Influenza vaccination coverage in a population-based cohort of Australian-born Aboriginal and non-Indigenous older adults

Dyda, Amalie; Karki, Surendra; Kong, Marlene; Gidding, Heather; Kaldor, John; McIntyre, Peter; Banks, Emily; MacIntyre, C. Raina; Liu, Bette

doi:10.33321/cdi.2019.43.30

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…Information about vaccination status of the participants was unavailable. Evidence [39], suggests that in uenza vaccination reduces cardiovascular events and mortality and it is possible that vaccination may have impacted mortality in this study as annual in uenza vaccination coverage in adults in Australia is 54% [40].…”

Section: Discussionmentioning

confidence: 84%

Clinical characteristics and outcomes of Influenza A and B virus infection in adult Australian hospitalised patients

Sharma

Horwood

Hakendorf

et al. 2020

Preprint

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Background Influenza B is often perceived as a less severe strain of influenza. The epidemiology and clinical outcomes of influenza B have been less thoroughly investigated in hospitalised patients. The aim of this study was to describe clinical differences and outcomes between influenza A and B admitted over period of four years. Methods We retrospectively collected data of all laboratory confirmed influenza patients ³18 years at two tertiary hospitals in South Australia. Patients were confirmed as influenza positive if they had a positive polymerase-chain-reaction (PCR) test of a respiratory specimen. Complications during hospitalisation along with inpatient mortality were compared between influenza A and B. In addition, 30 day mortality and readmissions were compared. Logistic regression model compared outcomes after adjustment for age, Charlson index, sex and creatinine levels. Results Between January 2016-March 2020, 1846 patients, mean age 66.5 years, were hospitalised for influenza. Of whom, 1630 (88.3%) had influenza A and 216 (11.7%) influenza B. Influenza B patients were significantly younger than influenza A. Influenza A patients were more likely be smokers with a history of chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD) than influenza B. Complications, including pneumonia and acute coronary syndrome (ACS) were similar between two groups, however, septic shock was more common in patients with influenza B. Adjusted analyses showed similar median length of hospital stay (LOS), in hospital mortality, 30-day mortality and readmissions between the two groups. Conclusions Influenza B is less prevalent and occurs mostly in younger hospitalised patients than influenza A. Both strains contribute equally to hospitalisation burden and complications. Trial registration Australia and New Zealand Clinical Trial Registry (ANZCR) no ACTRN12618000451202 date of registration 28/03/2018

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Section: Discussionmentioning

confidence: 84%

Clinical characteristics and outcomes of Influenza A and B virus infection in adult Australian hospitalised patients

Sharma

Horwood

Hakendorf

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Information about vaccination status of the participants was unavailable. Evidence [38], suggests that influenza vaccination reduces cardiovascular events and mortality and it is possible that vaccination may have impacted mortality in this study as annual influenza vaccination coverage in adults in Australia is 54% [39].…”

Section: Discussionmentioning

confidence: 84%

Clinical characteristics and outcomes of influenza A and B virus infection in adult Australian hospitalised patients

