications

Does Your Loved One With Cognitive Symptoms Need to See a Doctor? Check It Online

Does Your Loved One With Cognitive Symptoms Need to See a Doctor? Check It Online

Late‐life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease

Using home monitoring technology to study the effects of traumatic brain injury on older multimorbid adults: protocol for a feasibility study

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