Influenza viral glycoproteins induce cell-mediated cytotoxicity by an interferon-independent mechanism

Arora, D. J. S.; Justewicz, D M

doi:10.1016/0008-8749(86)90379-5

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…In contrast, IFN is not detectable in the early stages of influenza infection in experimental animals [Fugisawa et al, 19871. We and others showed that viral antigens induced cell mediated cytotoxicity without the concomitant release of IFN [Arora and Justewicz, 1986;Casali, et al, 19811.…”

Section: Discussionmentioning

confidence: 98%

“…Intranasal instillation of anti-IFN serum increased viral titer and host mortality [Hoshino et al, 19831. In contrast, IFN is not detectable in the early stages of influenza infection in experimental animals [Fugisawa et al, 19871. We and others showed that viral antigens induced cell mediated cytotoxicity without the concomitant release of IFN [Arora and Justewicz, 1986;Casali, et al, 19811. The exact mechanism/s induced in the protection remains unknown. Since there is a dynamic and balanced interplay present in host's complex immune system, it will be fair to conclude that no one particular mecha- "The data represent the weighted average of all observations.…”

Section: Discussionmentioning

confidence: 99%

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Administration of inactivated and detergent‐treated influenza virus to mice before virus challenge reduces mortality

Arora

1993

Journal of Medical Virology

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Formalin-inactivated virus (FIV) and the detergent-treated virus (DTV) preparations were tested for their ability to enhance the resistance of mice to experimental influenza infection. FIV (100 micrograms) was administered intravenously to mice. After 24 hr, animals were challenged with 5 LD50 dose intranasally. FIV-treated and non-treated (control) mice had 10% and 100% mortality, respectively. Similar results were obtained with the DTV (40 micrograms) preparation. The pulmonary virus titer of FIV-treated mice was lower when compared with the control. Mechanisms other than acquired immunity may have conferred the early resistance to virus infection in mice.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%