Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children

Lum, Lucy Chai See; Borja-Tabora, Charissa; Breiman, Robert F.; Vesikari, Timo; Sablan, Benjamin; Chay, Oh Moh; Tantracheewathorn, Taweewong; Schmitt, H. J.; Lau, Yu Lung; Bowonkiratikachorn, Piyaporn; Tam, John S.; Lee, Bee Wah; Tan, Kah Kee; Pejcz, Jerzy; Cha, Sung-Ho; Gutierrez-Brito, Maricruz; Kaltenis, Petras; Vertruyen, André; Czajka, Hanna; Bojarskas, Jurgis; Brooks, W. Abdullah; Cheng, Sheau Mei; Rappaport, Ruth; Baker, Sherryl; Gruber, William C.; Forrest, Bruce D.

doi:10.1016/j.vaccine.2009.11.054

Cited by 61 publications

(39 citation statements)

References 27 publications

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“…Seasonal influenza vaccination provided 20–77% in children depending on antigenic match, against laboratory‐confirmed influenza (Table 2). 18, 47, 48, 49, 50, 51, 52, 53, 54, 55 Vaccinating school children provided 23·3% (66·3–74·9) protection against influenza and indirect protection of 61% (5·8–84·7) for household contacts 56. Vaccinating pregnant women prevented laboratory‐confirmed influenza in both mothers (50%) and their infants up to 6 months of age (49–63%) 57, 58.…”

Section: Resultsmentioning

confidence: 99%

Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics – a systematic literature review

Hirve

Lambach

Paget

et al. 2016

Influenza Resp Viruses

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AimThe evidence needed for tropical countries to take informed decisions on influenza vaccination is scarce. This article reviews policy, availability, use and effectiveness of seasonal influenza vaccine in tropical and subtropical countries.MethodGlobal health databases were searched in three thematic areas – policy, availability and protective benefits in the context of human seasonal influenza vaccine in the tropics and subtropics. We excluded studies on monovalent pandemic influenza vaccine, vaccine safety, immunogenicity and uptake, and disease burden.ResultsSeventy‐four countries in the tropics and subtropics representing 60% of the world's population did not have a national vaccination policy against seasonal influenza. Thirty‐eight countries used the Northern Hemisphere and 21 countries the Southern Hemisphere formulation. Forty‐six countries targeted children and 57 targeted the elderly; though, the age cut‐offs varied. Influenza vaccine supply increased twofold in recent years. However, coverage remained lower than five per 1000 population. Vaccine protection against laboratory‐confirmed influenza in the tropics ranged from 0% to 42% in the elderly, 20–77% in children and 50–59% in healthy adults. Vaccinating pregnant women against seasonal influenza prevented laboratory‐confirmed influenza in both mothers (50%) and their infants <6 months (49–63%).ConclusionGuidelines on vaccine composition, priority risk groups and vaccine availability varied widely. The evidence on vaccine protection was scarce. Countries in the tropics and subtropics need to strengthen and expand their evidence‐base required for making informed decisions on influenza vaccine introduction and expansion, and how much benefit to expect.

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Section: Resultsmentioning

confidence: 99%

Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics – a systematic literature review

Hirve

Lambach

Paget

et al. 2016

Influenza Resp Viruses

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show abstract

“…In addition, apart from the route of administration that can influence the quality of the immune response (46), we further demonstrate that the ability of LAIVs to induce local immunity in the lower respiratory tract is determined by the ability of the vaccine virus to replicate in the lungs. Although when incorporated into a trivalent formulation the A/Panama/2007/99 (H3N2) vaccine strain provided 64% to 90% protection in young children against antigenically similar A/H3N2 strains compared to placebo in three randomized controlled studies (20,31,45), Block and colleagues found that a higher proportion of recipients of seasonal trivalent LAIV shed the A/New Caledonia/20/99 (H1N1) vaccine virus than recipients of the A/Panama/2007/99 (H3N2) vaccine virus in a clinical trial and that the H1N1 LAIV was more immunogenic than the H3N2 strain, especially in young children 5 to 8 years of age (5). Consistent with these data, the Panama99 (H3N2) ca vaccine failed to replicate efficiently in the respiratory tract of mice, and this led to a significantly reduced magnitude of primary and memory CD8…”

Section: Discussionmentioning

confidence: 99%

The Magnitude of Local Immunity in the Lungs of Mice Induced by Live Attenuated Influenza Vaccines Is Determined by Local Viral Replication and Induction of Cytokines

Lau

Santos

Torres-Vélez

et al. 2011

J Virol

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“…Recent studies have suggested that multiple concurrent vaccinations do not influence the efficacy of protection against each antigen, nor the susceptibility to other infections. [14][15][16] Ultimately, the role of vaccination on FVIII immunogenicity or tolerance remains unclear and is the subject of this report.…”

Section: Introductionmentioning

confidence: 98%

Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A

Lai

Moorehead

Sponagle

et al. 2016

Blood

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Key Points• Vaccination against influenza, with and without the adjuvant MF59, decreases the risk of inhibitor development in HA mice.• Decreased FVIII immunogenicity may be attributed to antigenic competition via T-cell chemotaxis toward the site of vaccination.Inflammatory signals such as pathogen-and danger-associated molecular patterns have been hypothesized as risk factors for the initiation of the anti-factor VIII (FVIII) immune response seen in 25% to 30% of patients with severe hemophilia A (HA). In these young patients, vaccines may be coincidentally administered in close proximity with initial exposure to FVIII, thereby providing a source of such stimuli. Here, we investigated the effects of 3 vaccines commonly used in pediatric patients on FVIII immunogenicity in a humanized HA murine model with variable tolerance to recombinant human FVIII (rhFVIII). Mice vaccinated intramuscularly against the influenza vaccine prior to multiple infusions of rhFVIII exhibited a decreased incidence of rhFVIII-specific neutralizing and nonneutralizing antibodies. Similar findings were observed with the addition of an adjuvant. Upon exposure to media from influenza-or FVIII-stimulated lymph node or splenic lymphocytes, naïve CD4 1 lymphocytes preferentially migrated toward media from influenzastimulated cells, indicating that antigen competition, by means of lymphocyte recruitment to the immunization site, is a potential mechanism for the observed decrease in FVIII immunogenicity. We also observed no differences in incidence or titer of rhFVIII-specific antibodies and inhibitors in mice exposed to the live-attenuated measles-mumps-rubella vaccine regardless of route of administration. Together, our results suggest that concomitant FVIII exposure and vaccination against influenza does not increase the risk of inhibitor formation and may in fact decrease anti-FVIII immune responses. (Blood. 2016;127(26):3439-3449)

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Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children

Cited by 61 publications

References 27 publications

Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics – a systematic literature review

Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics – a systematic literature review

The Magnitude of Local Immunity in the Lungs of Mice Induced by Live Attenuated Influenza Vaccines Is Determined by Local Viral Replication and Induction of Cytokines

Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A

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