et al. 2020

View full text Add to dashboard Cite

Background Influenza B is often perceived as a less severe strain of influenza. The epidemiology and clinical outcomes of influenza B have been less thoroughly investigated in hospitalised patients. The aims of this study were to describe clinical differences and outcomes between influenza A and B patients admitted over a period of 4 years. Methods We retrospectively collected data of all laboratory confirmed influenza patients ≥18 years at two tertiary hospitals in South Australia. Patients were confirmed as influenza positive if they had a positive polymerase-chain-reaction (PCR) test of a respiratory specimen. Complications during hospitalisation along with inpatient mortality were compared between influenza A and B. In addition, 30 day mortality and readmissions were compared. Logistic regression model compared outcomes after adjustment for age, Charlson index, sex and creatinine levels. Results Between January 2016–March 2020, 1846 patients, mean age 66.5 years, were hospitalised for influenza. Of whom, 1630 (88.3%) had influenza A and 216 (11.7%) influenza B. Influenza B patients were significantly younger than influenza A. Influenza A patients were more likely be smokers with a history of chronic obstructive pulmonary disease (COPD) and ischaemic heart disease (IHD) than influenza B. Complications, including pneumonia and acute coronary syndrome (ACS) were similar between two groups, however, septic shock was more common in patients with influenza B. Adjusted analyses showed similar median length of hospital stay (LOS), in hospital mortality, 30-day mortality and readmissions between the two groups. Conclusions Influenza B is less prevalent and occurs mostly in younger hospitalised patients than influenza A. Both strains contribute equally to hospitalisation burden and complications. Trial registration Australia and New Zealand Clinical Trial Registry (ANZCR) no ACTRN12618000451202 date of registration 28/03/2018

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“…Use of clinical and public health interventions may vary by both First Nations status as well as by location. This is evident with higher uptake of seasonal influenza immunisation amongst First Nations populations compared to non-Indigenous populations, although coverage is still sub-optimal (41,42). No study reported on use of non-pharmaceutical interventions, such as isolation.…”

Section: Discussionmentioning

confidence: 99%

Outcomes Reported for Australian First Nation Populations for the Influenza A(H1N1) 2009 Pandemic and Lessons for Future Infectious Disease Emergencies: a Systematic Review

et al. 2020

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Aims: Enhanced data collection during infectious disease emergencies, such as the COVID-19 pandemic, must inform the clinical and public health responses appropriate for Australian First Nations populations. To inform the design of such data collection protocols, we systematically reviewed the reported outcomes for the First Nations population related to A(H1N1) 2009 pandemic influenza infection. Methods: We searched PubMed and Google using the search terms: pandemic AND Australia AND 2009 AND (Indigenous OR Aboriginal OR "Torres Strait"). Data extracted included: location; study design; data source(s), number of study participants and the number and percentage that were First Nations; completeness of First Nations status; and reported outcomes (stratified by First Nations status). Each study was also reviewed for documentation of engagement or consultation with First Nation individuals, communities or health services regarding the study design, data collection, analysis, interpretation and reporting. Results: Our search identified 53 citations, with 13 deemed eligible for inclusion. Most studies were case-series (n=6) and used primary data (n=8) and/or secondary data (n=10). The number of First Nations participants ranged from 13 to 3,966. The proportion of First Nations participants per study varied from 1.8% to 100%. Completeness of reporting First Nations status ranged from 62% to 100%. Reported outcomes stratified by First Nations status included notification rate (n=3), comorbidities/risk factors (n=4), severity of disease (hospital admission (n=8), intensive care unit admission (n=8), death (n=5)) and interventions (anti-viral use (n=2) and vaccination (n=4)). There were no studies that described engagement/consultation with First Nations individuals, communities or health services regarding any aspect of the study process. Conclusion: Studies identified in this review mostly used secondary data and reported on outcomes relating to severity, and comorbidities and other risk factors. Studies specifically designed for First Nations populations are required to fully understand the contributing factors for the frequency and severity of disease in an infectious disease emergency and inform appropriate responses. First Nations communities and health services need to be adequately engaged and participate in the design, implementation, analysis and reporting of such enhanced data collection studies.

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Influenza vaccination coverage in a population-based cohort of Australian-born Aboriginal and non-Indigenous older adults

Cited by 7 publications

References 21 publications

Clinical characteristics and outcomes of Influenza A and B virus infection in adult Australian hospitalised patients

Clinical characteristics and outcomes of Influenza A and B virus infection in adult Australian hospitalised patients

Clinical characteristics and outcomes of influenza A and B virus infection in adult Australian hospitalised patients

Outcomes Reported for Australian First Nation Populations for the Influenza A(H1N1) 2009 Pandemic and Lessons for Future Infectious Disease Emergencies: a Systematic Review

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