Influenza Vaccine and Egg Allergy: Nearing the End of an Evidence-Based Journey

Kelso, John M.

doi:10.1016/j.jaip.2014.08.011

Cited by 13 publications

(20 citation statements)

References 6 publications

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“… Hymenoptera venom-induced anaphylaxis [ 135 – 139 ] In 100 adults who completed venom immunotherapy and had live sting challenges to prove efficacy, post-challenge scores on the Vespid Allergy Quality of Life Questionnaire improved significantly, independent of age, sex, or severity of the initial anaphylaxis episode [ 138 ]. Drug/iatrogenic agent-induced anaphylaxis [ 140 – 148 ] In a retrospective study of patients with a history of hypersensitivity reactions during anesthesia, comprehensive evaluation, including skin tests and measurement of basal tryptase levels, followed by development of a management plan, minimized risk of subsequent reactions even when a specific trigger such as an antibiotic, neuromuscular blocker, or latex was not identified [ 145 ]. Idiopathic anaphylaxis [ 149 , 150 ] In 20 % of 110 patients with idiopathic anaphylaxis (no identifiable trigger by history, skin tests, or allergen-specific IgE levels), the etiology of the episode was identified by using the ImmunoCAP ISAC 103 allergen array in addition to the ImmunoCAP 250 platform.…”

Section: Introductionmentioning

confidence: 99%

“…Influenza vaccine should not be withheld from egg-sensitized patients, even those with a history of egg-induced anaphylaxis [ 148 ]. The egg content of 2015 influenza vaccines is below the threshold needed to trigger reactions in egg-sensitized people.…”

Section: Introductionmentioning

confidence: 99%

“…Injected and intranasal influenza vaccines have been studied in 4315 patients with egg allergy, including 656 patients with a history of anaphylaxis to ingested egg. The rare patients with a history of urticaria or anaphylaxis after immunization with influenza vaccine need an allergy/immunology evaluation that includes skin tests to the vaccine itself [ 148 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines

Simons

Ebisawa

Sánchez‐Borges

et al. 2015

World Allergy Organization Journal

461

344

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The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence supporting recommendations in the Guidelines, new information based on anaphylaxis publications from January 2014 through mid- 2015 is summarized. Advances in epidemiology, diagnosis, and management in healthcare and community settings are highlighted. Additionally, new information about patient factors that increase the risk of severe and/or fatal anaphylaxis and patient co-factors that amplify anaphylactic episodes is presented and new information about anaphylaxis triggers and confirmation of triggers to facilitate specific trigger avoidance and immunomodulation is reviewed. The update includes tables summarizing important advances in anaphylaxis research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines

Simons

Ebisawa

Sánchez‐Borges

et al. 2015

World Allergy Organization Journal

461

344

View full text Add to dashboard Cite

show abstract

“…There have been concerns about the safety of the influenza drugs with respect to people with allergies [ 35 ] and pregnant women [ 36 - 39 ], which negatively affect the uptake of drugs.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Seasonal Influenza Surveillance: Topic Analysis of Widely Used Medicinal Drugs Using Twitter Data

Kagashe¹,

Yan²,

Suheryani³

2017

J Med Internet Res

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BackgroundUptake of medicinal drugs (preventive or treatment) is among the approaches used to control disease outbreaks, and therefore, it is of vital importance to be aware of the counts or frequencies of most commonly used drugs and trending topics about these drugs from consumers for successful implementation of control measures. Traditional survey methods would have accomplished this study, but they are too costly in terms of resources needed, and they are subject to social desirability bias for topics discovery. Hence, there is a need to use alternative efficient means such as Twitter data and machine learning (ML) techniques.ObjectiveUsing Twitter data, the aim of the study was to (1) provide a methodological extension for efficiently extracting widely consumed drugs during seasonal influenza and (2) extract topics from the tweets of these drugs and to infer how the insights provided by these topics can enhance seasonal influenza surveillance.MethodsFrom tweets collected during the 2012-13 flu season, we first identified tweets with mentions of drugs and then constructed an ML classifier using dependency words as features. The classifier was used to extract tweets that evidenced consumption of drugs, out of which we identified the mostly consumed drugs. Finally, we extracted trending topics from each of these widely used drugs’ tweets using latent Dirichlet allocation (LDA).ResultsOur proposed classifier obtained an F1 score of 0.82, which significantly outperformed the two benchmark classifiers (ie, P<.001 with the lexicon-based and P=.048 with the 1-gram term frequency [TF]). The classifier extracted 40,428 tweets that evidenced consumption of drugs out of 50,828 tweets with mentions of drugs. The most widely consumed drugs were influenza virus vaccines that had around 76.95% (31,111/40,428) share of the total; other notable drugs were Theraflu, DayQuil, NyQuil, vitamins, acetaminophen, and oseltamivir. The topics of each of these drugs exhibited common themes or experiences from people who have consumed these drugs. Among these were the enabling and deterrent factors to influenza drugs uptake, which are keys to mitigating the severity of seasonal influenza outbreaks.ConclusionsThe study results showed the feasibility of using tweets of widely consumed drugs to enhance seasonal influenza surveillance in lieu of the traditional or conventional surveillance approaches. Public health officials and other stakeholders can benefit from the findings of this study, especially in enhancing strategies for mitigating the severity of seasonal influenza outbreaks. The proposed methods can be extended to the outbreaks of other diseases.

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“…Unfortunately, they are not approved for children aged <18 years [ 17 ]. A recent editorial in the Journal of Allergy and Clinical Immunology: in Practice proposes that "no longer seeking out a particular brand of influenza vaccine with a particularly low amount egg protein is necessary" [ 43 ].…”

Section: Global Recommendations For Influenza Vaccination In Childrenmentioning

confidence: 99%

Safety of influenza vaccination in children with allergic diseases

Yang

2015

Clin Exp Vaccine Res

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Global guidelines strongly recommend annual influenza vaccination in people age 6 months and older, particularly in asthmatic children. There is no doubt about the benefit of influenza vaccination in asthmatic children. However, some of the vaccine's components may elicit an IgE mediated hypersensitivity or disease exacerbation, including life-threatening events, in children with allergic diseases. As a result, concerns regarding the safety of the vaccine still continue today. The influenza vaccine is grown on hens' eggs and contains a trace of egg protein. Consequently, it can provoke an allergic reaction or anaphylaxis in children with an egg allergy or exacerbation in those with asthma. Therefore, we need to know the risks and benefits of the influenza vaccine and the best strategy for safe vaccination. Although most guidelines have consistently reported the safety of influenza vaccination in children with allergic disease, and have recommended annual administration, safety concerns impede guideline-based performance in practice. The safety and efficacy of influenza vaccination for allergic children are summarized in the present review.

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Influenza Vaccine and Egg Allergy: Nearing the End of an Evidence-Based Journey

Cited by 13 publications

References 6 publications

2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines

2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines

Enhancing Seasonal Influenza Surveillance: Topic Analysis of Widely Used Medicinal Drugs Using Twitter Data

Safety of influenza vaccination in children with allergic diseases

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