Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies

Restivo, Vincenzo; Costantino, Claudio; Bono, Stefania Enza; Maniglia, Marialuisa; Marchese, Valentina; Ventura, Gianmarco; Casuccio, Alessandra; Tramuto, Fabio; Vitale, Francesco

doi:10.1080/21645515.2017.1321722

Cited by 72 publications

(48 citation statements)

References 78 publications

(65 reference statements)

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“…18 Vaccine effectiveness against A/ H3 in all population groups was estimated at 25% (13% to 36%) in US primary care, similar to Canadian interim estimates of 17% (95% CI: −14% to 40%). 18,19 A confluence of factors may be contributing to this finding; it has long been known that influenza vaccines are less immunogenic in the elderly, 20 and this group is disproportionately infected with A/H3N2 influenza subtypes, which are more genetically diverse. 17 Compounding this problem are the well-documented problems associated with egg adaptation of A/H3N2 vaccine strains, which was unchanged from the 2016 vaccine.…”

Section: Discussionmentioning

confidence: 99%

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

et al. 2019

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The Influenza Complications Alert Network (FluCAN) is a sentinel-hospital-based surveillance program that operates at sites in all jurisdictions in Australia. This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2017 influenza season. In this observational surveillance system, cases were defined as patients admitted to any of the 17 sentinel hospitals with influenza confirmed by nucleic acid detection. Data are also collected on a frequency-matched control group of influenza-negative patients admitted with acute respiratory infection. During the period 3 April to 31 October 2017 (the 2017 influenza season), 4,359 patients were admitted with confirmed influenza to one of 17 FluCAN sentinel hospitals. Of these, 52% were elderly (≥65 years), 14% were children (<16 years), 6.5% were Aboriginal and Torres Strait Islander peoples, 1.6% were pregnant and 78% had chronic comorbidities. A significant proportion were due to influenza B (31%). Estimated vaccine coverage was 72% in the elderly (≥65 years), 50% in non-elderly adults with medical comorbidities and 24% in children (<16 years) with medical comorbidities. The estimated vaccine effectiveness (VE) in the target population was 23% (95% CI: 7%, 36%). There were a large number of hospital admissions detected with confirmed influenza in this national observational surveillance system in 2017, with case numbers more than twice that reported in 2016.

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Section: Discussionmentioning

confidence: 99%

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

et al. 2019

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“…The diphtheria-tetanus-pertussis and influenza vaccines are extremely important for not only the new-born but also the mother herself [11]. …”

Section: Discussionmentioning

confidence: 99%

Impact assessment of an educational course on vaccinations in a population of medical students

Bechini

Moscadelli

Sartor

et al. 2019

Journal of Preventive Medicine and Hygiene

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“…Providing robust evidence of influenza vaccine effectiveness (IVE) in preventing severe influenza illness is important to inform current vaccination strategies. While there have been published reports of meta-analyses of studies reporting IVE against medically attended influenza 25,26 or against hospitalized outcomes in high risk groups, 27 there is a gap regarding meta-analyses of IVE focusing on severe outcomes associated with influenza viruses among adults. To provide precise estimates of IVE against laboratory-confirmed influenza-associated hospitalizations, we reviewed published results and summarized IVE estimates by adult age groups (18–64 years, ≥ 65 years of age), influenza subtype/lineage and influenza season.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of influenza vaccines in preventing severe influenza illness among adults: A systematic review and meta-analysis of test-negative design case-control studies

Rondy

Omeiri

Thompson

et al. 2017

Journal of Infection

177

111

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Summary Objectives Summary evidence of influenza vaccine effectiveness (IVE) against hospitalized influenza is lacking. We conducted a meta-analysis of studies reporting IVE against laboratory-confirmed hospitalized influenza among adults. Methods We searched Pubmed (January 2009 to November 2016) for studies that used test-negative design (TND) to enrol patients hospitalized with influenza-associated conditions. Two independent authors selected relevant articles. We calculated pooled IVE against any and (sub)type specific influenza among all adults, and stratified by age group (18–64 and 65 years and above) using random-effects models. Results We identified 3411 publications and 30 met our inclusion criteria. Between 2010–11 and 2014–15, the pooled seasonal IVE was 41% (95%CI:34;48) for any influenza (51% (95%CI:44;58) among people aged 18–64y and 37% (95%CI:30;44) among ≥65 years). IVE was 48% (95%CI:37;59), 37% (95%CI:24;50) and 38% (95%CI:23;53) against influenza A(H1N1)pdm09, A(H3N2) and B, respectively. Among persons aged ≥65 year, IVE against A(H3N2) was 43% (95%CI:33;53) in seasons when circulating and vaccine strains were antigenically similar and 14% (95%CI: −3;30) when A(H3N2) variant viruses predominated. Conclusions Influenza vaccines provided moderate protection against influenza-associated hospitalizations among adults. They seemed to provide low protection among elderly in seasons where vaccine and circulating A(H3N2) strains were antigenically variant.

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Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies

Abstract: 40Vaccination represents the most effective intervention to prevent infection, hospitalization and 41 mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine

Cited by 72 publications

References 78 publications

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

Impact assessment of an educational course on vaccinations in a population of medical students

Effectiveness of influenza vaccines in preventing severe influenza illness among adults: A systematic review and meta-analysis of test-negative design case-control studies

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