Influenza vaccination coverage of population and the factors influencing influenza vaccination in mainland China: A meta-analysis

Wang, Qiang; Yue, Na; Zheng, Mengyun; Wang, Donglei; Duan, Chunxiao; Yu, Xiaoge; Zhang, Xuefeng; Bao, Changjun; Jin, Hui

doi:10.1016/j.vaccine.2018.10.045

Cited by 160 publications

(142 citation statements)

References 14 publications

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“…Further, we found that there were differences in the perception of the influenza vaccination and in recommending it between the two groups. Healthcare workers in the vaccinated group were more likely to recommend the influenza vaccination to their patients, as indicated in previous studies [13,16]. Therefore, we recommend improving the awareness and coverage rate of influenza vaccinations in HCWs by developing clinical guidelines and expert consensus.…”

Section: Discussionmentioning

confidence: 64%

“…An Internet survey of 2000 healthcare workers in the United States showed that the influenza vaccination coverage was 78% in the 2017-2018 season and up to 95% among those working in settings where vaccination was required by employers [12]. In China, according to the results of a 2018 systematic review, the highest vaccination coverage rate among healthcare workers in five epidemic seasons since 2010 was no more than 15% [13]. A few small-scale surveys in some cities, such as Ningbo [14], Qingdao [15], and Xining [16], have shown that the vaccination coverage ranged from 5.4% to 12.4% during the recent flu season.…”

Section: Introductionmentioning

confidence: 99%

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An Exploratory Study of Influenza Vaccination Coverage in Healthcare Workers in a Western Chinese City, 2018–2019: Improving Target Population Coverage Based on Policy Interventions

Xu¹,

Zhao²,

Peng

et al. 2020

Vaccines

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Objectives: To evaluate a policy-based intervention to increase seasonal-influenza-vaccination coverage in healthcare workers in Xining, a city in Western China. Methods: From October 2018 to March 2019, we implemented a free vaccination policy in healthcare workers in Xining. A face-to-face interview with the head of the infection control department and an online survey for medical staff in four tertiary medical facilities was conducted to understand both the implementation of the free policy and influenza vaccination coverage. Possible factors for influenza vaccination among healthcare workers (physician, nurses working on the front-line, HCWs) were investigated by multivariate-logistic regression. Results: Coverage in two hospitals that implemented the free vaccination policy was 30.5% and 25.9%, respectively, which was statistically different to hospitals that did not implement the free policy (7.2% and 8.7%, respectively) (χ2 = 332.56, p < 0.0001). Among vaccinated healthcare workers, 65.5% and 48.6% reported their main reasons for vaccination were a convenient vaccination service and awareness of the free vaccination policy. The reasons for not being vaccinated among the 3389 unvaccinated healthcare workers included: the inconvenient vaccination service (33.8%), believing vaccination was unnecessary (29.7%), concerns about adverse reactions to the vaccine (28.8%), and having to pay for the vaccine (25.6%). Conclusions: Implementing the free vaccination policy, combined with improving the accessibility of the vaccination service, increased seasonal-influenza vaccination-coverage in healthcare workers in Xining.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

An Exploratory Study of Influenza Vaccination Coverage in Healthcare Workers in a Western Chinese City, 2018–2019: Improving Target Population Coverage Based on Policy Interventions

Xu¹,

Zhao²,

Peng

et al. 2020

Vaccines

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“…a Don't take action -6 (3.9) -6 (3.9) - against seasonal influenza may provide some cross-protection against swine strains (Solorzano, Ye, & Perez, 2010). However, if a new pan- and highest level of education and income status (Maurer, 2016;Parrish et al, 2015;Quinn, Jamison, Freimuth, An, & Hancock, 2017;Wang et al, 2018). It is possible that there is an unknown confounding factor for the apparent association between uptake of vaccination against human influenza and lower levels of awareness of the zoonotic risk of SI.…”

Section: Discussionmentioning

confidence: 99%

Risk of zoonotic transmission of swine influenza at the human–pig interface in Guangdong Province, China

