Influenza Vaccine Requirements in Pregnant Women

Nayak, Sumitha

doi:10.1007/s13224-016-0867-1

Cited by 4 publications

(4 citation statements)

References 7 publications

(23 reference statements)

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“…As an example, seasonal vaccination of pregnant women against influenza has been a recommendation of the WHO since 2005, though was not practiced widely until after the influenza pandemic of 2009. 15 During the global H1N1 pandemic, pregnant women were notably and disproportionately affected. Although pregnant women represented only 1% of the U.S. population at the time, they accounted for 5% of U.S. deaths and nearly 10% of hospitalizations related to the virus.…”

Section: Discussionmentioning

confidence: 99%

Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries

et al. 2020

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Objective Pregnant women have been historically excluded from clinical trials for nonobstetric conditions, even during prior epidemics. The objective of this review is to describe the current state of research for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Study Design We conducted a search of international trial registries for trials relating to the novel coronavirus. The eligibility criteria for each trial were reviewed for inclusion/exclusion of pregnant women. Relevant data were extracted and descriptive statistics were calculated for individual and combined data. The total number of trials from each registry were compared, as well as the proportions of pregnancy-related trials within each. Results Among 621,370 trials in the World Health Organization International Clinical Trials Registry, 927 (0.15%) were COVID-19 related. Of those, the majority (52%) explicitly excluded pregnancy or failed to address pregnancy at all (46%) and only 16 (1.7%) were pregnancy specific. When categorized by region, 688 (74.2%) of COVID-19 trials were in Asia, followed by 128 (13.8%) in Europe, and 66 (7.2%) in North America. Of the COVID-19 trials which included pregnant women, only three were randomized-controlled drug trials. Conclusion Approximately 1.7% of current COVID-19 research is pregnancy related and the majority of trials either explicitly exclude or fail to address pregnancy. Only three interventional trials worldwide involved pregnant women. The knowledge gap concerning the safety and efficacy of interventions for COVID-19 created by the exclusion of pregnant women may ultimately harm them. While “ethical” concerns about fetal exposure are often cited, it is in fact unethical to habitually exclude pregnant women from research. Key Points

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Section: Discussionmentioning

confidence: 99%

Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries

et al. 2020

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“…Various analyses of adverse event data found no evidence overall of an increased risk of adverse pregnancy outcomes following influenza vaccination in pregnancy [28][29][30][31][32][33]. Furthermore, influenza vaccine can be co-administered with tetanus-containing vaccines if the timings align, as recommended by the American College of Obstetricians and Gynecologists (ACOG) [34].…”

Section: Favorable Safety Profile Of Influenza Vaccination During Pregnancymentioning

confidence: 99%

Expert opinion on the way forward for improving maternal influenza vaccination in India

Purandare

Preiss²,

Kolhapure

et al. 2021

Expert Review of Vaccines

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Introduction: : Rates of maternal vaccination against influenza are extremely low in India. An expert panel of obstetric-gynecologists and pediatricians met to develop consensus-based recommendations for improving awareness of the benefits of influenza vaccination during pregnancy in India. Areas covered: : The group discussed experiences of influenza infection in pregnancy and infancy before focusing on maternal vaccination practices in India, including the degree of communication between obstetric-gynecologists and pediatricians and opinions on optimal timing for vaccination. The impact of inconsistent vaccine prescription practices by healthcare providers was discussed, as well as current clinical recommendations on maternal influenza vaccination. Expert opinion: : Although clinical evidence demonstrates the benefit of maternal influenza vaccination in any trimester, influenza vaccination is not widely accepted in India as an integral part of antenatal care. There is a lack of familiarity among obstetricians of clinical guidelines on maternal influenza vaccination. This can be addressed with an education campaign targeting obstetricians and other providers of maternal healthcare. With variable influenza seasons between regions in India, common vaccine stock shortages, and data suggesting influenza vaccination is feasible anytime in pregnancy, all opportunities to offer vaccination to this high-risk group for severe influenza disease should be considered.

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“…Pregnancy is concomitant with immunological and physiological changes in many organ systems. 1 These modifications may affect the immune system's response to influenza virus infection. 2 Literature on previous influenza pandemics in 1918,1957, and 2009 has demonstrated that pregnant women were at high risk of developing complications such as pneumonia, respiratory failure, intensive care admission, sepsis, and even death.…”

Section: Introductionmentioning

confidence: 99%

Primary Healthcare Physicians’ Knowledge, Practice, and Attitude Towards Influenza Vaccination of Pregnant Women in Bahrain

K. Bindayna,

A. AlHammadi,

K. Bindayna

et al. 2023

JBMS

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Background: Pregnancy is associated with immunological and physiological changes in many organ systems. Influenza in pregnancy has been associated with higher rates of morbidity and mortality. The Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) advocate antenatal influenza vaccination. Objective: This study aims to assess Primary Healthcare Physicians’ (PHPs) knowledge, practice, and attitude regarding influenza vaccination of pregnant women in Bahrain. Also, to identify the perceived facilitators and barriers to influenza vaccination for pregnant women among PHPs. Methodology: A cross-sectional study was conducted in all Primary Health Centers (PHCs) in Bahrain belonging to the Ministry of Health (MOH), which included 25 PHCs and 3 health clinics spread across five health regions. One hundred and nighty -two physicians responded to a survey about their awareness, practice, and attitude about influenza immunization in pregnancy. Conclusion: In general, physicians agree that influenza vaccination is necessary and safe for all pregnant women, not only those having high-risk pregnancies. Furthermore, good counseling can help overcome many fears or barriers.

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Influenza Vaccine Requirements in Pregnant Women

Cited by 4 publications

References 7 publications

Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries

Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries

Expert opinion on the way forward for improving maternal influenza vaccination in India

Primary Healthcare Physicians’ Knowledge, Practice, and Attitude Towards Influenza Vaccination of Pregnant Women in Bahrain

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