Info-activity of the immune system from the perspective of the informational model of the human body and living structures

Abstract

In this paper it is demonstrated the informational nature of the activity of the immune system, and its role within the informational system of the human body, on the basis of the informational concept defined as matter-related information. This concept is derived from the observation that the interactions between the micro-material particles of the human body are under a permanent dynamic process, forming complex compounds or decomposing in constitutive components, with absorption and release of information. On the basis of this concept, it is possible to describe coherently on one hand the metabolic and genetic processes from informational perspective, for the body maintenance and its growth/development or the plasticity of parts of it, and on the other hand the info-relation between its components, based on the “language” compatibility and right communicational operability between micro-material informational agents carrying the information to the brain, the central managing operator/processor of the entire organism, and between them themselves. The identification of the specific distinct components of the informational system of the human body allows to describe it as a communication between brain and body, performed mainly by YES/NO binary-Bit-type mechanisms, both at the macro and microscopic level of the constitutive cells. The analysis of the immune system within this context and as a part of the informational system of the human body, allows to highlight that this activity can be described by the same concept of information, showing that the basic operative informational processes consists in combined genetic and communication mechanisms, as the informational model of the human body and living structures and its concepts predicts and demonstrates.

The Informational Model of the Human Body and Living Structures: from Micro to Macro Structuration and Functions

“…The basal ganglia are also involved in the personality features. The immune system, a complex organization of mobile cells, fighting against the local microorganisms investors, and stable organs (thymus, spleen, lymph vessels and nodes), is managed also by the hypophysis/hypothalamus axis, involving an intensive and precise micro/macro informational activity between cells spread in the entire human/mammals' body themselves and brain, exhibiting a relevant example of info-coordination/info-communication on the tridimensional (3D) map of the organism [39,40].…”

“…The intercommunication between cells in multicellular organisms is performed by endocrine/paracrine/direct-contact/autocrine signaling, necessary to make them "aware" of the neighboring cells, and they work/act according to these signalization [64] (so as cognitive systems/components: (i) endocrine is a long-distance communication supported by hormones, circulating in the blood/fluids circuits of the multicellular organisms; (ii) paracrine is a short-distance communication by diffusion of info-agents (in particular neurotransmitters) between neighbor cells (like in the nervous synapses); (iii) direct-contact communication is performed through gap junctions (intercellular micro-bridges/channels between neighbor cell membrane in animals) or plasmodesmata (microscopic channels in plants for the transit only of small molecules and ions); (iv) distinctively, autocrine is the communication with the cell itself (the cell secrets an info-chemical agent which is received by its own surface membrane receptors, as a self-communication forward-feedback loop response/circuit). Such type of communication works both in unicellular (quorum sensing) and multicellular organisms (engaged in cardiac remodeling/heart failure), selfsustaining growth of cancer cells (by dysfunctional activity of cells' IC [39,40]) and inflammations by grow factor (small polypeptides that stimulate and promote cell differentiation/division), in macrophage mechanisms of white molecules (for elimination of cellular debris and foreign particles) in the immune system. The quorum sensing is a special intercommunication of bacteria in various "languages" [65] with themselves and others, which induces a population with a critical density level, requiring a regulatory process for making a "consensual" decision on the chain CASI/IRSS/IC/CDC.…”