Research suggested that human infection with the novel avian influenza virus might be derived from live poultry markets. The sale of freshly slaughtered poultry, live poultry transportation, and mixed trading of different domestic animals in the live poultry markets all provide environments conducive to genome segment reassortment, gene mutation, and interspecies transmission of avian influenza virus. Production methods, human lifestyle, and the earth environment have been dramatically altered owning to rapid expansion of cities, industrialization, transportation, and accelerated population growth, in contrast to preserving traditional culture. People are exposed to the double burden of continued increasing incidence and mortality of the disease. In response to the huge challenge in the transmission of the disease, especially to prevent the spread of future avian influenza outbreaks, changing lifestyle and production habit should partly control the spread of the infections such as temporally closing live poultry markets, together with efforts to control the movement of illegal poultry products and wild birds. It is anticipated that by constantly seeking better solutions new models of living and development throughout society will gradually come into being.