Edwards

Huang

et al. 2020

Zoonoses and Public Health

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A cross‐sectional survey was conducted from 2015 to 2018 to assess the risk of zoonotic influenza to humans at the human–pig interface in Guangdong Province, south China. One hundred and fifty‐three pig farmers, 21 pig traders and 16 pig trade workers were recruited using convenience sampling and surveyed at local pig farms, live pig markets and slaughterhouses, respectively. Questionnaires were administered to collect information on the biosecurity and trading practices adopted and their knowledge and beliefs about swine influenza (SI). Most (12 of 16) trade workers said they would enter piggeries to collect pigs and only six of 11 said they were always asked to go through an on‐farm disinfection procedure before entry. Only 33.7% of the interviewees believed that SI could infect humans, although pig farmers were more likely to believe this than traders and trade workers (p < .01). Several unsafe practices were reported by interviewees. ‘Having vaccination against seasonal flu’ (OR = 3.05, 95% CI: 1.19–8.93), ‘Believe that SI can cause death in pigs’ (no/yes: OR = 8.69, 95% CI: 2.71–36.57; not sure/yes: OR = 4.46, 95% CI: 1.63–14.63) and ‘Keep on working when getting mild flu symptoms’ (OR = 3.80, 95% CI: 1.38–11.46) were significantly and positively correlated to ‘lacking awareness of the zoonotic risk of SI’. ‘Lacking awareness of the zoonotic risk of SI’ (OR = 3.19, 95% CI: 1.67–6.21), ‘Keep on working when getting mild flu symptoms’ (OR = 3.59, 95% CI: 1.57–8.63) and ‘Don't know SI as a pig disease’ (OR = 3.48, 95% CI: 1.02–16.45) were significantly and positively correlated to ‘not using personal protective equipment when contacting pigs’. The findings of this study would benefit risk mitigation against potential pandemic SI threats in the human–pig interface in China.

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“…Unfortunately, measures of prevention and treatment of rhinovirus infections do not exist, albeit the viral capsid, the protease, and polymerase have been identified as valid targets of inhibitors acting against a broad spectrum of rhinovirus serotypes [6,7]. Even though influenza vaccines do exist, they are suboptimal applied [8][9][10][11]. The arsenal of drugs for treatment of influenza is limited and currently includes M2 ion channel blockers (amantadine and rimantadine), neuraminidase inhibitors (oseltamivir, zanamivir, laninamivir, and peramivir), and polymerase inhibitors (favipiravir and baloxavir) [12,13].…”

Section: Introductionmentioning

confidence: 99%

Anti-rhinovirus and anti-influenza virus activities of mucoactive secretolytic agents and plant extracts – a comparative in vitro study

Walther¹,

Schmidtke²

2020

Preprint

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Background: Rhinoviruses and influenza viruses cause the majority of acute respiratory infections (ARIs). Symptoms of ARIs are commonly treated with over-the-counter products like ambroxol, bromhexine, and N-acetylcysteine, as well as thyme and pelargonium extracts. Because the antiviral activity of these over-the-counter products has not been studied in a systematic way, the current study aimed to compare their antiviral effect against two rhinovirus and two influenza virus strains in an in vitro setting. Methods: The cytotoxicity of ambroxol, bromhexine, and N-acetylcysteine, as well as of thyme and pelargonium extracts was analyzed in Madin-Darby canine kidney (MDCK) and HeLa cells. The antiviral effect of these over-the-counter products was compared by analyzing the dose-dependent inhibition (i) of rhinovirus A2- and B14-induced cytopathic effect in HeLa cells and (ii) of influenza virus A/Hong Kong/68 (subtype H3N2)- and A/Jena/8178/09 (subtype H1N1, pandemic)-induced cytopathic effect in MDCK cells at non-cytotoxic concentrations. Results: The results revealed a good compatibility (no or only marginal cytotoxicity in MDCK and HeLa cells) of the agents that were tested. No anti-rhinoviral activity was detected at non-cytotoxic concentrations in this in vitro study setting. Ambroxol, bromhexine, and N-acetylcysteine inhibited the influenza virus-induced cytopathic effect in MDCK cells no or less than 50%. In contrast, a dose-dependent anti-influenza virus activity of thyme and pelargonium extracts was demonstrated. Conclusions: The results of our comparative in vitro study indicate differences in the antiviral efficacy of ambroxol, bromhexine, and N-acetylcysteine, as well as of thyme and pelargonium extracts and suggest that the inhibition of influenza virus replication by thyme and pelargonium extracts may contribute to the beneficial effects of these plant extracts on ARI symptoms.

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Influenza vaccination coverage of population and the factors influencing influenza vaccination in mainland China: A meta-analysis

Cited by 160 publications

References 14 publications

An Exploratory Study of Influenza Vaccination Coverage in Healthcare Workers in a Western Chinese City, 2018–2019: Improving Target Population Coverage Based on Policy Interventions

An Exploratory Study of Influenza Vaccination Coverage in Healthcare Workers in a Western Chinese City, 2018–2019: Improving Target Population Coverage Based on Policy Interventions

Risk of zoonotic transmission of swine influenza at the human–pig interface in Guangdong Province, China

Anti-rhinovirus and anti-influenza virus activities of mucoactive secretolytic agents and plant extracts – a comparative in vitro study

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