Influenza virus and CNS manifestations

Sublingual vaccination with influenza virus protects mice against lethal viral infection

“…route in humans. CNS involvement is a rare complication after natural infection with influenza virus during human epidemics (21); however, the relevance of our findings using a mouse-adapted virus remains unknown. In contrast, when delivered by the s.l.…”

Neurologic Complications Associated With Influenza A in Children During the 2003–2004 Influenza Season in Houston, Texas

“…6,21,[23][24][25] In these series, a subset of patients (both children and adults) developed a newly described entity termed "acute necrotizing encephalopathy" (ANE). 14,23,26,27 Many patients with this syndrome present with high fever, seizures, and alterations in mental status that rapidly progress to coma. Brain imaging often demonstrates symmetric white matter, thalamic, basal ganglia, and/or pontine involvement.…”

Opsoclonus-Myoclonus Syndrome Following Influenza A Infection

“…Influenza-associated acute encephalopathy, including more severe acute necrotizing encephalopathy and Reye's syndrome, occurs relatively frequently and is well known (1). Recently, the cases of a 15-year-old girl with neuromyelitis optica following influenza A infection (2), an adult patient with acute motor axonal neuropathy following a pandemic H1N1 influenza A infection (3), an adult patient with acute ophthalmoparesis (4), and two children with impaired ocular movement (5) following influenza A infection have been reported.…”

“…Several neurological complications associated with influenza infection, such as encephalopathy, Reye's syndrome and myelitis, have been described (1). We encountered an adult case of opsoclonus-myoclonus syndrome (OMS) following influenza A virus infection.…”