Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system

Chen, Qing‐Yun; Liu, Yinping; Lu, Aizhen; Ni, Ke; Xiang, Zheng; Wen, Kun; Tu, Wenwei

doi:10.1016/j.jaut.2016.10.006

Cited by 29 publications

(21 citation statements)

References 40 publications

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“…During the development of EAE disease following influenza infection, CCL5 / CCR5 may mediate the type I T cells infiltration into the CNS. Administration of the CCR5 antagonist, TAK-779, significantly ameliorated the exacerbated EAE [24].…”

Section: Ccr5 Antagonistsmentioning

confidence: 95%

“…Maraviroc (Celsentri TM ) is the first CCR5 antagonist that approved for the treatment of HIV-1 infection by EMA (European Medicines Agency) [24]. Together with the approved use of AMD3100 (CXCR4 antagonist) and a large number of clinical trials of small molecules and biologics currently underway, reflecting the belief that chemokine systems serve as therapeutic targets for treatment [103].…”

Section: Ccr5 Antagonistsmentioning

confidence: 99%

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The role of chemokines and chemokine receptors in multiple sclerosis

Cui

Chu

Chen

2020

International Immunopharmacology

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Multiple sclerosis (MS) is a chronic inflammatory disease that is characterized by leukocyte infiltration and subsequent axonal damage, demyelinating inflammation, and formation of sclerosing plaques in brain tissue. The results of various studies in patients indicate that autoimmunity and inflammation make an important impact on the pathogenesis of MS. Chemokines are key mediators of inflammation development and cell migration, mediating various immune cell responses, including chemotaxis and immune activation, and are important in immunity and inflammation, therefore we focus on chemokines and their receptors in multiple sclerosis. In this article, we summarize the study of the role of prominent chemokines and their receptors in MS patients and MS animal modelsand discuss their potential significance in inflammatory injury and repair of MS. We have also summarized the progress in the treatment of multiple sclerosis antagonists in recent years with chemokine receptors as targets.

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Section: Ccr5 Antagonistsmentioning

confidence: 95%

Section: Ccr5 Antagonistsmentioning

confidence: 99%

The role of chemokines and chemokine receptors in multiple sclerosis

Cui

Chu

Chen

2020

International Immunopharmacology

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“…Animal models have shown that, using either the olfactory route or vagus nerve, influenza A virus may have access to the CNS and alter the hippocampus and the regulation of neurotransmission, while affecting cognition and behavior as long-term sequelae [8,69,[159][160][161][162]. The influenza A virus has also been associated with the risk of developing Parkinson's disease (PD) [151] and has recently been shown to exacerbate experimental autoimmune encephalomyelitis (EAE), which is reminiscent of the observation that multiple sclerosis (MS) relapses have been associated with viral infections (including influenza A) of the upper respiratory tract [163][164][165].…”

Section: Respiratory Viruses With Neuroinvasive and Neurotropic Propementioning

confidence: 99%

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

Desforges

Coupanec

Dubeau

et al. 2019

Viruses

933

997

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Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). Respiratory viruses can also exacerbate asthma and lead to various types of respiratory distress syndromes. Furthermore, as they can adapt fast and cross the species barrier, some of these pathogens, like influenza A and SARS-CoV, have occasionally caused epidemics or pandemics, and were associated with more serious clinical diseases and even mortality. For a few decades now, data reported in the scientific literature has also demonstrated that several respiratory viruses have neuroinvasive capacities, since they can spread from the respiratory tract to the central nervous system (CNS). Viruses infecting human CNS cells could then cause different types of encephalopathy, including encephalitis, and long-term neurological diseases. Like other well-recognized neuroinvasive human viruses, respiratory viruses may damage the CNS as a result of misdirected host immune responses that could be associated with autoimmunity in susceptible individuals (virus-induced neuro-immunopathology) and/or viral replication, which directly causes damage to CNS cells (virus-induced neuropathology). The etiological agent of several neurological disorders remains unidentified. Opportunistic human respiratory pathogens could be associated with the triggering or the exacerbation of these disorders whose etiology remains poorly understood. Herein, we present a global portrait of some of the most prevalent or emerging human respiratory viruses that have been associated with possible pathogenic processes in CNS infection, with a special emphasis on human coronaviruses.

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“…HMPV [96], parainfluenza [97] and IV infection [98] or IV vaccination [94] preceding ADEM, have all been reported. Influenza infection has been shown to trigger [99] or exacerbate [100] disease in experimental autoimmune encephalomyelitis (EAE) models, which might be a useful to study ADEM [101].…”

Section: Acute Disseminated Encephalomyelitis (Adem)mentioning

confidence: 99%

Respiratory virus-induced heterologous immunity

2018

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Purpose To provide current knowledge on respiratory virus-induced heterologous immunity (HI) with a focus on humoral and cellular cross-reactivity. Adaptive heterologous immune responses have broad implications on infection, autoimmunity, allergy and transplant immunology. A better understanding of the mechanisms involved might ultimately open up possibilities for disease prevention, for example by vaccination. Methods A structured literature search was performed using Medline and PubMed to provide an overview of the current knowledge on respiratory-virus induced adaptive HI.

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Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system

Cited by 29 publications

References 40 publications

The role of chemokines and chemokine receptors in multiple sclerosis

The role of chemokines and chemokine receptors in multiple sclerosis

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

Respiratory virus-induced heterologous immunity

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